Protein Alignment Nepl11 and nep-18

DIOPT Version :9

• Sequence 1: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Sequence 2: NP_494297.1
• Gene: nep-18 / 186911
• WormBaseID: WBGene00019343
• Length: 701
• Species: Caenorhabditis elegans
• Alignment Length: 726
• Identity: 147/726 - (20%)
• Similarity: 253/726 - (34%)
• Gaps: 239/726 - (32%)

  Fly    35 LEPYLDTSKQPCQDFYGYVC----SHSANLSETGRQRFQSLL-------KETDVAQLMDMELQLI 88
            ::.|.:.|..||:||:.:.|    .|..:.:..|..:::.||       ::|:.......| ||.
 Worm    39 IKNYQNASVDPCEDFFEHTCGRYSEHVMDDNSWGYVQYKQLLYQVFAIARKTNKFNSKPNE-QLR 102

  Fly    89 NFFKSCESGRGVEALKGSQL---YRQSGGWPSLEPN----KVNASQRTNQTQRWLGL----LGYF 142
            .|.|||...:.::......|   ..:.||:|.::||    |.:.|   :...::|.:    :|:.
 Worm   103 IFTKSCLDRKEMDEDTFQDLRNDIEERGGFPMIDPNWNEEKFDLS---DMLAKYLSINRNRMGFL 164

  Fly   143 HEVGAPYFFETSVTMQSNK---RLVV---------------LQPDGT----RRNTLRKFEQR-VG 184
            ..  .||     ..::.||   ||.|               :..|..    ||  |.|.|.| :.
 Worm   165 SV--EPY-----AAIEGNKSVNRLYVSPGPHWVYNWAMGISIYKDSVAFMLRR--LLKLENRELN 220

  Fly   185 EVL--QSFG-IEQSRAHVTAL----------EVLSLERSRRDIVK--------------ADH--- 219
            |.:  :.|. :.|..|:.:.|          :.:|..|:..|:||              |.|
 Worm   221 ETIYDKEFAELVQLEANFSTLADYRNLALDNDNMSKSRNLTDLVKMIPEIDWIKILKALARHGTS 285

  Fly   220 VEDQVQFSYGNFKRIVFGNASLIRLDWDGYF----RKL--LGGKTPQA--SDTIVVKQLPRLVEY 276
            .||:.:.    .:|:....|.       .||    |:|  :..:||::  ::.:||:||..:..|
 Worm   286 EEDEEKL----LERVTVHGAG-------EYFFGENRELARIATETPKSALANYLVVRQLIDVALY 339

  Fly   277 F----------------------------------ALLQNTSMVRLLNWIWTDYLMDIVDADCHQ 307
            |                                  .:...:|..::.|....:.:...:.|:..|
 Worm   340 FYDKDQPRQNKFYNHVDQQSFCATQVASFFPMPSMNVFIESSQFKIENLKVIEEMFVKIKAEYEQ 404

  Fly   308 L---SETYAGDLYAHVVQRV------------TANRVELAQMYSELGKAYTD---QLGGSVWIDE 354
            :   :|....::...:::::            |..:..|.:||..|....||   |:...:|
 Worm   405 IFTENEYLELEIREFLIRKLNAIDGKFGLDQYTEGKPLLEKMYETLNFLDTDSPWQVYMKMW--- 466

  Fly   355 ISRQSSRQFLGNIMHTTLNGDERLD----------AAYHSILLGRRSLYRNLEKLRKFQRTRRLA 409
              |..|.|.:.:|:|     |..||          |||...   ....|.||..|
 Worm   467 --RHWSEQLVEHIVH-----DTPLDPVNLKMFGTHAAYQPY---PNHFYINLPYL---------- 511

  Fly   410 SHSAQQVRRYAQMFA--PVNAFLGQHNLSTPLNYLL---LGEFFSRSLVAAGSSSRTQGAW--RS 467
                    .|..|.|  |.|...|.      |.|::   :|..|.........|.|.|..|  .:
 Worm   512 --------TYPWMDADFPANTNYGY------LGYVIGHEIGHAFDHFHRKLDESGRQQQYWFTET 562

  Fly   468 SDSERRFAIFQQCVGKQTNA-----IDLLLSLLAQRQALSAYGQWLATQAGLVERV---DAVLAA 524
            :.|...:.:.::|:..|.:|     .|..::....|..::.....:.|...:.|:|   |.....
 Worm   563 NSSNTEYELREKCLRDQYSAYKEPGYDFFMNGTHCRYEIAGDHMGIRTAFRVFEKVKKEDRFRLP 627

  Fly   525 GSSKMSLQRLFFVTSLLVDC---------RSELGALQQDRKRQVTHATLRNSPEFLEAFRCRPGD 580
            | .:||.::|||.......|         |:.| |.|....|...:..::|.|||.|||.|
 Worm   628 G-LEMSEEQLFFYNYAFRQCDVYNPNKLPRNML-ARQHPTNRYRVNGVIQNIPEFAEAFNC---- 686

  Fly   581 VLYPQDQRCNP 591
               |::...||
 Worm   687 ---PKNSPMNP 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	143/712 (20%)
nep-18	NP_494297.1	PepO	42..692	CDD:226118	145/719 (20%)
		M13	47..699	CDD:189000	145/718 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770