Protein Alignment Nepl11 and nep-2

DIOPT Version :10

• Sequence 1: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Sequence 2: NP_494343.2
• Gene: nep-2 / 188090
• WormBaseID: WBGene00020230
• Length: 736
• Species: Caenorhabditis elegans
• Alignment Length: 694
• Identity: 132/694 - (19%)
• Similarity: 247/694 - (35%)
• Gaps: 175/694 - (25%)

  Fly    39 LDTSKQPCQDFYGYVC----------------SHSANLSETGRQRFQSLLKETDVAQLMDMELQL 87
            :::|..||.|||.:.|                |:..||.:......:.||.|.|  :..|.|...
 Worm    69 MNSSVDPCDDFYEFACGQWIKGHPIPDDAPSVSNFENLGQDLEFALKELLDEND--EPYDYETSA 131

  Fly    88 IN----FFKSC--ESGRGVEALKG-----SQLYRQSGGWPSL-EPNKVNASQRTNQTQRWLGLLG 140
            :.    |:..|  ||    |.|..     .::.:..|||||| ...|.:||..    ..:..::.
 Worm   132 VGKAKYFYNLCLNES----EILDNWRTTFDEVVKSFGGWPSLGHQMKPDASIE----MLYADMVA 188

  Fly   141 YFHEVGAPYFFETSVTM-QSNKRLVVLQPDGTRRNTLRK-------------FEQRVGEVLQSFG 191
            .|.   |...|:.:|.. ..|.:..||..|..:.|...:             :.|.:.:||....
 Worm   189 KFK---ADSLFKATVQPDDKNSQRHVLLIDQPQLNLFARDFYVAAENEERMAYLQLIRDVLILLD 250

  Fly   192 IEQSRAHVTALEVLSLERSRRDIVKAD-HVEDQVQFSYGNFKRIVFG--NASLIRLDWDGYFRKL 253
            .:::||.:.|.|::..|.:..:|..|| |..|..:.    :.:|..|  ..||...:|..:|.::
 Worm   251 ADRTRATLDAKEIIDFETALANITMADEHRHDIAEL----YTKITLGEMRRSLPHFNWPLFFNRM 311

  Fly   254 L------GGKTPQASDT--IVV---KQLPRLVEYFALLQNTSMVRLLNWIW-------------- 293
            .      .||.....|.  :||   :.|.||........|..:|..|.|.|
 Worm   312 FKDLHEKNGKRITFDDNTEVVVYGYEFLRRLDVLIPQYDNRLIVNYLEWCWFFKTMLRDLPDPFA 376

  Fly   294 --------TDYLMDIVDADCH------------QLSETYAGDLYAHVVQRVTANRVELAQMYSEL 338
                    |..:|::.....|            ..|..|..:.:.|..::      ::.:|.|.:
 Worm   377 LTIFKFYKTLNIMNVQKVRWHGCVTRINSLMPMATSAIYVKNHFDHEAKQ------QVEEMISLI 435

  Fly   339 GKAYTDQLGGSVWIDEISRQSSRQFLGNIMHTT-----LNGDERLDAAYHSILLGRRSLYR-NLE 397
            .:::.|.|....|:.:.::|:::|.:..:....     ||....::..|.:..:.....|: ...
 Worm   436 MESFVDLLLSEDWLTKETKQTAKQKVNEMKRKIGYPDYLNDPAAVNNEYKTFKVYPGHYYQTKFS 500

  Fly   398 KLRKFQRTRRLASHSAQQVRRYAQMFAPVNAFLGQH------------------NLSTPLNY--- 441
            ...::||........|....|:....|.||||...:                  :..:.:|:
 Worm   501 FYEQYQRDVLERITEAVDRERWVAGAALVNAFYSPNTNEIIFPAGILQPVFYSKDFPSSMNFGGI 565

  Fly   442 -LLLGEFFSRSLVAAGSSSRTQG---AWRSSDSERRFAIFQQCVGKQTNAIDLLLSLLAQRQALS 502
             :::|...:......|......|   .|..:.:..:|....||:.||.::. :|..:..|....|
 Worm   566 GVVIGHEITHGFDDRGRLYDNLGNIRQWWDNATISKFEHKAQCIEKQYSSY-VLDQINMQINGKS 629

  Fly   503 AYGQWLATQAGLVE----------------RVDAVLAAGSSKMSLQRLFFVTSLLVDC--RSELG 549
            ..|:.:|...||.:                |:..|      .::..:|||:....:.|  .::..
 Worm   630 TKGENIADNGGLKQAYRAYKKYEKRHSRPPRLPGV------NLTHDQLFFLNYAQIWCGTMNDKE 688

  Fly   550 ALQQDRKRQVTHATLR------NSPEFLEAFRCRPGDVLYPQDQ 587
            |:::.|..:.:...:|      ||.:|.:|:.|.||..:.|:::
 Worm   689 AIRKLRTSEHSPGPIRVKGPLSNSYDFAKAYNCEPGSQMNPREK 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..590	CDD:472708	131/688 (19%)
nep-2	NP_494343.2	M13	73..734	CDD:341056	131/690 (19%)