Protein Alignment Nepl11 and nep-8

DIOPT Version :10

• Sequence 1: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Sequence 2: NP_001309548.1
• Gene: nep-8 / 184631
• WormBaseID: WBGene00017553
• Length: 686
• Species: Caenorhabditis elegans
• Alignment Length: 667
• Identity: 117/667 - (17%)
• Similarity: 232/667 - (34%)
• Gaps: 208/667 - (31%)

  Fly    19 DDLLRV-----------ETELLSFSHNLEPYLDTSKQPCQDFYGYVCS--HSANLSETGRQRFQS 70
            |:||.:           ..|.::.||.|..|.|.|..||.||:.:.|.  |..::||:..|:.:.
 Worm    41 DELLSIGNDVDSKNLCDSPECITLSHELLNYQDPSVDPCVDFFQHSCGRFHEQSVSESRLQKKKH 105

  Fly    71 LLKETDVAQLMDMELQLIN-----------FFKSCESGRGVEALKGSQLYRQS------------ 112
            :|::    |:.:...::.|           .|..||:.:..    .:..|:.|
 Worm   106 ILRK----QIREFLHKIQNSTSKSENLMKLVFDKCEASKKT----SNDNYKISRDAIHDVFNDIK 162

  Fly   113 --GGWPSLEPNKVNASQRTNQTQRWLGLLGYFHEVGAPY--FFETSVTMQSNKRLVVLQPDGTRR 173
              |.||.|:.|...:....|:      :|....::||..  .|:....:.:..:.|.:.|
 Worm   163 KIGAWPLLDKNWDGSKFDLNE------MLSNLVKLGATNLGLFQLDFRILTEGKFVRIAP----- 216

  Fly   174 NTLRKFEQR------VGEVLQSFGIEQSRAHVTA--LEVLSLERSRRDIVKADHVEDQVQFSYG- 229
             ||......      :.|:|::.|::.....::.  .|..||:      :|....:...:.|..
 Worm   217 -TLGSIVHNSTMISMISEILEANGVQPDSEEISKEFEEYSSLQ------MKLAKYQSSGKLSISL 274

  Fly   230 ------NFKRI------------VFGNASLIRLDWDGYFRKLLGGKTPQASDTIVVKQLPRLVEY 276
                  ||..:            :||...::..:...:|:    ....::.|||:
 Worm   275 PGVRSINFSSLITEMIHPSRVSKIFGKIRVVTSEHPLFFK----SNETESLDTII---------- 325

  Fly   277 FALLQNTSMVRLLNWIWTDYLMDIVD-------ADCHQLSETYAGDL---YAHVVQRV------- 324
                ::||...|.|::..:|:....:       .:|..       |:   :.....||
 Worm   326 ----ESTSNKTLANFLIFNYIQSSYNIMKGARRGNCED-------DVRREFPRASLRVFMRNFVD 379

  Fly   325 TANRVELAQMYSELGK------AYTDQLGGSVWIDEISR-QSSRQFLGNIMHTTLNGDERLDAAY 382
            ..||..:.::..||.|      ..|:.|...|....:.: ::.:..:|...|....|  .||..:
 Worm   380 KGNRDGVKKLTEELKKNTLEMIQDTENLAPPVKESMLKKVEAIKVTIGYPDHFDPPG--TLDKEF 442

  Fly   383 HSI-LLGRRSLYRNLEKLRKFQRTRRL-----------------ASHSAQQVRRYAQMFAPVNAF 429
            .:. |....|.||..:||.:.:..:::                 .:.:.::.:....:|||   |
 Worm   443 ENFDLDSTDSYYRIFQKLNRLRSEQQMEFIAGETPISPIKEVLKVNANYKRSKNALTVFAP---F 504

  Fly   430 LGQ--HNLSTPLNYLLLGEFFSRSLVA--AGSSSRTQGA-----WRSSDSERRFAIFQ-----QC 480
            |..  .:::.| :|:.|  |||..|:|  .|.|....|.     .:..|..|...:.:     ||
 Worm   505 LDDPFFDITYP-DYVNL--FFSGFLIAHEIGHSVDANGLGYDENGKPMDGIRLEHVTEYGKQGQC 566

  Fly   481 V------------GKQTNAIDLLLSLLAQRQALSAYGQWLATQA--GLVERVDA---VLAAGSSK 528
            :            ||:.|....:..::|         .|:..:.  ...:::|.   :...|...
 Worm   567 LVDQYDNYDDPVYGKKMNGTHSINEIIA---------DWVGHEVTWRAYKKMDTSKMLSLIGLKD 622

  Fly   529 MSLQRLFFVTSLLVDCR 545
            :::.:|:|....|:.||
 Worm   623 INMDQLYFRVQSLLFCR 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..590	CDD:472708	107/630 (17%)
nep-8	NP_001309548.1	M13	76..664	CDD:341056	107/632 (17%)