DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl11 and nep-17

DIOPT Version :9

Sequence 1:	NP_649449.1	Gene:	Nepl11 / 40540	FlyBaseID:	FBgn0037230	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001254395.1	Gene:	nep-17 / 174996	WormBaseID:	WBGene00010070	Length:	1589	Species:	Caenorhabditis elegans

Alignment Length:	826	Identity:	164/826 - (19%)
Similarity:	248/826 - (30%)	Gaps:	308/826 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKALAVLWIAGIAYGQD--DLLRVETELLSFSHNLEPYLDTSKQPCQDFYGYVCSHSANLSETGR 65
            ||.|.|...|.::.|.|  :..:...:|...|.||      |..||.|||.|.|.:.     .|.
Worm    76 SKVLNVAQPAKVSPGTDKYNSYQQVVQLFKASVNL------SVDPCNDFYAYTCGNF-----KGD 129

  Fly    66 QRFQSLLKETDVAQLMDMELQLIN----------------FFKSCESGR---------GVEALKG 105
            ..|..    :|.:...||..:|.|                :|.:|.:.|         .|.....
Worm   130 MSFDI----SDNSNTNDMVTRLTNDTYISTAPLPVQQTRWYFDTCVNARQNWNTIADGSVVTAAI 190

  Fly   106 SQLYRQSGGWPSLEPNKVN-----ASQRTNQT---QRW-LG-LLGYFHEVGAPYFFETSVTMQSN 160
            :||   :.|.|....|...     ..|:|:.|   .|: || |.|.....|........|  .:|
Worm   191 NQL---AAGNPGKHENSTKFPFPMLDQKTDVTTFPDRFGLGYLTGSLTAQGVDTIISAGV--DTN 250

  Fly   161 KR---------LVVLQPDGTRRNT--LRKFE--------QRVGEVLQSFGIEQSRAHVTALEVLS 206
            .:         .::.||.....||  |:.|:        |....:||...::..     .|:...
Worm   251 WKDPAGPEGFAYLIDQPTTFAPNTYYLKDFDALNASLTYQITENMLQLAKVQNK-----TLDANI 310

  Fly   207 LERSRRDIVKADHV-------EDQVQ-----------------------FSYGNFKRIVFGNASL 241
            |.:..:||:|.|::       :|..:                       ||:..|..|..|.|..
Worm   311 LAKDVQDIIKLDYLLATKFSTDDTTRRQYDRSYNPNTLPQLLTQYHKDVFSWHMFLPIAVGTAEH 375

  Fly   242 IRLDWDGYFRKLLGGKTPQASDTIVVKQLPRLVEYFALLQNTSMVRLLNWIWTDYLMDI------ 300
            : ||      |||    .|.|.          ..|:..::.|.:..||..:..|..:.|
Worm   376 V-LD------KLL----DQGSG----------YNYYITMEPTKLNMLLTSLNKDNTLGITPRALV 419

  Fly   301 -------VDADCHQLSETYAGDLY--------------AHVVQRVTANRVELAQMYSELGKAYTD 344
                   ||:....|....||::.              .||:..   :|....::..:|.:|
Worm   420 NYFYYRLVDSLSEFLPAPPAGNMIRPFVKIERQPVGRPRHVLPE---DRKYERKLIEDLTEA--- 478

  Fly   345 QLGGSVWIDEISRQSSRQFLGNIMHTTL---NGDERLDAAYHSILLGRRSL-------------- 392
            |...:....:|...::|.|:..|..|..   |..|.:.....||::|.||:
Worm   479 QYSCAQETIDIQYANARLFIDQIYPTATDRKNVREHVAKVASSIVIGFRSMIDQLNWMTPSTKKG 543

  Fly   393 -YRNLEKLRK-----------FQRTRRLASHSAQQVRRYAQMFAPVNAFLGQHNLSTPLNYLLLG 445
             |..:|.|.|           .|.|...|..:..:...|..||..|..|    ||.:..:.|:.|
Worm   544 AYNKIENLVKNIAYPDWITDDAQLTAYHAPMNFTKTDTYVDMFFNVQNF----NLYSQWDQLVQG 604

  Fly   446 -------------------------------------EF-------FSRSLVAAG---------- 456
                                                 :|       |....|.||
Worm   605 PADRTGFNGPPGITNAWYQPELNSITFPAGILKKPFYDFNWPASVNFGAMGVIAGHELTHGFDDQ 669

  Fly   457 ----SSSRTQGAWRSSDSERRFAIFQQCV----------------------GKQT---NAID--- 489
                :...|...|..:.|:..|....|||                      |.||   |..|
Worm   670 GVQWNGVGTLSGWMDATSKVSFTNMAQCVVNEYSGFCPLDKATYGSAACIDGAQTQGENIADNGG 734

  Fly   490 LLLSLLAQRQALSAYGQWLATQAGLVERVDAVLAAGSSK-MSLQRLFFVTSLLVDCRSELGALQQ 553
            :..:..|.:..:..||.            |.||.....: .:..:|||::...|.|:......|.
Worm   735 IHSAFRAYKNYVDLYGP------------DPVLPDPQLQYFNPDQLFFLSFAQVWCQMPYTDAQF 787

  Fly   554 DRKRQV-THA--------TLRNSPEFLEAFRCRPGDVLYPQDQRCN 590
            .|:..| .|:        |::|.|.|..||.| |... |..|..||
Worm   788 LRQILVDVHSPSIYRVLGTIQNFPAFKTAFNC-PSST-YAPDNHCN 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	150/779 (19%)
nep-17	NP_001254395.1	PepO	108..833	CDD:226118	155/794 (20%)
		M13	112..830	CDD:189000	150/781 (19%)
		PepO	880..1583	CDD:226118
		M13	884..1581	CDD:189000
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910