DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Suv3 and supv3l1

DIOPT Version :9

Sequence 1:	NP_001303458.1	Gene:	Suv3 / 40543	FlyBaseID:	FBgn0037232	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_001077033.1	Gene:	supv3l1 / 570852	ZFINID:	ZDB-GENE-030131-2838	Length:	763	Species:	Danio rerio

Alignment Length:	784	Identity:	444/784 - (56%)
Similarity:	550/784 - (70%)	Gaps:	80/784 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LHRAAFLFSRKK------PETNLST----------------------------------LFKPVQ 57
            ::|..:|.||..      ..|||||                                  ||.|:.
Zfish     3 VNRCIYLLSRSHIRYRVCASTNLSTVSTLSTTQHSTRRTFDKLSTRHSSSGSSRPLDTSLFIPLP 67

  Fly    58 VHAYVDSE-DVGSELSGKLEKAELLKILNKFTQRREIKSLCNENGLDDYLQQQAFGSFRRFCIEA 121
            |....|:| .||:||:..|:|.||||:||:|.:|:|::.|.::.|||..|..|||.|||::.:|.
Zfish    68 VKTDEDAEGSVGAELTKPLDKNELLKVLNRFYKRKEMQKLASDQGLDARLFHQAFVSFRKYVLEM 132

  Fly   122 ENLPVDLHITFSDITQGAGHIDDIFPYFLRHAKTVFPHLDCMDDLKKISDLRQPANWYSNARAIT 186
            .:|..||||..:||..||||||||||||:||||.:||.|||:|||:||||||.|||||..||||.
Zfish   133 NSLNADLHIILNDICCGAGHIDDIFPYFMRHAKQIFPMLDCIDDLRKISDLRVPANWYPEARAIQ 197

  Fly   187 RKIVFHAGPTNSGKTYHAMERYLSAKTGVYCGPLKLLATEVYNKANERGTPCDLVTGEERKFGIS 251
            ||||||||||||||||||::|||.||:|||||||||||.|:|.|:|..|.||||||||||.|...
Zfish   198 RKIVFHAGPTNSGKTYHAIKRYLEAKSGVYCGPLKLLAHEIYEKSNAAGVPCDLVTGEERIFVDP 262

  Fly   252 ESLPANHVACTVEMTSVNTPYEVAVIDEIQQIRDPQRGWAWTRAFLGLIADEVHVCGEPGALDLL 316
            |..|:.|:|.|:||.||.||||||||||||.|:||.||||||||.|||.|:|:|||||..|:|.:
Zfish   263 EGKPSGHIASTIEMCSVTTPYEVAVIDEIQMIKDPARGWAWTRALLGLCAEEIHVCGEAAAVDFI 327

  Fly   317 QKICETTGETVEVRLYDRLTELTVENTALGSLDNIVPGDCIVCFSKHDIYTVSREIEARGKEVAV 381
            .::..||||.|||..|.|||..::.|.|:.||||:.||||||||||:|||::||:||.||.|.||
Zfish   328 TELMFTTGEEVEVHNYKRLTPFSISNHAVESLDNLKPGDCIVCFSKNDIYSISRQIEIRGLECAV 392

  Fly   382 IYGGLPPGTKLAQAAKFNDPANSCKVMVATDAIGMGLNLSIRRIIFYSLIKPSMNERGEREIDTI 446
            |||.||||||||||.|||||.:.||::|||||||||||||||||||.||:|.|:||:||:|:|||
Zfish   393 IYGSLPPGTKLAQAKKFNDPDDPCKILVATDAIGMGLNLSIRRIIFNSLVKHSLNEKGEKEVDTI 457

  Fly   447 SVSSALQIAGRAGRFRTQWEHGYVTAFKSEDLQTLQRILARTPEPIKQAGLHPTADQIELYAYHL 511
            |.|.|||||||||||.:.::.|.||....:||..|:.||.:..:||..|||||||:|||::||||
Zfish   458 STSQALQIAGRAGRFSSVFKEGEVTTMHRDDLPVLKEILGKPVDPIATAGLHPTAEQIEMFAYHL 522

  Fly   512 PSSSLSNLMDIFVNLCTVDDSLYFMCNIEDFKFLAEMIQHVALPLRARYVFCCAPINRKMPFVCS 576
            |.::||||:||||:|..| |.|||:|||:||||||:||||:.|.||:|||||.||||:|.||||:
Zfish   523 PQATLSNLIDIFVSLSQV-DGLYFVCNIDDFKFLADMIQHIPLNLRSRYVFCTAPINKKQPFVCT 586

  Fly   577 MFLKVARQYSRNEPITFDFIKKNCGWPFKLPKTILDLVHLEAVFDVMDLYLWLSYRFMDLFPEAA 641
            .|||.|||:||:||:||:::.:...||...||.|.||||||||.||:||||||||||||:||::.
Zfish   587 SFLKFARQFSRDEPLTFNWVCRQVNWPLSPPKNIKDLVHLEAVHDVLDLYLWLSYRFMDMFPDSN 651

  Fly   642 YVRDAQKELDEIIQQGVFQITRLLK-------NTEASQ-----DGETS---NYAIRRITHVKE-P 690
            .:|:.||||||.||.||..||||::       :||::.     :.|||   ...:|.....|| |
Zfish   652 QIREIQKELDENIQIGVRNITRLIRAIDSQPTDTESNSSSTVPESETSQRKGRVLRSQNQRKELP 716

  Fly   691 RLPSLSRGRLTERLLAQGLLTPGMLSELRKEWDAQQLGKSNSQSNENSEPVVNSDDEDNYSGIGR 755
            |..|||     .|||..||||..:||:|:|||       :..|:.:||.||.|          |:
Zfish   717 RKSSLS-----SRLLRDGLLTKELLSQLQKEW-------AREQNEDNSIPVNN----------GK 759

  Fly   756 KTRK 759
            :.:|
Zfish   760 RKKK 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Suv3	NP_001303458.1	DEXDc	193..323	CDD:238005	88/129 (68%)
		SrmB	195..507	CDD:223587	209/311 (67%)
		HELICc	<357..461	CDD:238034	80/103 (78%)
		SUV3_C	614..657	CDD:289293	31/42 (74%)
supv3l1	NP_001077033.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..58		0/18 (0%)
		DEXDc	185..351	CDD:214692	114/165 (69%)
		DEXDc	204..311	CDD:238005	78/106 (74%)
		SrmB	<281..>495	CDD:223587	144/213 (68%)
		HELICc	<368..484	CDD:238034	85/115 (74%)
		SUV3_C	624..670	CDD:289293	33/45 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	679..721		10/41 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..763		9/37 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587193
Domainoid	1	1.000	272	1.000	Domainoid score	I1764
eggNOG	1	0.900	-	-		E1_KOG0953
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2386
Inparanoid	1	1.050	847	1.000	Inparanoid score	I422
OMA	1	1.010	-	-		QHG45841
OrthoDB	1	1.010	-	-		D1106167at2759
OrthoFinder	1	1.000	-	-		FOG0003663
OrthoInspector	1	1.000	-	-		oto38899
orthoMCL	1	0.900	-	-		OOG6_101922
Panther	1	1.100	-	-	LDO	PTHR12131
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1417
SonicParanoid	1	1.000	-	-		X3030
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800