Protein Alignment Nepl11 and nep-16

DIOPT Version :10

• Sequence 1: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Sequence 2: NP_001023203.2
• Gene: nep-16 / 177541
• WormBaseID: WBGene00018472
• Length: 868
• Species: Caenorhabditis elegans
• Alignment Length: 686
• Identity: 125/686 - (18%)
• Similarity: 226/686 - (32%)
• Gaps: 221/686 - (32%)

  Fly     1 MISKALAVLWIAGIAYGQDDLLRV----------ETELLSFSHNLEPYLDTSKQPCQDFYGYVCS 55
            ::|.||.::|:.     ..|..|.          ..:.:..:..|...:|...:||::||.|.|.
 Worm   207 LLSIALFLVWVI-----TTDGFRTIGAKSTNVCNTRQCIDIAFRLSSCIDDEIEPCENFYRYSCQ 266

  Fly    56 --HS----------ANLSETGRQRFQSLLKETDVAQLMDMELQLI-NFFKSCESGRGVEALKGSQ 107
              ||          :.|.:...:|..|||...:.::|:....:|. :.:.:|.:.    .|:.|.
 Worm   267 RYHSQTADKQMSFLSQLKDESLRRMHSLLSSEEDSRLLPKSARLSRSLYSACMNA----VLRSSN 327

  Fly   108 -------LYRQSGGWPSLEPNKVNASQRTNQTQRWLGLLGYFHEVGAPYFFETSVTMQSNKRLV- 164
                   ..|.....|.|...: |....:...:|..|:|.::........::..|..|...:::
 Worm   328 APTDLLTFIRNFPCGPLLRDCQ-NFHADSYSWERHAGMLDWYAGRYNLIVYDRDVHPQDRSKIIL 391

  Fly   165 -VLQPDGTRRNTLRKFEQRVGEVLQSFGIEQSRAHVTALEVLSLERSRRDIVKADHVEDQVQFSY 228
             :..||.|         ..||.:.:.. |:.:|...|..|.|.....|::::.|
 Worm   392 QIKPPDLT---------PIVGLIERDL-IDLARPSPTEFEPLLQLSLRQNLLSA----------- 435

  Fly   229 GNFKRIVFGNASLIRLDWDGYFRKLLGGKTPQASDTIVVKQLPRLVE-----YFALLQNTSMVRL 288
                   |...||:|...|                  |..||..:..     |.:..|:.|:...
 Worm   436 -------FARDSLLRDPRD------------------VQSQLDEVARLMVDLYISARQSASLTPN 475

  Fly   289 LNWIWTD---------YLMDIVDADCHQLSETY------------------AGDLYAHVVQRVTA 326
            ..::...         ||.:.:||   |||.||                  ..|:.|...::..|
 Worm   476 TTYMTIGEMFQALPQLYLREFLDA---QLSNTYRWTETDMLSIQDYDYFARLSDIMAQTSRQAVA 537

  Fly   327 NRVELAQMYSELGKAYT--DQLGGSVWIDEISRQSSRQFLGNIMHTTLNGDERLDAAYHSILLGR 389
            |.:....:::....:|:  ||.|....:|:||...    :|..|:        :|.|..:|
 Worm   538 NYLLTVTVWNLKQYSYSPRDQYGWRECVDQISSFE----IGRKMY--------VDKASQTI---- 586

  Fly   390 RSLYRNLEKLRKFQRTRRLASHSAQQVRRYAQMFAPVNAFLGQHNLSTPLNYL----LLGEF--F 448
                 :|.|:::|.:..::                   .||..|. ||||.||    .||.:  |
 Worm   587 -----DLPKIQEFLQNLKI-------------------DFLSVHR-STPLQYLSNINRLGFYVGF 626

  Fly   449 SR------------------------SLVAAGSSSRTQ-----GAWRSSDSERRFAIFQQCVGKQ 484
            .|                        |::..|.:.|..     |.:..:|....|.|....:...
 Worm   627 PRRLQNEELIWKPVSQVSLNETDYFDSMIRVGKAERDYTMSQIGTYLDNDDTTTFPISDPTMLYN 691

  Fly   485 TN--AIDLLLSLL-----AQRQALSAYGQWLATQAGLVERVDAVLAAGSSKMSLQRLFFVTSLLV 542
            :|  ||.:.|:.:     .....:..||.:.:.....::.:..|...|..|.|          .:
 Worm   692 SNVGAIVIPLAFIEPPIYLPGDEVPMYGIYSSLGITTLQMISKVFWQGLDKTS----------QL 746

  Fly   543 DCRSEL--GALQQDRKRQVT-HATLRNSPEFLEAFR 575
            :|...:  |.|..:|:|... ...|..:.|..:||:
 Worm   747 ECLDNVFRGFLDANRQRSPNIEPELLATIELADAFK 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..590	CDD:472708	117/632 (19%)
nep-16	NP_001023203.2	GluZincin	254..>725	CDD:472708	104/565 (18%)