DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Syt14 and syt14

DIOPT Version :9

Sequence 1:	NP_001262249.1	Gene:	Syt14 / 40544	FlyBaseID:	FBgn0261086	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	XP_012817119.1	Gene:	syt14 / 100491102	XenbaseID:	XB-GENE-985615	Length:	793	Species:	Xenopus tropicalis

Alignment Length:	529	Identity:	180/529 - (34%)
Similarity:	276/529 - (52%)	Gaps:	71/529 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 RRYENTSSDSEEDILRR-----LRWHQQHQLGEKPGGYGLGISQA-NPLTAQSFNYHQAGASAD- 130
            |.:..:||:||:::|.:     .|.|......:|...|.....|. :||:|: ::.:.:..|||
Frog   321 RDFHGSSSESEDEVLGKYQEAMTRQHTNRNTTDKQQNYTWETRQKYSPLSAE-YDGYSSEVSADE 384

  Fly   131 ---LQRV--TVSRDPLAIAERGKVGIPSSHSECSSNDSMEVSVDSHTGVLTGLSKATTTVPHPAT 190
               :||:  |...|.|.         |..:.:.|.:..:..:..........||:.:.:   |..
Frog   385 ANCIQRMRRTPPLDELQ---------PPPYQDDSGSPRLSCTPSEIGDSKCELSRCSNS---PRY 437

  Fly   191 AFRNPCGEHRAKTQALRYQHRVNVAAPPKLDKERDNVLVVPMVNAYSINNNNNSITTSNNHPSSN 255
            :|.....|.....:|..:|::         ..|.|    ||
Frog   438 SFTKCPSEGSMGHEAESFQNK---------GYEED----VP------------------------ 465

  Fly   256 NNDDEPLFDTSDLRSIKSDDLLVGVDQKEPAVQRGPIELELSLLYDAPMRKMTVHVMQAKNLPPL 320
             :|...:....|:.:..|...|......||..:.|  .|:::..||:..:|:.|.|....:||..
Frog   466 -SDSTAVLSPEDMSARGSSSQLPKSFDPEPVAKYG--TLDVTFDYDSQEQKLLVTVTAVTDLPTH 527

  Fly   321 G-SGQTTHTQVRMLMLPSKKQKLKTKIRSGENPQYMESFLLHRVNPEDVNNMGLRVRLYGCERLR 384
            . :|.....||.:::||.|||:.||.::.|..|.:.|:|..:.:..|.:.|..:|.|||...|::
Frog   528 NRTGNNNSWQVHLVLLPVKKQRAKTAVQRGPCPAFTETFKFNHIESEMIANYAVRFRLYLVRRMK 592

  Fly   385 KERLIGEAYVSFATVDLELETNLWLP--LEPRNTSSGLGSTSDLLSLARSESAGSTSSMQHGGVS 447
            |||::||..  |....|.|:..|.||  |||..:.||..|...:..::.:||..|..|:.||.|.
Frog   593 KERMVGEKI--FYLTKLNLQGKLSLPVVLEPAYSLSGCDSQMSMSEMSCTESTSSCQSLVHGSVP 655

  Fly   448 ELLLGLSYNGVTGRLSVEIIKGSQFRSLSLNKAPDTYVKMVMVSSIGQEISRAKTSIRRGQPNPL 512
            |:|:||.||..|||||.|:||||.|::||.|:.|:||||:.:::|:|||:|:.||||||||.|||
Frog   656 EILIGLLYNATTGRLSAEVIKGSHFKNLSANRPPNTYVKLTLMNSMGQEMSKCKTSIRRGQSNPL 720

  Fly   513 FKETFAFQVALFQLNDVTLMISVYAKRHMKKNEMVGWFSLGLNSSGSEEVAHWADVCEMPKGEML 577
            :||||.||||||||::|||::|||.||.||:.|::||.||||||||.|::.||.::.| .||:.:
Frog   721 YKETFIFQVALFQLSEVTLILSVYNKRSMKRKELIGWISLGLNSSGDEQLNHWTEMKE-SKGQQV 784

  Fly   578 ARWHVLVDS 586
            .|||.|::|
Frog   785 CRWHTLLES 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syt14	NP_001262249.1	C2A_Synaptotagmin-14_16	291..413	CDD:176035	41/124 (33%)
Syt14	NP_001262249.1	C2B_Synaptotagmin-14_16	446..584	CDD:176053	84/137 (61%)
syt14	XP_012817119.1	C2A_Synaptotagmin-14_16	497..621	CDD:176035	42/127 (33%)
syt14	XP_012817119.1	C2B_Synaptotagmin-14_16	654..791	CDD:176053	84/137 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	155	1.000	Domainoid score	I4203
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D339484at33208
OrthoFinder	1	1.000	-	-		FOG0002721
OrthoInspector	1	1.000	-	-		oto102372
Panther	1	1.100	-	-	O	PTHR46129
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2510
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.020