DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MP1 and PRSS27

DIOPT Version :9

Sequence 1:	NP_001303421.1	Gene:	MP1 / 40541	FlyBaseID:	FBgn0027930	Length:	400	Species:	Drosophila melanogaster
Sequence 2:	NP_114154.1	Gene:	PRSS27 / 83886	HGNCID:	15475	Length:	290	Species:	Homo sapiens

Alignment Length:	288	Identity:	99/288 - (34%)
Similarity:	142/288 - (49%)	Gaps:	44/288 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 GTKLLPMAPNCGE-NFGDRVVGGNETTKREFPWMALIEYTKPGNVKGHHCGGSLINHRYVLTAAH 183
            |::....|..||. ...:|:|||.:|.:.|:||...|:  :.|:   |.||||||..::||||||
Human    16 GSQRAKAATACGRPRMLNRMVGGQDTQEGEWPWQVSIQ--RNGS---HFCGGSLIAEQWVLTAAH 75

  Fly   184 CVSAIPSDWELTGVRLGEWDASTNPDCTVGKNGRRDCNEPYVDYP-VEERIPHPQYPGNSRDQLN 247
            |... .|:..|..|.||.... ..|.             |:..|. |.:...:|.|.|.:...
Human    76 CFRN-TSETSLYQVLLGARQL-VQPG-------------PHAMYARVRQVESNPLYQGTASSA-- 123

  Fly   248 DIALLRLRDEVQYSDFILPVCLPTLASQHNNIF-LGRKVVVAGWGR-TETNFTSNIKL--KAELD 308
            |:||:.|...|.::::|||||||    ..:.|| .|....|.|||. :|.:.....::  |..:.
Human   124 DVALVELEAPVPFTNYILPVCLP----DPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVP 184

  Fly   309 TVPTSECNQRYAT------QRRTVTTKQMCAGGVEG-VDSCRGDSGGPLLLEDYSNGNSNYYIAG 366
            .:.|.:||..|:.      |.:|:....:|||..|| .|:|:|||||||:.   ..|.| :..||
Human   185 IIDTPKCNLLYSKDTEFGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVC---LVGQS-WLQAG 245

  Fly   367 VVSYGPTPCGLKGWPGVYTRVEAYLNWI 394
            |:|:| ..|..:..||||.||.|:.|||
Human   246 VISWG-EGCARQNRPGVYIRVTAHHNWI 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MP1	NP_001303421.1	CLIP	29..91	CDD:288855
		Tryp_SPc	137..394	CDD:214473	93/268 (35%)
		Tryp_SPc	138..397	CDD:238113	94/269 (35%)
PRSS27	NP_114154.1	Tryp_SPc	34..272	CDD:214473	93/268 (35%)
PRSS27	NP_114154.1	Tryp_SPc	36..275	CDD:238113	94/268 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810