Protein Alignment Nepl11 and PHEX

DIOPT Version :10

• Sequence 1: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Sequence 2: NP_000435.3
• Gene: PHEX / 5251
• HGNCID: 8918
• Length: 749
• Species: Homo sapiens
• Alignment Length: 709
• Identity: 138/709 - (19%)
• Similarity: 248/709 - (34%)
• Gaps: 204/709 - (28%)

  Fly    39 LDTSKQPCQDFYGYVCS----------------------HSANLSETGRQRFQSLLKETDVAQLM 81
            ::.|..||.:|:.:.|.                      |:.:|      :.:.|| |..:::..
Human    70 VNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDL------KLKELL-EKSISRRR 127

  Fly    82 DME-LQLIN-FFKSCESGRGVEALKGSQL---YRQSG-GWPSLE----PNKVNASQRTNQTQRWL 136
            |.| :|... .:.||.:.:.:|......|   .|.|. .||.||    |..|.:.::.:..|...
Human   128 DTEAIQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLA 192

  Fly   137 GLLGYFHEVGAPYFFETSVTMQSNKRLVVLQ-------------PDGTR----RNTLRKFEQRVG 184
            ...|.:........:.:.....||:.::.|.             .:.|.    |:.|.||.....
Human   193 TFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTA 257

  Fly   185 EVLQSFGIEQSRAHVTALEVLSLERSRRDI-VKADHVEDQVQFSYGNFKRIVFGNASLIRLDWDG 248
            .:|   |...|||......||.||....:| :..::...:..::..|...:   :|.:.:.||.|
Human   258 VLL---GANSSRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISEL---SAMIPQFDWLG 316

  Fly   249 YFRKLLGG------KTPQASDTIVVKQLPRLVEYFALLQNTSMVRLLNW-IWTDYLMDIVDADCH 306
            |.:|::..      |....|:.:||:......:.|.:|.:.....:.|: :|.     :|.:...
Human   317 YIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWR-----MVYSRIP 376

  Fly   307 QLSE--TYAGDLYAHVVQRVT---------ANRVELAQMYSELGKAYTD------------QLGG 348
            .||.  .|....::.|:|..|         .|.:|.|..| .:||.:.|            :|..
Human   377 NLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPY-VVGKMFVDVYFQEDKKEMMEELVE 440

  Fly   349 SV-------------WID----EISRQSSRQFLGNIMHTT-LNGDERLDAAYHSILLGRRSLYRN 395
            .|             |:|    ..:::.:|..|..:.:.. :..|..::....:|.......:.|
Human   441 GVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGN 505

  Fly   396 LEKLRKFQRTRRLASHSAQQVRR---YAQMF---APVNAFLGQHNLST----------------- 437
            :.:.||:     ||......:|:   ..:.|   ..||||   ::.||
Human   506 VLQTRKY-----LAQSDFFWLRKAVPKTEWFTNPTTVNAF---YSASTNQIRFPAGELQKPFFWG 562

  Fly   438 -----PLNY----LLLGEFFSRSLVAAGSSSRTQG---AWRSSDSERRFAIFQQCV--------- 481
                 .|:|    :::|..|:......|......|   .|.|::||.:|....:|:
Human   563 TEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYW 627

  Fly   482 --------GKQTNAIDLLLSLLAQ----RQALSAYGQWL-ATQAGLVERVDAVLAAGSSKMSLQR 533
                    ||:|     |...:|.    |:|..||.:|: ..:.||.|    .|..|.: .:..:
Human   628 KKAGLNVKGKRT-----LGENIADNGGLREAFRAYRKWINDRRQGLEE----PLLPGIT-FTNNQ 682

  Fly   534 LFFVTSLLVDCRS----------ELGALQQDRKRQVTHATLRNSPEFLEAFRCRPGDVL 582
            |||::...|.|.|          ::||....:.|  .:..:.|..||.:||.|.|...:
Human   683 LFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFR--VNGAISNFEEFQKAFNCPPNSTM 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..590	CDD:472708	137/703 (19%)
PHEX	NP_000435.3	M13	74..740	CDD:341056	137/705 (19%)