DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl11 and Nepl20

DIOPT Version :9

Sequence 1:	NP_649449.1	Gene:	Nepl11 / 40540	FlyBaseID:	FBgn0037230	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_651645.1	Gene:	Nepl20 / 43412	FlyBaseID:	FBgn0039613	Length:	700	Species:	Drosophila melanogaster

Alignment Length:	742	Identity:	140/742 - (18%)
Similarity:	255/742 - (34%)	Gaps:	220/742 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKALAVLWIAGIAYGQDDLLRVET----ELL--SFSHNLEPYLDTSKQPCQDFYGYVCSHSANLS 61
            |..|:||.:|  |...:|:|..:|    ||:  :.:..:|.:::....||:|||.:.|.:...::
  Fly    12 SHVLSVLVLA--APTSEDVLNQDTPYMKELMRQAKAAEIESFMNQKVDPCKDFYAFSCGNYKRIN 74

  Fly    62 ETGRQR------FQSLLK--ETDVAQLMDM---------ELQLINFFKSCESGRGVEALKGSQLY 109
            .....|      |::|.|  ...:.::::.         ::|:.:|::||...:.:.:....:|.
  Fly    75 SALNMRVLTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDIQVKHFYESCLQIKELNSTYSEKLK 139

  Fly   110 R---QSGGWPSLEPNK--------VNASQRTNQTQRWLGLLGYFHEVGAPYFFETSVTMQSNKRL 163
            |   :.|..|.||.:.        :|.:.|.......:.::|    ||....|     ..:.|.:
  Fly   140 RLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAHRYGIMSIIG----VGVATDF-----ANNQKNI 195

  Fly   164 VVLQ----PDGTRRNTL--------RKFEQRVGEVLQSF-GIEQSRAHVTALEVLSLERSRRDIV 215
            :.:.    |..||...:        :.::..:..:|:.: |::...|...|.|:...|
  Fly   196 IYINQQEFPLKTRSMYMDNETAIYRQNYQNNIQLILEKYLGVKDELARKAAKEMFEFE------- 253

  Fly   216 KADHVEDQVQFSYGNFKRIVFGNASL-------------IR------LDWDGYFRKLLGGKTPQA 261
                    |..::|    :|..|..|             :|      ||.|......:|.|   .
  Fly   254 --------VDLAHG----LVDNNKHLNLRDLIELLTVAELRERYAPTLDTDQLIFVSMGEK---I 303

  Fly   262 SDTIVV---KQLPRLVEYFALLQNTSMVRLLNWIWTDYLMDIVDAD----------CHQLSETYA 313
            ||.:..   :....|||   :::.|....:.|:::...:.:.:...          |...::||.
  Fly   304 SDKVYEYNRRYQQNLVE---VIERTPKSTVANYLFLRLIWEFIQKPSGVAEKPTEACVDFTKTYF 365

  Fly   314 GDLYAHVVQRVTANRV---ELAQMYSELGKAYTDQLGGSVWIDEISRQSSRQFLGNIMHTTLNGD 375
            .....:::.|...|..   |:..|:.:|...:.:.|..|..:|.|...:....:..:...||..:
  Fly   366 AKNLDNMIYRRYKNEKSSREIDSMWHQLKSTFKETLLSSPALDWIEPSTRSLAIAKLEAMTLEVN 430

  Fly   376 ----ERLDAAYHSILLGRRSLYRNLEKLRKFQRTRRLASHSAQQVRR-YAQMFAPVNAFLGQHNL 435
                |.....:..:.|.......||.:::..|         |:|:|: |.|...|:.|  |:...
  Fly   431 NYVKENFTEEFADLNLQNTDCVENLRQVQMLQ---------AKQMRQLYHQPAKPLEA--GELLS 484

  Fly   436 STPLNYL----------LLGEFF------------------------------SRSLVAAGSSSR 460
            .||.|.|          ||..|:                              .|.....|:|.
  Fly   485 YTPSNILLENSIKVPVALLQPFYIWSDVYPNAVMFGTLAYLIGHELIHGFDDSGRKFDEKGNSK- 548

  Fly   461 TQGAWRSSDSERRFAIFQQCVGKQ-----TNAIDLLLSLL---------AQRQALSAYGQWLATQ 511
               .|....|...|...:.|..||     .:.|.|..|..         ..|.|.:||.:|...|
  Fly   549 ---DWWDEKSSSNFLKRRDCFTKQYGRYVYDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQ 610

  Fly   512 AGLVERVDAVLAAGSSKM----------SLQRLFFVT---SLLVDCRSELGALQ------QDRKR 557
                    ..|..|:..|          :.::|||::   |...|...::.|||      ...|.
  Fly   611 --------LTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDVHPKVKALQVSTDDHMPGKF 667

  Fly   558 QVTHATLRNSPEFLEAFRCRPGDVLYP 584
            :|. .||.|..||.:.|.|..|..:.|
  Fly   668 RVI-GTLSNFEEFSKEFNCHAGSAMNP 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	128/694 (18%)
Nepl20	NP_651645.1	PepO	50..691	CDD:226118	127/698 (18%)
Nepl20	NP_651645.1	M13	56..697	CDD:189000	128/696 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910