Protein Alignment Nepl11 and KEL

DIOPT Version :9

• Sequence 1: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Sequence 2: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Alignment Length: 713
• Identity: 140/713 - (19%)
• Similarity: 232/713 - (32%)
• Gaps: 240/713 - (33%)

  Fly    40 DTSKQPCQDFYGYVCSHS-------ANLSETGRQRFQSLLKETDVAQLMDMELQLINFFKSC--- 94
            :||..||.||:.:.|..:       ..|:...:.|.:.:|:..:.......|.:...|:.||
Human   106 NTSVAPCTDFFSFACGRAKETNNSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDT 170

  Fly    95 ----ESGRG-----VEALKGSQLYRQSGGWPSLEPNKV---------------------NASQRT 129
                .:|.|     :|.|.|   :|.||.|.||..|:.                     .||..|
Human   171 LAIEAAGTGPLRQVIEELGG---WRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHT 232

  Fly   130 ----------------NQTQR-----WLGLLGYFHEVGAPYFFETSVTMQSNKRLVVLQPDGTRR 173
                            :|.|:     :...|.|.:::|.....:.|...:.:...:.:    |.|
Human   233 PVIQIDQPEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISI----TSR 293

  Fly   174 --NTLRKFEQR--VGEVLQSFGIEQSRAHVTALEVL----------SLERSRRDIV-------KA 217
              ..||..|||  .|::.|...|:|.:....|::.|          ||..|:..:|       ..
Human   294 LFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNM 358

  Fly   218 DHVEDQVQFSYGNF--KRIVFGNASLIRLDWDGYF---RKLLGGKTPQASDTIVVKQLPR----- 272
            ..:.:::.....:|  ..::.|....:....|..|   |:.|..|..:.::...:...||
Human   359 SQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCV 423

  Fly   273 ---------------------------LVEYFALLQNTSMVRLLNWIWTDYLMDIVDADCHQLSE 310
                                       .::.|..:::..:.||.|..|.:             .|
Human   424 EETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMN-------------EE 475

  Fly   311 TYAGDLYAHVVQRVTANRVELAQMYSELGKAYTDQLGGSVWI--DEISRQSSRQFLGNIMHTTLN 373
            |          |.:..::|...|:          ::|.|.|.  .|::||.
Human   476 T----------QNMAQDKVAQLQV----------EMGASEWALKPELARQE-------------- 506

  Fly   374 GDERLDAAYHSILLGRRSLYRNLEKLRKFQRTRRLASHSAQQVRRYAQMFAP--VNAF--LGQHN 434
                    |:.|.||...|...|..:|..:  .|:.....|...::....:|  |||:  :..|.
Human   507 --------YNDIQLGSSFLQSVLSCVRSLR--ARIVQSFLQPHPQHRWKVSPWDVNAYYSVSDHV 561

  Fly   435 LSTPLNYLLLGEFF------SRSLVAAGSSSRTQ-----------GAWRSSDS----------ER 472
            :..|.. ||...||      :.:..||||....:           |...:.|:          :|
Human   562 VVFPAG-LLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACDNHALQEAHLCLKR 625

  Fly   473 RFAIFQQCVGKQTNAIDLLLSL--------LAQRQALSAYGQWLATQAGLVERVDAVLAAGSSKM 529
            .:|.|.  :..:|:..|.|..|        ||  .||.||.:.|....|     :.||.  |..:
Human   626 HYAAFP--LPSRTSFNDSLTFLENAADVGGLA--IALQAYSKRLLRHHG-----ETVLP--SLDL 679

  Fly   530 SLQRLFFVTSLLVDCRSELGALQQDRKRQV---THATLRNSPEFLEAFRCRPGDVLYPQDQRC 589
            |.|::||.:...|.||........|.....   .|..|.::|.|...|||..|.:|.| ..||
Human   680 SPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNP-SSRC 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	136/706 (19%)
KEL	XP_005250050.1	PepO	106..744	CDD:226118	140/713 (20%)
		M13	109..742	CDD:189000	138/710 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.770