DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl11 and ECE1

DIOPT Version :9

Sequence 1:	NP_649449.1	Gene:	Nepl11 / 40540	FlyBaseID:	FBgn0037230	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens

Alignment Length:	740	Identity:	147/740 - (19%)
Similarity:	260/740 - (35%)	Gaps:	218/740 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LAVLWIAGIAYG--------QDDLLRVETELLSFSHNLEPYLDTSKQPCQDFYGYVCSH--SANL 60
            :|.|...||.|.        .:..:.|.:.:||   :::|.:|    ||.||:.|.|..  .||.
Human    89 VACLAALGIQYQTRSPSVCLSEACVSVTSSILS---SMDPTVD----PCHDFFSYACGGWIKANP 146

  Fly    61 SETGRQRF----------QSLLK---ETDVAQLMDMELQLINFFKSCESGRGVEALKGS---QLY 109
            ...|..|:          |:::|   |...|.:.:.|.:...::::|.:...:|.|:..   :|.
Human   147 VPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELI 211

  Fly   110 RQSGGWPSLEPNKVNASQRTNQTQRWLGLLGYFHEVGAPYF--FETSVTMQSNKRLVVLQPDG-- 170
            .:.|||....|...:..|.|.|...       .|...:|:|  :.::.:..||..::.:...|
Human   212 ERLGGWNITGPWAKDNFQDTLQVVT-------AHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLG 269

  Fly   171 --TRRNTLRKFEQ------------RVGEVLQSFGIEQSRAHV-------TALEVLSL-ERSRRD 213
              :|...|.|.|.            ::|::|.....|..|..:       |||..::: :..|||
Human   270 LPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRD 334

  Fly   214 IVKADHVEDQVQFSYGNFKRIVFGNASLIRL-------DWDGYFRKLLGGKTPQASDTIVVKQLP 271
                              :.:::...:...|       :|..:...:........|:.|||....
Human   335 ------------------EELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKE 381

  Fly   272 RLVEYFALLQNTSMVRLLNW-IW-----TDYLMD--IVDAD--------------------CHQL 308
            .|.:...|:..|....|.|: ||     |...:|  ..|||                    |...
Human   382 YLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSD 446

  Fly   309 SETYAGDLYAHVVQRVT---ANRVELAQMYSELGKAYTDQLGGSVWIDEISRQSSRQFLGNIMHT 370
            :|...|.....:..:.|   .::....::..|:.||:.:.|....|:||.:|:|::
Human   447 TENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAK--------- 502

  Fly   371 TLNGDERLDAAYHSILLGRRSLYRNLEKLRK------------FQRTRRLASHS----AQQVRRY 419
                 |:.||.|:  ::|..:...:.::|.|            |:...|..:.|    |.|:|:.
Human   503 -----EKADAIYN--MIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKA 560

  Fly   420 A-----QMFAP-VNAFLGQ----------------HNLSTP--LNY----LLLGEFFSRSLVAAG 456
            .     .|..| |||:...                :..|:|  ||:    :::|...:.:....|
Human   561 PNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQG 625

  Fly   457 SSSRTQG---AWRSSDSERRFAIFQQCV----------GKQTNAIDLLLSLLAQ----RQALSAY 504
            ......|   .|..:.|...|....:|:          |:..|....|...:|.    :.|..||
Human   626 REYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAY 690

  Fly   505 GQWLATQAGLVERVDAVLAAGSSKMSLQRLFFVTSLLVDC------RSELGAL----QQDRKRQV 559
            ..|       |::..|..:..:..::..:|||:....|.|      .|..|.:    ...|.|.:
Human   691 QNW-------VKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVI 748

  Fly   560 THATLRNSPEFLEAFRCRPGDVLYP 584
              .:|.||.||.|.|||.||..:.|
Human   749 --GSLSNSKEFSEHFRCPPGSPMNP 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	137/693 (20%)
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	141/711 (20%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	138/699 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810