Protein Alignment Nepl11 and nep-22

DIOPT Version :10

• Sequence 1: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Sequence 2: NP_509528.1
• Gene: nep-22 / 181144
• WormBaseID: WBGene00020788
• Length: 798
• Species: Caenorhabditis elegans
• Alignment Length: 750
• Identity: 155/750 - (20%)
• Similarity: 245/750 - (32%)
• Gaps: 235/750 - (31%)

  Fly    39 LDTSKQPCQDFYGYVCS---HSANLSETGRQR--------------FQSLLKETDVAQLMDMELQ 86
            ||.:..||||||.:.|:   .:.:|.:.||.|              ..:.|.:.||......:.:
 Worm    79 LDDTVDPCQDFYAFTCNKFLQNTDLQKLGRSRLGTYDQAQVDVYSEIVAALSKIDVTSTTTSKTE 143

  Fly    87 LIN--FFKSCESGRGVEALKGSQLYRQ----SGGWPSL-EPNKVNASQRTNQTQRWL--GLLGYF 142
            .|.  .|::|::.....|.|.:.:|.:    .||.|.. ||.|.|...       |:  |.:...
 Worm   144 RITKAAFETCKNNLASPADKTAVVYAEITSLFGGVPFFGEPLKTNVDY-------WMVAGQIEQK 201

  Fly   143 HEVGA-PYFFETSVTMQSNKRLVVLQPDG--------TRRNTLRKFEQRVGEV---LQSFGIEQS 195
            |.||. .|...:|......|..:...|.|        .:...:.:..|||.:|   |.:|. ..:
 Worm   202 HAVGTLTYTIASSDYKDHTKNALYTGPPGLSLARDFYVKPQYIAEVNQRVSDVNDLLTAFA-NAA 265

  Fly   196 RAHV-------TALEVLSLERSRRDIVKADHVED-----QVQFSYGNFKRIVFGNASLIRLDWDG 248
            :.:|       .|.||::.|   ..|..|...:|     |.|::..|   |.....:...::|..
 Worm   266 KKNVGADALLAAAQEVVNFE---VQIAMASWPDDLLRNYQQQYNPYN---IASATTAYRAINWKS 324

  Fly   249 YFRKLLGG---KTPQASDTIVVKQLPRLVEYFALLQ--------------NTSMVRLL------- 289
            |..:|..|   ...||:..|||.:    ..|||.|.              |..:.:||
 Worm   325 YLGQLFHGVASDADQANYNIVVTE----PSYFAWLNSVFDGKTSNSTVVANYMIAQLLADESDFI 385

  Fly   290 -----------NWIW--------------TDYLM---DIVDADCHQLSETYA--GDLYAHVVQRV 324
                       |:|.              .:|.|   |.:...|..|...|.  |..|.:|..:.
 Worm   386 NPATAKVSSDTNYIHYALRNGRGIKKIGKREYRMADLDGISEGCMDLLTAYMPYGTGYVYVKSKS 450

  Fly   325 TANRV--ELAQMYSELGKAYTDQLGGSVWIDEISR----QSSRQFLGNI-----MHTTLNGDERL 378
            ..|:|  ::....:.:...:...:....|:|..|:    ..|...:.|.     |....|....:
 Worm   451 ERNKVQADVKDQTTLIINNFQGMIDSLNWMDTFSKNRAHNKSDSLVKNFGWPEAMFGDFNDFTTV 515

  Fly   379 DA---AYHSIL----LGRRSLYRNLEKLRKFQRTR---RLASHSAQQVRRYAQMFAPVNAFL--- 430
            ||   .|.||:    ..:..:|.....|:|....|   |:....|.:. .:.|..|.|||:.
 Worm   516 DAYNQDYASIIDLYTKDKNDIYGIFAVLKKGMEVREFFRIMGEPADRT-NFLQSPAMVNAWYQPE 579

  Fly   431 -------------GQHNLSTPLNYLLLGEFFSRSLVAAGSSSRTQG------------------- 463
                         ..:||:.|..|...|:      ...|....|.|
 Worm   580 RNSITFPYAAWNPPYYNLNYPQAYNFAGQ------GGTGGHELTHGYDDEGVQFGFNGELTDCSW 638

  Fly   464 ---AWRSSDSERRFAIFQQCVGKQ-------------------TNAIDLLLSLLAQRQALSAYGQ 506
               .|..::|...|....|||..|                   |...:.:..|..|:.|..:|.|
 Worm   639 NKCGWMDTNSSSGFIDMAQCVVTQFSTQCCPEKTGNIHCANGATTQGENIADLGGQQAAYRSYRQ 703

  Fly   507 WLATQAGLVERVDAVLAAGSSKMSLQRLFFVT----------------SLLVDCRSELGALQQDR 555
            ::||....||. |.:  .|....:..::|::|                .||.:..|.    .|.|
 Worm   704 YVATTRKGVEE-DRL--PGLENYTPNQIFWITYGYSWCMKQSDANLVHQLLTNPHSP----AQCR 761

  Fly   556 KRQVTHATLRNSPEFLEAFRCRPGDVLYPQDQ-RC 589
            ..||    :::.|||.:.|.|..|..:||:.. ||
 Worm   762 TNQV----MQDIPEFGKDFGCVRGSPMYPEPSGRC 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..590	CDD:472708	152/743 (20%)
nep-22	NP_509528.1	M13	83..793	CDD:341056	152/745 (20%)