DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl11 and Ece2

DIOPT Version :9

Sequence 1:	NP_649449.1	Gene:	Nepl11 / 40540	FlyBaseID:	FBgn0037230	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_006248635.1	Gene:	Ece2 / 408243	RGDID:	1303039	Length:	912	Species:	Rattus norvegicus

Alignment Length:	736	Identity:	152/736 - (20%)
Similarity:	248/736 - (33%)	Gaps:	203/736 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LAVLWIAGIAYGQDDL---------LRVETELLSFSHNLEPYLDTSKQPCQDFYGYVCSH--SAN 59
            |..||   :.|.:|.:         :||..::|.       .||....||||||.:.|..  ..|
  Rat   225 LVALW---VQYHRDPVHSTCITEACIRVAGKILE-------SLDRGVSPCQDFYQFSCGGWIRRN 279

  Fly    60 LSETGRQRFQS--------------LLKETDVAQLMDMELQLINFFKSCESGRGVEALKG---SQ 107
            ...:||.|:.:              ||:.:......:.|.:..:|:.||.....:|.|..   ..
  Rat   280 PLPSGRSRWNTFNSLWDQNQAILKHLLENSTFNSSSEAERKTRSFYLSCLHLERIEKLGAKPLQD 344

  Fly   108 LYRQSGGW----PSLEPNKVNASQRTNQTQRWLGLLGYFHEVGAPYF--FETSVTMQSNKRLVVL 166
            |..:.|||    |..|.|.:...:....|.|           .||:|  :..:.:..||..::.:
  Rat   345 LIDKIGGWNITGPWDEDNFMEVLKAVAGTYR-----------AAPFFTVYVGADSKSSNSNIIQV 398

  Fly   167 QPDG-------------TRRNTLRKFEQRVGEVLQSFGIEQSRAHVTALEVLSLE---------- 208
            ...|             .....|..:...:.|:....|.:.:.......:||.||
  Rat   399 DQSGLFLPSRDYYLNRTANEKVLAAYLDYMVELGMLLGGQPTSTRAQMQQVLELEIQLATITVPQ 463

  Fly   209 RSRRDIVKADHVEDQVQFSYGNFKRIVFGNASLIRLDWDGYFRKLLGGKTPQASDTIVVKQLPRL 273
            ..|||..|..|     :.|....:.:.      ..:||..:...||.......|:.:||.....|
  Rat   464 DQRRDEEKIYH-----KMSISELQTLA------PSMDWLEFLSFLLSPLELGDSEPVVVYGTEYL 517

  Fly   274 VEYFALLQNTSMVRLLNW-IW------TDYLMDIVDADCHQLSETY------------------- 312
            .:...|:..|....|.|: ||      |..|....:....:|.||.
  Rat   518 QQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQTCISNTD 582

  Fly   313 ------AGDLYAHVVQRVTANR--VELAQ-MYSELGKAYTDQLGGSVWIDEISRQSSRQFLGNIM 368
                  .|.|:.    :.|.:|  .|:|: |.||:..|:.:.|...||:||.:|.::::....|.
  Rat   583 DALGFALGSLFV----KATFDRQSKEIAEGMISEIRAAFEETLENLVWMDEKTRLAAKEKADAIY 643

  Fly   369 HTTLNGD-----ERLDAAYHSILLGRRSLYRNLEKLRKFQRTRRLASHSAQQVRR------YAQM 422
            ......|     ..||..|....:...|.::|:..|..|.     |...|.|:|:      ::..
  Rat   644 DMIGFPDFILEPRELDDVYDGYEVSEDSFFQNMLNLYNFS-----AKVMADQLRKPPSRDQWSMT 703

  Fly   423 FAPVNAF------------------LGQHNLSTPLNY----LLLGEFFSRSLVAAGSSSRTQG-- 463
            ...|||:                  ...||....||:    :::|...:.:....|.....:|
  Rat   704 PQTVNAYYLPTKNEIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDQEGNL 768

  Fly   464 -AWRSSDSERRFAIFQQCV----------GKQTNAIDLLLSLLAQ----RQALSAYGQWLATQAG 513
             .|..::|...|.....|:          |::.|.:..|...:|.    :.|.:||..|| .:.|
  Rat   769 RPWWQNESLTAFQNHTACMEEQYNQYQVNGERLNGLQTLGENIADNGGLKAAYNAYKAWL-RKHG 832

  Fly   514 LVERVDAVLAAGSSKMSLQRLFFVTSLLVDCRSELGALQQDRKRQVT--HA--------TLRNSP 568
            ..:.:.||      .::..:||||....|.|  .:...:...:..||  |:        ||.||.
  Rat   833 EEQPLPAV------GLTNHQLFFVGFAQVWC--SVRTPESSHEGLVTDPHSPARFRVLGTLSNSR 889

  Fly   569 EFLEAFRCRPGDVLYPQDQRC 589
            :||..|.|..|..:.| .|.|
  Rat   890 DFLRHFGCPVGSPMNP-GQLC 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	141/686 (21%)
Ece2	XP_006248635.1	AdoMet_MTases	63..>128	CDD:302624
		PepO	250..903	CDD:226118	142/699 (20%)
		M13	261..910	CDD:189000	142/690 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900