DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl11 and MME

DIOPT Version :9

Sequence 1:	NP_649449.1	Gene:	Nepl11 / 40540	FlyBaseID:	FBgn0037230	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_000893.2	Gene:	MME / 4311	HGNCID:	7154	Length:	750	Species:	Homo sapiens

Alignment Length:	790	Identity:	152/790 - (19%)
Similarity:	267/790 - (33%)	Gaps:	273/790 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ISKALAVLWIAGIAYGQ-------DDLLRVETELLSFSHNLEPYLDTSKQPCQDFYGYVCSHSAN 59
            ||.::.||.:..||...       ||.:...::.:..:..|...:|.:.:||.||:.|.|.....
Human    29 ISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLK 93

  Fly    60 ---LSETG---------RQRFQSLLKET-------DVAQLMDMELQLINFFKSCESGRGVEALKG 105
               :.||.         |...:.:||:.       |:..:...:.    .::||.:...:::..|
Human    94 RNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKA----LYRSCINESAIDSRGG 154

  Fly   106 SQLYR---QSGGWPSLEPNKVNASQRTNQTQRWLGLLGYFHEVGAPYFFETSVTMQSNK------ 161
            ..|.:   ...|||.             .|:.|      ..:.||.:..|.::...::|
Human   155 EPLLKLLPDIYGWPV-------------ATENW------EQKYGASWTAEKAIAQLNSKYGKKVL 200

  Fly   162 -RLVVLQPDGTRRNTLRKFEQ-RVG----EVLQSFGI--EQSRAHV------------------- 199
             .|.|...|....|.:...:| |:|    :..:..||  |...|:|
Human   201 INLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPID 265

  Fly   200 ---TALEVLSLERSRRDIVKAD-HVED--------------QVQ-----------FSYGNFKRIV 235
               .|||:..:....::|..|. ..||              |:|           ||:.||...:
Human   266 ENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEI 330

  Fly   236 FGNASLIRLDWDGYFRKLLGGKTPQASDTIV------VKQLPRLVEYFAL-LQNTSMVRLLNWIW 293
            ....::               ......|.:|      .|..|.|.:|.|. |||     |::|
Human   331 MSTVNI---------------SITNEEDVVVYAPEYLTKLKPILTKYSARDLQN-----LMSW-- 373

  Fly   294 TDYLMDIVDADCHQLSETYAGD-------LYAHVVQRVT----ANRVELAQMYSELGKAYTD--- 344
             .::||:|.:    ||.||...       ||....:..|    ||.|. ..|.:.:|:.|.:
Human   374 -RFIMDLVSS----LSRTYKESRNAFRKALYGTTSETATWRRCANYVN-GNMENAVGRLYVEAAF 432

  Fly   345 ---------------------QLGGSVWID-EISRQSSRQFLG-----NIMHTTLNGDERLDAAY 382
                                 .|....|:| |..:::..:.|.     ......::.|.:|:..|
Human   433 AGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEY 497

  Fly   383 HSILLGRRSLYRNLEKLRKFQRTRRLASHSAQQVR------RYAQMFAPVNAFL--GQHNL---- 435
            ..:.......:.|:.:..||.::::|     :::|      .:....|.||||.  |::.:
Human   498 LELNYKEDEYFENIIQNLKFSQSKQL-----KKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPA 557

  Fly   436 ------------STPLNY----LLLGEFFSRSLVAAGSSSRTQG---AWRSSDSERRFAIFQQCV 481
                        |..|||    :::|...:......|.:....|   .|.:..|...|....||:
Human   558 GILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCM 622

  Fly   482 -------------GKQTNAIDLLLSLLAQR----QALSAYGQWLAT--QAGLVERVDAVLAAGSS 527
                         |:..|.|:.|...:|..    ||..||..::..  :..|:..:|
Human   623 VYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLD-------- 679

  Fly   528 KMSLQRLFFVTSLLVDC---RSE--LGALQQDRKRQVTHA--------TLRNSPEFLEAFRCRPG 579
             ::.::|||:....|.|   |.|  :.:::.|     .|:        ||:||.||.|||.||..
Human   680 -LNHKQLFFLNFAQVWCGTYRPEYAVNSIKTD-----VHSPGNFRIIGTLQNSAEFSEAFHCRKN 738

  Fly   580 DVLYPQDQRC 589
            ..:.| :::|
Human   739 SYMNP-EKKC 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	141/738 (19%)
MME	NP_000893.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:189000	142/740 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810