DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Suv3 and SUV3

DIOPT Version :9

Sequence 1:	NP_001303458.1	Gene:	Suv3 / 40543	FlyBaseID:	FBgn0037232	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_015296.1	Gene:	SUV3 / 856078	SGDID:	S000005950	Length:	737	Species:	Saccharomyces cerevisiae

Alignment Length:	734	Identity:	230/734 - (31%)
Similarity:	370/734 - (50%)	Gaps:	124/734 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LYLRPSF---SIDLSLRRLH--RAAFLFSRKKPETNLSTL-----------FKPVQVHAYVDSED 66
            :||:.|.   ::|.:::.::  :.:.|.:::.|..||:.|           ...:|...||.|.
Yeast    75 VYLQDSSFKDNLDKAMQFIYNDKLSSLDAKQVPIKNLAWLKLRDYIYQQLKDPKLQAKTYVPSV- 138

  Fly    67 VGSELSGKLEKAELLKIL---NKFTQ---RREIK-SLCNE-NGLDDYLQ--QQAFGSFRRFCIEA 121
              ||:........|:.:|   ||.:.   :..:| ||.|. ..||.::.  ||.|.    ...|.
Yeast   139 --SEIIHPSSPGNLISLLINCNKISNLVWKSVLKYSLSNNITTLDKFIHVLQQTFD----HVYEQ 197

  Fly   122 ENLPVDLHITFSDITQGAGHIDDIFPYFLRHAKTVFPHLDCMDDLKKISDLRQPANWYSNARAIT 186
            |.||:   :|.:|.|.||.::                            |:..||.|:..||.|.
Yeast   198 EILPM---MTNTDDTDGAHNV----------------------------DITNPAEWFPEARKIR 231

  Fly   187 RKIVFHAGPTNSGKTYHAMERYLSAKTGVYCGPLKLLATEVYNKANERGTPCDLVTGEE--RKF- 248
            |.|:.|.|||||||||.|:::..|...|.|.|||:|||.|||::.:.....|:|:||||  |..
Yeast   232 RHIIMHIGPTNSGKTYRALQKLKSVDRGYYAGPLRLLAREVYDRFHAEKIRCNLLTGEEVIRDLD 296

  Fly   249 --GISESLPANHVACTVEMTSVNTPYEVAVIDEIQQIRDPQRGWAWTRAFLGLIADEVHVCGEPG 311
              |.|..|.:.    ||||..:|..::|.|:||||.:.|..||||||.|.||:::.|||:|||..
Yeast   297 DRGNSAGLTSG----TVEMVPINQKFDVVVLDEIQMMSDGDRGWAWTNALLGVVSKEVHLCGEKS 357

  Fly   312 ALDLLQKICETTGETVEVRLYDRLTELTVENTAL-GSLDNIVPGDCIVCFSKHDIYTVSREIEA- 374
            .|.|::.|.:.||:.:.:..|:||.:|:||...: ..:..:..|||:|.|||..|..:..:||.
Yeast   358 VLPLVKSIVKMTGDKLTINEYERLGKLSVEEKPIKDGIKGLRKGDCVVAFSKKKILDLKLKIEKD 422

  Fly   375 RGKEVAVIYGGLPPGTKLAQAAKFNDPANSCKVMVATDAIGMGLNLSIRRIIFYSLIKPSMNERG 439
            ...:||||||.|||.|::.|||.||:  ....:|||:|||||||||||.|::|.:    :|...|
Yeast   423 TNLKVAVIYGSLPPETRVQQAALFNN--GEYDIMVASDAIGMGLNLSIDRVVFTT----NMKYNG 481

  Fly   440 EREIDTISVSSALQIAGRAGRFRTQ-----WEHGYVTAFKSEDLQTLQRILARTPEPIKQAGLHP 499
            | |:..::.|...||.||||||:::     ...|::|:|:|:.|:::::.:....|.:|.|...|
Yeast   482 E-ELMEMTSSQIKQIGGRAGRFKSRSASGGVPQGFITSFESKVLKSVRKAIEAPVEYLKTAVTWP 545

  Fly   500 TADQI--ELYAYHLPSSSLSNLMD-IFVNLCTVDDSLYFMCNIEDFKFLAEMIQHVA-LPLRARY 560
            | |:|  :|.....|.:..|.|:. |...|....|:|:.:.:::....:..:.:|:. :|...:.
Yeast   546 T-DEICAQLMTQFPPGTPTSVLLQTISDELEKSSDNLFTLSDLKSKLKVIGLFEHMEDIPFFDKL 609

  Fly   561 VFCCAPINRKMPFVCSMFLK----VARQYSR---NEPITFDFIKKNCGWPFKLPKTILDLVHLEA 618
            ....||: :.||.|...|.|    :|::::|   :..:.|:.:..||     :|.....|...|:
Yeast   610 KLSNAPV-KDMPMVTKAFTKFCETIAKRHTRGLLSYRLPFNLLDYNC-----IPNESYSLEVYES 668

  Fly   619 VFDVMDLYLWLSYRFMDLFPEAAYVRDAQKELDEIIQQGVFQ-ITRLLKNTEASQD-GETSNYAI 681
            :::::.||.|||.|:.:.|.:    .::.|:|....:..:|: :.||.||..|.:. |.|..:.
Yeast   669 LYNIITLYFWLSNRYPNYFID----MESAKDLKYFCEMIIFEKLDRLKKNPYAHKPFGSTRGHL- 728

  Fly   682 RRITHVKEPRLPSLSRGRL 700
                        |.||.||
Yeast   729 ------------SSSRRRL 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Suv3	NP_001303458.1	DEXDc	193..323	CDD:238005	62/134 (46%)
		SrmB	195..507	CDD:223587	135/325 (42%)
		HELICc	<357..461	CDD:238034	49/104 (47%)
		SUV3_C	614..657	CDD:289293	10/42 (24%)
SUV3	NP_015296.1	DEXQc_Suv3	232..378	CDD:350671	67/149 (45%)
		SF2_C_suv3	382..519	CDD:350192	59/143 (41%)
		SUV3_C	666..710	CDD:403643	11/47 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344855
Domainoid	1	1.000	79	1.000	Domainoid score	I2058
eggNOG	1	0.900	-	-		E1_KOG0953
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	279	1.000	Inparanoid score	I562
Isobase	1	0.950	-	0	Normalized mean entropy	S1448
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003663
OrthoInspector	1	1.000	-	-		oto99029
orthoMCL	1	0.900	-	-		OOG6_101922
Panther	1	1.100	-	-	LDO	PTHR12131
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1417
SonicParanoid	1	1.000	-	-		X3030
TreeFam	1	0.960	-	-
	14	13.730