DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl11 and nep-21

DIOPT Version :9

Sequence 1:	NP_649449.1	Gene:	Nepl11 / 40540	FlyBaseID:	FBgn0037230	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001360525.1	Gene:	nep-21 / 179925	WormBaseID:	WBGene00011794	Length:	864	Species:	Caenorhabditis elegans

Alignment Length:	742	Identity:	154/742 - (20%)
Similarity:	263/742 - (35%)	Gaps:	212/742 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 AYGQDDLLRVETELLSFSHNLEPYLDTSKQPCQDFYGYVCSH---SANL--------------SE 62
            |...:|::....|.:..:..|...|::...||:|||.:.|.:   :.||              |.
Worm   165 AKNHNDVVCTSRECVRLAGFLAENLNSKINPCEDFYEFACGNYGLNKNLPANKPLRHTISDVQSR 229

  Fly    63 TGRQRFQSLLKETDVAQLMDMELQLINFFKSC------ESGRGVEALKGSQLYRQSGGWPSLEPN 121
            ..:| .:|:|:....|.....:.....:::.|      || .||||::  .:.::.||||:||.:
Worm   230 LNKQ-VKSMLQSPISANEKPWDKVAKGYYQKCLDEEELES-TGVEAMR--DIAKRIGGWPTLEGD 290

  Fly   122 KVNASQRTNQTQRW-----------LGLLGYFHEVGAPYFFETSVTMQ-SNKRLVVLQPD----- 169
            |         .|.|           |.|.|    |.| ...|.:||.. ||....|::.|
Worm   291 K---------WQEWSHSWEEQIALVLNLTG----VNA-VILEMAVTHDPSNSSRSVIELDQPKWG 341

  Fly   170 ---------GTRRNTLRKFEQRVGEVLQSFGIEQSRAHVTALEVLSLER-----SRRDIVKADHV 220
                     |.....||.:...:.....:.|.:.:.|.....|.:..|.     |..|:|:.|..
Worm   342 AGSRYPYLSGANDPMLRNYTTLMKMTAVALGADPAIAEKEMNEAMEFELKLVNFSADDMVRRDPE 406

  Fly   221 EDQVQFSYGNFKRIV-FGNASLIRLDWDGYFR---KLLGGKTPQASDTIVVKQLPRLVEYFALLQ 281
            ....:|.....|.:. |       ::::.|.:   |.|...:|  :.|::|:::...|....:||
Worm   407 RGNNRFELWQLKSVFPF-------INFEKYLKTVFKELVALSP--NHTVIVREIDYFVGIQHVLQ 462

  Fly   282 NTSMVRLLNWI-WT--------DYLM-----------------------------DIVDADCHQL 308
            :|....|.|:| |.        ||..                             |..: ||..|
Worm   463 STPKRVLANYISWRLVQGGPTGDYFSFSPFLPPSAREPFYQFKANQTGMFNSPPPDRWE-DCVTL 526

  Fly   309 S----ETYAGDLYAHVVQRVTANRVELAQMYSELGKAYTDQLGGSVWIDEISRQSSRQFLGNIMH 369
            |    :...|.|:............::.::.|.|...:..||....|:|||:|:.:......|.:
Worm   527 SVIMMDMPVGRLFVENFFEKERAMKKMTELTSYLKNEFIKQLHVLDWMDEITRRRAISKANMIEY 591

  Fly   370 TT-----LNGDERLDAAYHSILLGRR---------SLYRNLEKLRKFQR--TRRLASHSAQQVRR 418
            .:     |..|..::..:..|:..|.         .|.|..|:|.:..:  .|.:...|..||..
Worm   592 KSGFPMVLFNDTWMEKNWGMIIKPREYLLHLTIRVKLVRFTEELLRLDQPLDRSMWFQSPAQVDA 656

  Fly   419 YAQMFAPVN------------AFLGQHNLSTPLNYL-------LLGEFFSRSLVAAGSSSRTQG- 463
            |   :||.|            .||   .|..| ||:       ::|...|.:....|......|
Worm   657 Y---YAPNNNEMIFPAGIMQFPFL---TLGVP-NYITYGMVGAVIGHEVSHAFDDQGGQYDEMGN 714

  Fly   464 --AWRSSDSERRFAIFQQCVGKQTNAIDLL---------LSL---LAQ----RQALSAYGQWLAT 510
              .|..:::|.:|....:|..:|...:.::         |||   :|.    :.|.:||..|.:.
Worm   715 LNDWWDAETEEKFIEKTRCFVRQYENVHVVEADIHLNGQLSLGENIADNGGVKTAFNAYKAWKSN 779

  Fly   511 QAGLVERVDAVLAAGSSKMSLQRLFFVT-----SLLVDCRSELGALQQDRKRQVTHA-------- 562
            ..|:.|..    ..|....:.|::||:.     ..||..:..:..:..|     .||
Worm   780 TTGISEPA----LPGFQNFTSQQMFFLAYANNWCSLVRPKHYIQIILTD-----VHAPSKYRAMI 835

  Fly   563 TLRNSPEFLEAFRCRPGDVLYPQDQRC 589
            .|:|.|||.:||:|..|..:.| :::|
Worm   836 PLQNRPEFAKAFQCPIGSPMNP-ERKC 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	148/710 (21%)
nep-21	NP_001360525.1	M13	193..862	CDD:341056	149/714 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910