Protein Alignment Nepl11 and Phex

DIOPT Version :10

• Sequence 1: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Sequence 2: NP_035207.1
• Gene: Phex / 18675
• MGIID: 107489
• Length: 749
• Species: Mus musculus
• Alignment Length: 750
• Identity: 151/750 - (20%)
• Similarity: 264/750 - (35%)
• Gaps: 216/750 - (28%)

  Fly     5 ALAVLWIAGIAYGQDDLLRVETELLSF----SHNLEP-----------YLDTSKQPCQDFYGYVC 54
            ||| |:|.|.......|..|...||||    .:.|:|           .::.|..||::|:.:.|
Mouse    22 ALA-LFIGGTLVLGTLLFLVSQGLLSFQAKQEYCLKPECIEAAAAIMSKVNLSVDPCENFFRFAC 85

  Fly    55 S----------------------HSANLSETGRQRFQSLLKETDVAQLMDME-LQLIN-FFKSCE 95
            .                      |:.:|      :.::|| |..|::..|.| :|... .:.||.
Mouse    86 DGWISNNPIPEDMPSYGVYPWLRHNVDL------KLKALL-EKSVSRRRDTEAVQKAKILYSSCM 143

  Fly    96 SGRGVEALKGSQL---YRQSG-GWPSLE----PNKVNASQRTNQTQRWLGLLGYFHEVGAPYFFE 152
            :.:.:|......|   .|.|. .||.||    |..|.:.::.:..|......|.:........:.
Mouse   144 NEKAIEKADAKPLLHILRHSPFRWPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYV 208

  Fly   153 TSVTMQSNKRLVVLQP------------DGTR-----RNTLRKFEQRVGEVLQSFGIEQSRAHVT 200
            :.....||:.::.|..            |.|.     |:.|.||......:|   |...|||...
Mouse   209 SPDDKASNEHILKLDQATLSLAVREDFLDNTTEAKSYRDALYKFMVDTAVLL---GANSSRAEHD 270

  Fly   201 ALEVLSLERSRRDI-VKADHVEDQVQFSYGNFKRIVFGNASLIRLDWDGYFRKLLGG------KT 258
            ...||.||....:| :..::...:..::..|...:   :|.:.:.||.||.:|::..      |.
Mouse   271 MKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISEL---SAMIPQFDWLGYIKKVIDTRLYPHLKD 332

  Fly   259 PQASDTIVVKQLPRLVEYFALLQNTSMVRLLNW-IWTDYLMDIVDADCHQLSE--TYAGDLYAHV 320
            ...|:.:||:......:.|.:|.......:.|: :|.     :|.:....||.  .|....::.|
Mouse   333 IGPSENVVVRVPQYFKDLFRILGAERKKTIANYLVWR-----MVYSRIPNLSRRFQYRWLEFSRV 392

  Fly   321 VQRVT---------ANRVELA-------------------QMYSELGK----AYTDQL-GGSVWI 352
            :|..|         .|.:|.|                   :|..||.:    |:.|.| ..:.|:
Mouse   393 IQGTTTLLPQWDKCVNFIESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFIDMLEKENEWM 457

  Fly   353 D----EISRQSSRQFLGNIMHTT-LNGDERLDAAYHSILLGRRSLYRNLEKLRKFQRTRRLASHS 412
            |    ..:::.:|..|..:.:.. :..|..::....:|.......:.|:.:.||:     ||...
Mouse   458 DAGTKRKAQEKARAVLAKVGYPEFIMNDTYVNEDLKAIKFSESDYFGNVLQTRKY-----LAQSD 517

  Fly   413 AQQVRR---YAQMF---APVNAFLGQHNLST----------------------PLNY----LLLG 445
            ...:|:   ..:.|   ..||||   ::.||                      .|:|    :::|
Mouse   518 FFWLRKAVPKTEWFTNPTTVNAF---YSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVG 579

  Fly   446 EFFSRSLVAAGSSSRTQG---AWRSSDSERRFAIFQQCV-----------------GKQTNAIDL 490
            ..|:......|......|   .|.|.:||.:|....:|:                 ||:|
Mouse   580 HEFTHGFDNNGRKYDKNGNLDPWWSVESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRT----- 639

  Fly   491 LLSLLAQ----RQALSAYGQWLATQAGLVERVDAVLAAGSSKMSLQRLFFVTSLLVDCRS----- 546
            |...:|.    |:|..||.:|:..:.   :.|:..|..|.: .:..:|||::...|.|.|
Mouse   640 LGENIADNGGLREAFRAYRKWINDRR---QGVEEPLLPGIT-FTNNQLFFLSYAHVRCNSYRPEA 700

  Fly   547 -----ELGALQQDRKRQVTHATLRNSPEFLEAFRC 576
                 ::||....:.|  .:..:.|..||.:||.|
Mouse   701 AREQVQIGAHSPPQFR--VNGAISNFEEFQKAFNC 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..590	CDD:472708	135/694 (19%)
Phex	NP_035207.1	M13	74..740	CDD:341056	135/696 (19%)