Protein Alignment Nepl11 and Mmel1

DIOPT Version :10

• Sequence 1: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Sequence 2: NP_038811.2
• Gene: Mmel1 / 27390
• MGIID: 1351603
• Length: 766
• Species: Mus musculus
• Alignment Length: 786
• Identity: 156/786 - (19%)
• Similarity: 260/786 - (33%)
• Gaps: 253/786 - (32%)

  Fly     6 LAVLWIAGIAYGQDDLLRVETELLSFSHN-------------------------------LEPYL 39
            |..:...|:.|.....|.:.|.||.||.:                               || .:
Mouse    29 LGAIVTLGVFYSIGKQLPLLTSLLHFSWDERTVVKRALRDSSLKSDICTTPSCVIAAARILE-NM 92

  Fly    40 DTSKQPCQDFYGYVCS----HSANLSETG---------RQRFQSLLK---ETDVAQLMDMELQLI 88
            |.|:.||::||.|.|.    |.. :.||.         |...:.:||   |...:|......:..
Mouse    93 DQSRNPCENFYQYACGGWLRHHV-IPETNSRYSVFDILRDELEVILKGVLEDSTSQHRPAVEKAK 156

  Fly    89 NFFKSCESGRGVEALKGSQL---YRQSGGWPSLEPNKVNASQRTNQT-------QRWLGLLG--- 140
            ..::||.:...:|......|   .:..||||.       |..:.|:|       :|.|.:|.
Mouse   157 TLYRSCMNQSVIEKRDSEPLLSVLKMVGGWPV-------AMDKWNETMGLKWELERQLAVLNSQF 214

  Fly   141 ----------------------YFHE--VGAP---YFFETSVTMQSNKRLVVLQPDGTRRNTLRK 178
                                  |..:  :|.|   |:|:     :.|...|        |....:
Mouse   215 NRRVLIDLFIWNDDQNSSRHVIYIDQPTLGMPSREYYFQ-----EDNNHKV--------RKAYLE 266

  Fly   179 FEQRVGEVL---QSFGIEQSRAHVTALEVLSLE----------RSRRDIV----KADHVEDQVQF 226
            |...|..:|   |:...|.:.......|||.||          ..|.|:.    :.|.:|.|.:|
Mouse   267 FMTSVATMLRKDQNLSKESAMVREEMAEVLELETHLANATVPQEKRHDVTALYHRMDLMELQERF 331

  Fly   227 SYGNFKRIVFGNASLIRLDWDGYFRKLLGGKTPQ--ASDTIVVKQLPRLVEYFALLQNTSMVRLL 289
            ....|             :|..:.:.:|.....:  ..:.:||..:|.|.....::.:.|...:.
Mouse   332 GLKGF-------------NWTLFIQNVLSSVEVELFPDEEVVVYGIPYLENLEDIIDSYSARTMQ 383

  Fly   290 NWIWTDYLMDIVDADCHQLSET---YAGDLYAHVVQRV--------TANRVELA----------- 332
            |::....::|.:.:...:..|.   |...||...|:.|        ..:.:|.|
Mouse   384 NYLVWRLVLDRIGSLSQRFKEARVDYRKALYGTTVEEVRWRECVSYVNSNMESAVGSLYIKRAFS 448

  Fly   333 --------QMYSELGKAYTDQLGGSVWIDEISRQSSRQFLGNIM-------HTTLNGDERLDAAY 382
                    ::..::...:.|.|....|:||.|::.:::...||.       :...:.::.||..|
Mouse   449 KDSKSTVRELIEKIRSVFVDNLDELNWMDEESKKKAQEKAMNIREQIGYPDYILEDNNKHLDEEY 513

  Fly   383 HSILLGRRSLYRNLEKLRKFQRTRRLASHSAQQVRRYAQM------FAPVNAFLGQHN------- 434
            .|:     :.|.:|......|..:..|..|.:::|.....      .|.||||...:.
Mouse   514 SSL-----TFYEDLYFENGLQNLKNNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPNRNQIVFPA 573

  Fly   435 --LSTP---------LNY----LLLGEFFSRSLVAAGSSSRTQG---AWRSSDSERRFAIFQQCV 481
              |..|         ||:    :::|...:......|.:....|   .|.|:.|.|.|....||:
Mouse   574 GILQPPFFSKDQPQSLNFGGIGMVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSARHFQQQSQCM 638

  Fly   482 -------------GKQTNAIDLLLSLLAQ----RQALSAYGQWLATQAGLVERVDAVLAAGSSKM 529
                         .:..|....|...:|.    |||..||.:||| ..|..:|:..:      .:
Mouse   639 IYQYGNFSWELADNQNVNGFSTLGENIADNGGVRQAYKAYLRWLA-DGGKDQRLPGL------NL 696

  Fly   530 SLQRLFFVTSLLVDC---RSELGALQQDRKRQVTHA--------TLRNSPEFLEAFRCRPGDVLY 583
            :..:|||:....|.|   |.|...  |..|..| |:        :|:|.|.|.|||.|..|..::
Mouse   697 TYAQLFFINYAQVWCGSYRPEFAV--QSIKTDV-HSPLKYRVLGSLQNLPGFSEAFHCPRGSPMH 758

  Fly   584 PQDQRC 589
            |. :||
Mouse   759 PM-KRC 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..590	CDD:472708	143/716 (20%)
Mmel1	NP_038811.2	M13	97..764	CDD:341056	143/717 (20%)