DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl11 and MMEL1

DIOPT Version :9

Sequence 1:	NP_649449.1	Gene:	Nepl11 / 40540	FlyBaseID:	FBgn0037230	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_258428.2	Gene:	MMEL1 / 79258	HGNCID:	14668	Length:	779	Species:	Homo sapiens

Alignment Length:	726	Identity:	136/726 - (18%)
Similarity:	251/726 - (34%)	Gaps:	229/726 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LDTSKQPCQDFYGYVC------------SHSANLSETGRQRFQSLLK---ETDVAQLMDMELQLI 88
            :|.:.:||.|||.:.|            :...::.:..|...:.:||   |...|:......:..
Human   105 MDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRDELEVILKAVLENSTAKDRPAVEKAR 169

  Fly    89 NFFKSCESGRGVEALKGSQ----LYRQSGGWPSLEPNKVNASQRTNQT-------QRWLGLLG-- 140
            ..::||.:...:|. :|||    :....||||.       |..|.|:|       :|.|.|:.
Human   170 TLYRSCMNQSVIEK-RGSQPLLDILEVVGGWPV-------AMDRWNETVGLEWELERQLALMNSQ 226

  Fly   141 -----------------------YFHE--VGAP---YFFETSVTMQSNKRLVVLQPDGTRRNTLR 177
                                   |..:  :|.|   |:|...    ||:::         |....
Human   227 FNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNGG----SNRKV---------REAYL 278

  Fly   178 KFEQRVGEVLQ--------SFGIEQSRAHVTALEVLSL-----ERSRRDIVKADH----VEDQVQ 225
            :|...|..:|:        |..:::....|..||....     :..|.|::...|    .|.|.|
Human   279 QFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQ 343

  Fly   226 FSYGNFKRIVFGNA--SLIRLDWDGYFRKLLGGKTPQASDTIVVKQLPRLVEYFALLQNTSMVRL 288
            |....|...:|...  |.:::       |||      ..:.:||..:|.|.....::...|...:
Human   344 FGLKGFNWTLFIQTVLSSVKI-------KLL------PDEEVVVYGIPYLQNLENIIDTYSARTI 395

  Fly   289 LNWIWTDYLMDIVDADCHQLSET---YAGDLYAHVVQRVT-------ANRVELAQMYSELGKAYT 343
            .|::....::|.:.:...:..:|   |...|:..:|:.|.       .|    :.|.:.:|..|.
Human   396 QNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYVN----SNMENAVGSLYV 456

  Fly   344 ---------------------------DQLGGSVWIDEISRQ-------SSRQFLGNIMHTTLNG 374
                                       |:||   |:||.|::       |.|:.:|:..:.....
Human   457 REAFPGDSKSMVRELIDKVRTVFVETLDELG---WMDEESKKKAQEKAMSIREQIGHPDYILEEM 518

  Fly   375 DERLDAAYHSILLGRRSLYRNLEKLRKFQRTRRLASHSAQQVRRYAQM------FAPVNAFLGQH 433
            :.|||..|.::.......:.|     ..|..:..|..|.:::|.....      .|.||||...:
Human   519 NRRLDEEYSNLNFSEDLYFEN-----SLQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPN 578

  Fly   434 N---------LSTP---------LNY----LLLGEFFSRSLVAAGSSSRTQG---AWRSSDSERR 473
            .         |..|         ||:    :::|...:......|.:....|   .|.|:.|.:.
Human   579 RNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQH 643

  Fly   474 FAIFQQCV-------------GKQTNAIDLLLSLLAQ----RQALSAYGQWLATQAGLVERVDAV 521
            |....:|:             .:..|..:.|...:|.    |||..||.:|:| :.|..:::..:
Human   644 FREQSECMIYQYGNYSWDLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMA-EGGKDQQLPGL 707

  Fly   522 LAAGSSKMSLQRLFFVTSLLVDCRS-----ELGALQQDRKRQVTH---ATLRNSPEFLEAFRCRP 578
                  .::.::|||:....|.|.|     .:.:::.|....:.:   .:|:|...|.:.|.|..
Human   708 ------DLTHEQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCAR 766

  Fly   579 GDVLYPQDQRC 589
            |..::|: :||
Human   767 GTPMHPK-ERC 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	133/718 (19%)
MMEL1	NP_258428.2	PepO	102..779	CDD:226118	136/726 (19%)
MMEL1	NP_258428.2	M13	111..777	CDD:189000	135/720 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810