DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl11 and ECE2

DIOPT Version :9

Sequence 1:	NP_649449.1	Gene:	Nepl11 / 40540	FlyBaseID:	FBgn0037230	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001093590.1	Gene:	ECE2 / 9718	HGNCID:	13275	Length:	811	Species:	Homo sapiens

Alignment Length:	731	Identity:	157/731 - (21%)
Similarity:	256/731 - (35%)	Gaps:	190/731 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LAVLWIAGIAYGQDD---------LLRVETELLSFSHNLEPYLDTSKQPCQDFYGYVCSH--SAN 59
            |..|...|:.|.:|.         .:||..::|.       .||....||:|||.:.|..  ..|
Human   121 LGCLVALGVQYHRDPSHSTCLTEACIRVAGKILE-------SLDRGVSPCEDFYQFSCGGWIRRN 178

  Fly    60 LSETGRQRFQS--------------LLKETDVAQLMDMELQLINFFKSCESGRGVEALKGSQ--- 107
            ....||.|:.:              ||:.|......:.|.:...|:.||.....:|.| |:|
Human   179 PLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEEL-GAQPLR 242

  Fly   108 -LYRQSGGW----PSLEPNKVNASQRTNQTQRWLGLLGYFHEVGAPYF--FETSVTMQSNKRLVV 165
             |..:.|||    |..:.|.:...:....|.|           ..|:|  :.::.:..||..::.
Human   243 DLIEKIGGWNITGPWDQDNFMEVLKAVAGTYR-----------ATPFFTVYISADSKSSNSNVIQ 296

  Fly   166 LQPDG-------------TRRNTLRKFEQRVGEVLQSFGIEQSRAHVTALEVLSLERSRRDI-VK 216
            :...|             .....|..:...:.|:....|...:.......:||.||....:| |.
Human   297 VDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVP 361

  Fly   217 ADHVEDQVQFSYGNFKRIVFGNASLIRL-------DWDGYFRKLLGGKTPQASDTIVVKQLPRLV 274
            .|...|:.:         ::...|:..|       ||..:...||.......|:.:||..:..|.
Human   362 QDQRRDEEK---------IYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQ 417

  Fly   275 EYFALLQNTSMVRLLNW-IW------TDYLMDIVDADCHQLSETYAGDLYAHVVQ---------- 322
            :...|:..|....|.|: ||      |..|....::...:|.||..|...:.|.:
Human   418 QVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDD 482

  Fly   323 -----------RVTANR--VELAQ-MYSELGKAYTDQLGGSVWIDEISRQSSRQFLGNIMHTTLN 373
                       :.|.:|  .|:|: |.||:..|:.:.||..||:||.:||::::....|......
Human   483 ALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGF 547

  Fly   374 GD-----ERLDAAYHSILLGRRSLYRNLEKLRKFQRTRRLASHSAQQVRR------YAQMFAPVN 427
            .|     :.||..|....:...|.::|:..|..|.     |...|.|:|:      ::.....||
Human   548 PDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFS-----AKVMADQLRKPPSRDQWSMTPQTVN 607

  Fly   428 A-FLGQHN--------LSTP---------LNY----LLLGEFFSRSLVAAGSSSRTQG---AWRS 467
            | :|...|        |..|         ||:    :::|...:.:....|.....:|   .|..
Human   608 AYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQ 672

  Fly   468 SDSERRFAIFQQCVGKQTNAIDLLLSLLAQRQAL--------------SAYGQWLATQAGLVERV 518
            ::|...|.....|:.:|.|...:....|..||.|              :||..|| .:.|..:::
Human   673 NESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWL-RKHGEEQQL 736

  Fly   519 DAVLAAGSSKMSLQRLFFVTSLLVDCRSELGALQQDRKRQVT--HA--------TLRNSPEFLEA 573
            .||      .::..:||||....|.|  .:...:...:..||  |:        ||.||.:||..
Human   737 PAV------GLTNHQLFFVGFAQVWC--SVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRH 793

  Fly   574 FRCRPGDVLYPQDQRC 589
            |.|..|..:.| .|.|
Human   794 FGCPVGSPMNP-GQLC 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	146/681 (21%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..64
ECE2	NP_001093590.1	M13	160..809	CDD:189000	147/685 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910