DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl11 and Nepl13

DIOPT Version :9

Sequence 1:	NP_649449.1	Gene:	Nepl11 / 40540	FlyBaseID:	FBgn0037230	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster

Alignment Length:	730	Identity:	139/730 - (19%)
Similarity:	258/730 - (35%)	Gaps:	227/730 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 NLEPYLDTSKQPCQDFYGYVCSHSANLSETGRQRFQSLLKE--TDVAQLMDMELQLINFFKSCES 96
            :::.|::.|..||.||:.|.|      .:.||...:.|..:  :...|||:.::.
  Fly    59 DVQKYMNLSADPCTDFFEYAC------GQWGRYHKRQLRPDELSTAQQLMETKIS---------- 107

  Fly    97 GRGVEALKGSQLYRQSGGWPSLEPNKVNASQRTNQTQRWLGLLGYFHEVGAPYFFETSVTMQSN- 160
                |.|:  ||..|... |...||..:.:..||           ..:|.|  |:|:.|.:::|
  Fly   108 ----EQLQ--QLLTQPLP-PQHHPNGYSGASMTN-----------VRKVRA--FYESCVAVEANA 152

  Fly   161 ---KRLV--VLQPDGTRRNT-------LRKFEQRVGEVLQSFGIEQSRAHVTALEV-LSLERSRR 212
               :|.:  :|:.:|..||.       .|::.|.:||:.:::|::    .:..||: |:|:..:.
  Fly   153 SERRRFLMKILKDNGGLRNVPNSNWQHNRQWVQTLGELRRNYGLD----ILLGLEIDLNLQTMKG 213

  Fly   213 D----------IVKADH------------------VEDQVQFSYGNFKRIVFGNAS-----LIRL 244
            :          |:.|:|                  |:.||..:..::..:..|.|:     :||.
  Fly   214 NTIYFGEPKLTIIPAEHCNALATRGAQVRDEVYELVQQQVTENLRDWFGMDTGEAARFAGDIIRF 278

  Fly   245 DWD----------------------------------GYFRKLLGGKTPQASDTIVVKQL--PRL 273
            :::                                  ...|:..||.|.....:.:...|  ..|
  Fly   279 EFELCKQMGEQDIQKPEEEFPPAIQAQIYGARSRTGQERLRRQKGGMTLTELTSEMGNHLDFKML 343

  Fly   274 VEYFALLQNTSMVRLLNWIWTDYLMDIVDAD-------------------------------CHQ 307
            ||.....|..|.|.|.:..:..:::..|.|:                               |.|
  Fly   344 VEVILESQYPSQVYLRSPEYVKHVVRTVKANNRITVGGYILYVALNELNQPPEEAPSQRARQCVQ 408

  Fly   308 LSE----TYAGDLYAHVVQRVTANRVELAQMYSELGKAYTDQLGGSVWIDEISRQSSRQFLGNIM 368
            :::    ...|:::...|||..|.. :|..:::::.||..:|.... |:||..|:::|..|....
  Fly   409 VTQRLFPQVLGEMFQRHVQRDNAKH-DLDAVFNDVIKALEEQFHVE-WMDENDRRAARTRLSQYR 471

  Fly   369 HTTLNGDERLDAAYHSILLGRRSLYRNLEKLRKFQRTRRLASHSAQQVRR---YAQMFAPVNAF- 429
            .:..:        |.|:.|......::.:..|:.:...:..||...:..|   :.|....::||
  Fly   472 VSLPD--------YQSLDLTDLQFQKSEDYWRRLEIALKYRSHQQFEALRGNDFGQDADGLDAFE 528

  Fly   430 -------------LGQHNLSTP---------LNYLLLGEFFSRSLVAA----GSSSRTQGA--WR 466
                         :|...|..|         |.|.|||...:.:||.|    |.::..|..  |.
  Fly   529 VRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDEGWNNHPQATAQWN 593

  Fly   467 S-------SDSERRFAIFQQCV----GKQTNAIDLLLSLLAQ----RQALSAYGQWLATQAGLVE 516
            .       :.||.:.|.:...:    |:..|| ..|..::|.    ..|.:||..||..|...:.
  Fly   594 EVTMSGYRNASECQRAQYSSYLYNEPGEFRNA-TRLREIIADGSGLNLAFNAYLAWLEQQDHKLR 657

  Fly   517 RVDAVLAAGSSKMSLQRLFFVTSLLVDCRSE---------LGALQQDRKRQVTHATLRNSPEFLE 572
            .:.|.........:..:|||:......|.::         :..:|...:|...:..|.||.||..
  Fly   658 PLLAKETLSELNFTNTQLFFIYFAQTRCWAKDNQDAILDSMPLMQHTPERWDVNGPLSNSAEFGR 722

  Fly   573 AFRCRPGDVLYPQDQ 587
            .|.|..|..:...|:
  Fly   723 EFGCALGTPMNSGDK 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	137/719 (19%)
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	138/719 (19%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	137/721 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910