DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MP1 and PRSS41

DIOPT Version :9

Sequence 1:	NP_001303421.1	Gene:	MP1 / 40541	FlyBaseID:	FBgn0027930	Length:	400	Species:	Drosophila melanogaster
Sequence 2:	NP_001382429.1	Gene:	PRSS41 / 360226	HGNCID:	30715	Length:	334	Species:	Homo sapiens

Alignment Length:	292	Identity:	97/292 - (33%)
Similarity:	143/292 - (48%)	Gaps:	44/292 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 PTKRSGTKLLPMAPNCG-ENFGDRVVGGNETTKREFPWMALIEYTKPGNVKGHHCGGSLINHRYV 178
            |.:....:||..|  || ......|.||.|:.:..:||.|.:...     :.|.|||||::.|:|
Human    49 PAESQEEELLSEA--CGHREIHALVAGGVESARGRWPWQASLRLR-----RRHRCGGSLLSRRWV 106

  Fly   179 LTAAHCVSA--IPSDWELTGVRLGEWDASTNPDCTVGKNGRRDCNEPYVDYPVEERIPHPQYPGN 241
            |:||||...  .||:|.   |:|||..:...|......:.|         |.|::.|.:|...|.
Human   107 LSAAHCFQKHYYPSEWT---VQLGELTSRPTPWNLRAYSSR---------YKVQDIIVNPDALGV 159

  Fly   242 SRDQLNDIALLRLRDEVQYSDFILPVCLPTLASQHNNIFLGR-KVVVAGWGRTETNFTS-----N 300
            .|   ||||||||...|.|:.:|.|:|:.  :|..|  |:.| ...|.|||....:.|.     |
Human   160 LR---NDIALLRLASSVTYNAYIQPICIE--SSTFN--FVHRPDCWVTGWGLISPSGTPLPPPYN 217

  Fly   301 IKLKAELDTVPTSECNQRY--ATQRRTVTTKQMCAGGVEG-VDSCRGDSGGPLLLEDYSNGNSNY 362
            :: :|::..:..:.||..:  .:.|..:.....|||..:| ||:|:|||||||:.:.    :..:
Human   218 LR-EAQVTILNNTRCNYLFEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDK----DGLW 277

  Fly   363 YIAGVVSYGPTPCGLKGWPGVYTRVEAYLNWI 394
            |..|:||:| ..||....|||||.:..|.:||
Human   278 YQVGIVSWG-MDCGQPNRPGVYTNISVYFHWI 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MP1	NP_001303421.1	CLIP	29..91	CDD:288855
		Tryp_SPc	137..394	CDD:214473	89/267 (33%)
		Tryp_SPc	138..397	CDD:238113	91/268 (34%)
PRSS41	NP_001382429.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910