DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl11 and phex

DIOPT Version :9

Sequence 1:	NP_649449.1	Gene:	Nepl11 / 40540	FlyBaseID:	FBgn0037230	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001307259.1	Gene:	phex / 386969	ZFINID:	ZDB-GENE-030103-2	Length:	745	Species:	Danio rerio

Alignment Length:	761	Identity:	147/761 - (19%)
Similarity:	252/761 - (33%)	Gaps:	224/761 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ISKALAVLWIAGIAYGQDDLLRVETELLSFSHNLEPYLDTSKQPCQDFYGYVC------------ 54
            |:..:||:.::..|..:|  |.:....:..:.::...:|.|..||.|||.|.|
Zfish    33 IALLIAVITVSQKASNED--LCLGPHCVEAAGSILSKMDQSVDPCDDFYQYACGGWLRENPIPED 95

  Fly    55 SHSANLSETGRQRFQSLLKETDVAQLMDMELQLIN----FFKSC--ESGRGVE----ALKGSQLY 109
            |.|..:....||.....|||.....:...:::.:.    .:.||  ||...:|    .||  .|.
Zfish    96 SSSYGIYPWLRQNVDLKLKELLEQPVRSGDIEAVKKAKVLYASCMNESALEIEDANPLLK--NLK 158

  Fly   110 RQSGGWPSLEPNKVNASQRTNQTQRWLGLLGYFHEVGAPYFFETSVTMQSNKRLVVLQPDGTRRN 174
            ::...||.| .:.:.:|.|..::|  ..||....::.:.:  ..||.:    ||.|...|.....
Zfish   159 QKEFRWPVL-GDALGSSSRWVESQ--FNLLETLAQIRSQH--SKSVLI----RLFVAPDDKNSNQ 214

  Fly   175 TLRKFEQR---------------------------VGEVLQSFGIEQSRAHVTALEVLSLERSRR 212
            .:.|.:|.                           :.:|....|..:..|......||..|....
Zfish   215 YIIKLDQASLSLSSREDYITNTTEAQMYREALLRLMVDVSVMLGASEQAAEAQMKSVLDFEMKLA 279

  Fly   213 DIVKADHVEDQVQFSYGN-FKRIVFGNASLIRL-------DWDGYFRKLLGGKT-P----QASDT 264
            .||          ..|.| ....::...||.:|       :|.|:.|.::..:. |    .:|:.
Zfish   280 QIV----------IPYENRTSENMYNKYSLSKLQRTVPDFNWLGFVRAVIDTELYPDLKISSSEQ 334

  Fly   265 IVVKQLPRLVEYFALLQNTSMVRLLNW-IWTDYLMDIVDADCHQLSETYAGDLYAHV-VQRVT-- 325
            ::|:......:.|.|:..|....:.|: ||......|.     .||..:   ||.:: ..|||
Zfish   335 VIVRAPQYFKDLFKLINATDTRTVANYVIWRSVFSRIT-----TLSRRF---LYRYLDFARVTTG 391

  Fly   326 -----------ANRVELAQMYSELGKAYTDQ-------------LGG------------SVWIDE 354
                       .|.||...:|: .|:.:.|:             :.|            :.|:||
Zfish   392 TTSLTPRWDKCVNYVENTLIYA-AGRLFVDKHFQEDKKHMMEELINGIRWAFIDILEKENEWMDE 455

  Fly   355 ISRQSS----------------------------------RQFLGNIMHTTLNGDERLDAAYHSI 385
            .:::.:                                  ..:.||:|. ||....:.|..:...
Zfish   456 ETKRKAIDKAHAVLPKVGYPDFILNDTYINEDIKRLAFTMTDYFGNVMQ-TLKFIAQSDIGWLRK 519

  Fly   386 LLGRRSLYRNLEKLRKFQRTRRLASHSAQQVRRYA-QMFAPVNAFLGQHNLSTPLNYLLLGEFFS 449
            .:.|...:.|...:..|.      |.|..|:|..| ::..|   |....|....|:|..:|....
Zfish   520 TVPRTEWFTNPTTVNAFY------SSSTNQIRFPAGELQKP---FFWGLNYPRSLSYGAIGVIVG 575

  Fly   450 RSLVAA----GSSSRTQG---AWRSSDSERRFAIFQQCV-----------------GKQTNAIDL 490
            ..|...    |......|   .|.|:.|..||....||:                 ||:|
Zfish   576 HELTHGFDNNGRKYDKDGNLDQWWSNSSINRFTEKTQCMIDQYNSYYWKEAGLNVKGKRT----- 635

  Fly   491 LLSLLAQ----RQALSAYGQWLATQAGLVERVDAVLAAGSSKMSLQRLFFVTSLLVDCRSELGAL 551
            |...:|.    |::..||.:|:..:.|.||.   .|..|.. ::..:|||::...|.|.:.....
Zfish   636 LAENIADNGGIRESFRAYRRWVEKERGGVEE---PLLPGVG-LTHNQLFFLSYAHVRCNAYRPEA 696

  Fly   552 QQDRKRQVTHA--------TLRNSPEFLEAFRCRPGDVLYPQDQRC 589
            .:|:.:...|:        .:.|..||.:||.|....::....:.|
Zfish   697 ARDQIQSGAHSPPKYRVIGAMSNFEEFRKAFNCPETSIMNRGAESC 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	138/716 (19%)
phex	NP_001307259.1	PepO	61..744	CDD:226118	141/731 (19%)
phex	NP_001307259.1	M13	72..743	CDD:189000	139/720 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900