DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl11 and ECEL1

DIOPT Version :9

Sequence 1:	NP_649449.1	Gene:	Nepl11 / 40540	FlyBaseID:	FBgn0037230	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_004817.2	Gene:	ECEL1 / 9427	HGNCID:	3147	Length:	775	Species:	Homo sapiens

Alignment Length:	744	Identity:	152/744 - (20%)
Similarity:	264/744 - (35%)	Gaps:	203/744 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MISKALAVLWIAGIAYGQDDLLRVETELLSFSHN---LEPYLDTSKQPCQDFYGYVCS-----HS 57
            :::..||:.::..:|.|.........|..:|:..   |...||.|..||||||.:.|.     |:
Human    75 ILAAMLALKYLGPVAAGGGACPEGCPERKAFARAARFLAANLDASIDPCQDFYSFACGGWLRRHA 139

  Fly    58 -----------ANLSETGRQRFQSLLKETDVAQLMDMELQLINFFKSCESGRGVEALKGS---QL 108
                       |.:.|...:|.:.||...........:.::..||:||...|.:|.|...   ::
Human   140 IPDDKLTYGTIAAIGEQNEERLRRLLARPGGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEV 204

  Fly   109 YRQSGGWPSLEPNKVNASQRTNQTQRW-LGLLGY----FHEVGAPYFFETSVTMQSNKRLVV-LQ 167
            ....|||     :...|.:|.....|| |..|.|    .:...|.:....|:..:::.|.|: :.
Human   205 IEDCGGW-----DLGGAEERPGVAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRID 264

  Fly   168 PDGTR--RNTL---------------RKFEQRVGEVLQSFGIEQSRAHVTALEVLSLERSRRDIV 215
            .||..  ..||               |.|.:||..:|.:..:||.     |.|:|.:|:...:|.
Human   265 QDGLTLPERTLYLAQDEDSEKILAAYRVFMERVLSLLGADAVEQK-----AQEILQVEQQLANIT 324

  Fly   216 KADHVEDQVQFSYGNFKRIVFGNASLI----RLDW--DGYFRKLLGGKTPQASDTIVVKQLPRLV 274
            .::| :|..:.....:.::..|....|    |..|  |..|::..     ...:.:|:.....:.
Human   325 VSEH-DDLRRDVSSMYNKVTLGQLQKITPHLRWKWLLDQIFQEDF-----SEEEEVVLLATDYMQ 383

  Fly   275 EYFALLQNTSMVRLLNW-IW------TDYLMDIVDADCHQLSETYAGDLYAHVVQRV---TANR- 328
            :...|:::|....|.|: :|      :::|........|:|::...|......:.||   .|||
Human   384 QVSQLIRSTPHRVLHNYLVWRVVVVLSEHLSPPFREALHELAQEMEGSDKPQELARVCLGQANRH 448

  Fly   329 -------VELAQMYSELGKAYTDQLGGSV------------WIDEISRQSSRQFLGNIMHTT--- 371
                   :.:.:.:|...||...||...:            |:|..:|.::|..|..:|...
Human   449 FGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARAKLQYMMVMVGYP 513

  Fly   372 --LNGDERLDAAY--------------HSILLGRRSLYRNLEKLRKFQRTRRLASHSAQQVRRYA 420
              |...:.:|..|              :||   |.|:..:::|:|             |:|.:..
Human   514 DFLLKPDAVDKEYEFEVHEKTYFKNILNSI---RFSIQLSVKKIR-------------QEVDKST 562

  Fly   421 QMFAP--VNAF-------------LGQHNLSTP-----LNYLLLGEFFSRSLVA-----AGSSSR 460
            .:..|  :||:             :.|..|..|     |||..:|......|..     .|...|
Human   563 WLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDR 627

  Fly   461 TQGA--WRSSDSERRFAIFQQCV---------------GKQT---NAIDLLLSLLAQRQALSAYG 505
            :...  |.:..|..||....:|:               ||.|   |..|    :...:.|..||.
Human   628 SGNLLHWWTEASYSRFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIAD----MGGLKLAYHAYQ 688

  Fly   506 QWLATQAGLVERVDAVLAAGSSKMSLQRLFFVT---SLLVDCRSELGALQ--QDRKRQVTHATLR 565
            :|: .:.|....:..:      |.:..:|||:.   :..:..||:...||  .|:.....:..|.
Human   689 KWV-REHGPEHPLPRL------KYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLG 746

  Fly   566 NSPEFLE---AFRCRPGDVLYPQDQRCNP 591
            :..:|.|   ||.|       |:|...||
Human   747 SVSQFEEFGRAFHC-------PKDSPMNP 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	140/693 (20%)
ECEL1	NP_004817.2	M13	120..773	CDD:341056	142/699 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810