Protein Alignment Nepl11 and Kel

DIOPT Version :9

• Sequence 1: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Sequence 2: NP_115929.3
• Gene: Kel / 23925
• MGIID: 1346053
• Length: 713
• Species: Mus musculus
• Alignment Length: 706
• Identity: 149/706 - (21%)
• Similarity: 238/706 - (33%)
• Gaps: 213/706 - (30%)

  Fly    35 LEPYL---DTSKQPCQDFYGYVCSHSAN--------LSETGRQRFQSLLKETDVAQLMDMELQLI 88
            |:.||   :.|..||.||:.:.| ..||        |:|..:.|...||:......|...|.:..
Mouse    67 LDHYLASGNRSVAPCTDFFSFAC-EKANGTSDSFQALTEENKSRLWRLLEAPGSWHLGSGEEKAF 130

  Fly    89 NFFKSCESGRGVEALKGS----QLYRQSGGWPSLEPNKVNASQRTNQTQRWLGLLGYFHEVGAPY 149
            .|:.||.....:|| .||    |:..:.|||              |.|..|
Mouse   131 QFYNSCMDTDAIEA-SGSGPLIQIIEELGGW--------------NITGNW-------------- 166

  Fly   150 FFETSVTMQSNKRLVV------------LQPDGTRRNT-LRKFEQRVGEVLQSFGIEQS------ 195
               ||:....|.||::            |:|.....:| :.:.:|...::|.....||.
Mouse   167 ---TSLDFNQNLRLLMSQYGHFPFFRAYLRPHPAPPHTPIIQIDQPEFDILLQQEQEQKVYAQIL 228

  Fly   196 RAHVTALEVLSLERSRRDIVKADHVEDQVQFSYGNFKRI-----------VFGNASLIRL----- 244
            |.:||.|..|.............|....:.|:...|:.:           :|...::..|
Mouse   229 REYVTYLNRLGTLLGSNPQEAQQHASWSIVFTSRLFQFLRPQQQQQAQDKLFHVVTIDELQEMAP 293

  Fly   245 --DWDGYFRKLLGGKTPQASDTIVVKQLPRLVEYFALLQNTSMV---RLLNW---IWTDYLMDIV 301
              ||....:.:....:..:|.|:||..|    :|   |:|.|.:   .|||.   |.:..::.:|
Mouse   294 AIDWLSCLQAIFTPMSLNSSQTLVVHDL----DY---LRNMSQLVEEGLLNHRESIQSYMILGLV 351

  Fly   302 DA------------------DCHQLSET-------------------YAGDLYAHVVQRVTANRV 329
            |.                  :..:|.|.                   :...|.|..|:......:
Mouse   352 DTLSPALDTKFQEARRELIQELRKLKERPPLPAYPRWMKCVEQTGAFFEPTLAALFVREAFGPSI 416

  Fly   330 ELA--QMYSELGKAYTDQLGGSVWIDEISRQSSRQFLGNIMHTTLNGDERL---DAA---YHSIL 386
            :.|  ::::|:..|...:|....||.|.:::.:...|.. :...:...:|.   |.|   |:.|.
Mouse   417 QSAAMELFAEIKDAVIIRLKKLSWISEETQKEALNKLAQ-LQVEMGAPKRAVKPDIATQEYNDIQ 480

  Fly   387 LGRRSLYRNLEKLRKFQRTRRLASHSAQQVRRYAQMF-------AP--VNAF--LGQHNLSTPLN 440
            ||...|...|..:|..:         |:.|:.:.|.|       :|  |||:  :..|.:..|..
Mouse   481 LGPSFLQSFLSCVRSLR---------ARNVQSFLQPFPYHRWQKSPWEVNAYYSISDHMVVFPAG 536

  Fly   441 YLLLGEFF------SRSLVAAGSSSRTQ-----------GAWRSSDS----------ERRFAIFQ 478
             ||...||      :.:..||||....:           |...:.|:          ||.:|.|.
Mouse   537 -LLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCPACDTHVLQEALLCLERHYAAFP 600

  Fly   479 QCVGKQTNAIDLLLSLLAQ----RQALSAYGQWLATQAGLVERVDAVLAAGSSKMSLQRLFFVTS 539
            .......|....||...|.    ..|..||.:.:....|       .|...:..:|..:|||.:.
Mouse   601 LPSISSFNGSHTLLENAADIGGVAIAFQAYSKRIVEHTG-------ELTLPNLDLSPYQLFFRSY 658

  Fly   540 LLVDCRSELGALQQDRKRQVT------HATLRNSPEFLEAFRCRPGDVLYPQDQRC 589
            ..|.||   |...||.:...:      |..|.|:|:|.:.|.|..|.:|.| ..||
Mouse   659 AQVMCR---GLSSQDPQDPHSPPSLRVHGPLSNTPDFAKHFHCPRGTLLNP-SARC 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	143/691 (21%)
Kel	NP_115929.3	M13	78..711	CDD:341056	145/695 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860