DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl11 and Nep4

DIOPT Version :9

Sequence 1:	NP_649449.1	Gene:	Nepl11 / 40540	FlyBaseID:	FBgn0037230	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_650904.3	Gene:	Nep4 / 42449	FlyBaseID:	FBgn0038818	Length:	1040	Species:	Drosophila melanogaster

Alignment Length:	855	Identity:	159/855 - (18%)
Similarity:	277/855 - (32%)	Gaps:	320/855 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ISKALAVLWIAGIAYGQDDLLRVETELLSFSHNLEPYLDTSKQPCQDFYGYVCS----------- 55
            ||:|.|.|.......|..:.:|     ::.:..::.|:|....||.|||.|.|.
  Fly   238 ISEATAALQSFWNEEGTREGIR-----MTQAKTMKRYMDNKVDPCVDFYKYACGNWERLHPIPKD 297

  Fly    56 ----------------------------HSA-------------NLSETG--------------- 64
                                        |||             .|:|.|
  Fly   298 KAGFDTFEMLRESLDLVLRNLLEKNTPVHSAAELRKSPVRNTLFKLNEQGEGEGEADQAAELTAE 362

  Fly    65 ---------RQRFQSLL-----------------------KETDVA------------------Q 79
                     ||....:|                       ||.:.|                  |
  Fly   363 RLRRHIVSKRQLLNRVLVRYKRYTNGTKRKRLIETPRERTKEEEAAPPVVLPKDKTKDKSDNEEQ 427

  Fly    80 L----------MDMELQLINFFKSCESG-----RGVEALKGSQLYRQSGGWPSLEPNKVNASQRT 129
            |          .|.:|:..|.::||.:.     ||:|.|  ..|.|:.||||.||      ||.:
  Fly   428 LHVPTDFLKPHQDAQLKAKNLYRSCVNSAVLAKRGLEPL--HTLIRELGGWPVLE------SQWS 484

  Fly   130 NQTQRWLGLLGYFHE----------VGAP---------YFFETSVTMQSNKRLVVLQPDGTRRNT 175
            .....|..|......          |||.         .|.:|.:.:.:  |...|||...:  .
  Fly   485 ESNFNWQVLAATLRRYNNDILIVQWVGADIKNSEENIVQFDQTGLGLPT--REYFLQPSNAK--Y 545

  Fly   176 LRKFEQRVGEVLQSFGIEQSRAHVTALEVLSLE----------RSRRDIVKADHVEDQVQFSYGN 230
            |:.:::.:.||:...|..::.|...|.|:::.|          ..|.::.|.
  Fly   546 LQAYQRYMAEVMHKMGASKADAQRVASELVAFETQLAGITAPAEQRLNVTKL------------- 597

  Fly   231 FKRIVFGNASLI--RLDWDGYF-----RKLLGGKTPQASDTIVVKQLPRLVEYFALLQNT---SM 285
            :||:.......:  .:.|..|.     |::||      ::.:|:..:..:.:...||..|   ::
  Fly   598 YKRMTLDQLQAVVPEIKWRAYLQSLQDREVLG------TEEVVIYAVEYMSKLVTLLDETDPRTV 656

  Fly   286 VRLLNWIWTDYLMDIVDADCHQLSETYAGDLYAH---------VVQRVTAN-------------- 327
            ...:.|.:..:.::.||.....:.:::...|:..         .:.:|..|
  Fly   657 SNYMMWRFVRHRINNVDDRFDDIKQSFYHALFGREESPQRWKVCIAQVNTNMGMAVGSMFVSRYF 721

  Fly   328 ----RVELAQMYSELGKAYTDQLGGSVWIDEISRQSSRQFLGNIMHTTLNGDERLDAAYHSILLG 388
                :.:..:|..:|.:|:.|.|..:.|:|:.::|.:.:.: |.|        .|...|...:|.
  Fly   722 DNNSKRDTLRMTHDLQQAFRDILKTTDWLDDTTKQLAEEKV-NAM--------SLKIGYPDFILN 777

  Fly   389 RRSL---YRNLE--KLRKFQRTRRLASHSA--------QQVRRYAQMFAP--VNAFLGQHN---- 434
            ...|   |..:|  ..:.|:.|..:..|:|        ::|.:.....||  |||:..::.
  Fly   778 PSELNSKYAGIEIYPEKYFENTLNVLLHTAKTEQAKLHERVNKTNWQTAPAIVNAYYSRNKNQIM 842

  Fly   435 -----LSTP---------LNY----LLLGEFFSRSLVAAGSSSRTQG---AWRSSDSERRFAIFQ 478
                 |..|         ||:    :::|...:......|......|   .|.:..|.|.|....
  Fly   843 FPAGILQPPFYHRHFPKSLNFGGIGVVIGHELTHGFDDKGRLFDRNGNIHKWWTDSSIRGFDERA 907

  Fly   479 QCVGKQ-----TNAIDLLLS-------LLAQ----RQALSAYGQWLATQAGLVERVDAVLAAGSS 527
            :|:..|     ...:.::|:       .:|.    |||..||.:||......|.  |.:|.  ..
  Fly   908 RCIIAQYSNYTVEEVGIVLNGESTQGENIADNGGLRQAFHAYQRWLKEHPSEVS--DEILP--GL 968

  Fly   528 KMSLQRLFFVTSLLVDCRSELGALQQDRKRQ----VTHA--------TLRNSPEFLEAFRCRPGD 580
            .|:..:|||:....|.|    ||::.:..|.    ..|:        ||.||.:|...|.|..|.
  Fly   969 NMTGPQLFFLNFGQVWC----GAMRPEAIRNKLNTAIHSPGRFRVIGTLSNSVDFAREFNCPLGS 1029

  Fly   581 VLYPQDQRCN 590
            .:.|| ::|:
  Fly  1030 PMNPQ-KKCS 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	149/809 (18%)
Nep4	NP_650904.3	M13	274..1038	CDD:189000	149/812 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910