Protein Alignment Nepl11 and nep-1

DIOPT Version :10

• Sequence 1: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Sequence 2: NP_496490.2
• Gene: nep-1 / 174787
• WormBaseID: WBGene00013926
• Length: 754
• Species: Caenorhabditis elegans
• Alignment Length: 732
• Identity: 152/732 - (20%)
• Similarity: 241/732 - (32%)
• Gaps: 227/732 - (31%)

  Fly    32 SHNLEPYLDTSKQPCQDFYGYVC-----SHSANLSETGRQRF----QSLLKE--------TDVAQ 79
            |..|:..|:.|..||.||:.|.|     ||......|...:|    :.:|.|        |.:..
 Worm    73 SRLLQKSLNLSLDPCDDFFEYACRAWVDSHPIPDDLTSYSQFTATREKVLAEMRKLYEDNTSIPT 137

  Fly    80 LMDMEL--QLINFFKSCESGRGVEALKGSQLYRQSGGWPSLEPNKVN------------------ 124
            ...:.|  |:.|.....|....|.|....:..:..|.||.:...|..
 Worm   138 SKSIALIKQIYNTCMDTEKHNAVGARDLLEKIKTYGYWPMVHNEKWRESTFDLTKLLSNTIQSRD 202

  Fly   125 ---------ASQRTNQTQRWL----GLLGYFHEVGAPYFFETSVTMQSNKRLVVLQPDGTRRNTL 176
                     |....|.::|.|    |.||..:.....|..|.....|..         ..|:.|:
 Worm   203 VSVFFDFGPAEDSRNVSRRLLSFDQGSLGLGYSTRDYYLDEKKYEKQMK---------AYRKYTI 258

  Fly   177 ---RKFEQRVGEVLQSFGIEQSRAHVTALE-----VLSLERSRRDIVKADHVEDQVQFSYGNFKR 233
               |.:.:..|..:....||.....:.|.|     :|..|..||:..|..:|.     .:.:.|.
 Worm   259 GKVRYYTEDAGMAVNESKIESDVDEIIAFEKEWAQILVAEEDRRNYTKLYNVR-----RFDDLKE 318

  Fly   234 IVFGNASLIRLDWDGYFRKLLGGKTP-------QASDTIVVKQLPRLVEYFALLQNTSMVRLLNW 291
            .:    |:|  ||    :||....||       :.:.:|::..:..|.:...|||||....:.|:
 Worm   319 YM----SII--DW----KKLTLSTTPFLVHSYLKTNPSIIISDVEYLQKMNTLLQNTDPRIVTNY 373

  Fly   292 I-------WTDYL-------------------------MDIVDADCHQLSETYA-GDLYAHVVQR 323
            |       |:..:                         .|.|.:...:||  || |.:|......
 Worm   374 ILLRWAGSWSQEIGKKYEDLQQEFAFQMYGRKQRQPRWKDCVSSAGGKLS--YASGSMYVRKYFD 436

  Fly   324 VTANRVELAQMYSELGKAYTDQLGGSVWID----EISRQSSRQFLGNIMHT--TLNGDERLDAAY 382
            ..|....| .|.::|.:|:.:.:..:.|:|    :.:.:.:.|.|..|.:.  .|| ||:||..|
 Worm   437 ANAKNTTL-DMITDLQEAFRNMMHANDWMDAETKKYALEKADQMLKQIGYPDFILN-DEKLDDWY 499

  Fly   383 HSI---------------LLGRRSLY--RNLEKLRKFQRTRRLASHSAQQVRRYAQMFAPVNAFL 430
            ..:               :..|.:.|  |.||.:.:|:               :....|.||||.
 Worm   500 KGLEGAPEDSFSQLVEKSIQWRNNFYYRRLLEPVNRFE---------------FISSAAVVNAFY 549

  Fly   431 G--QHNLSTP----------------LNY----LLLGEFFSRSLVAAGSSSRTQGAWR------- 466
            .  ::.::.|                |||    .::|...:......|......|..|
 Worm   550 SPTRNAIAFPAGILQQPFFDARFPKALNYGGIGAVIGHEITHGFDDTGRQFDNVGNLRDWWDNTT 614

  Fly   467 -SSDSERRFAIFQQCVGKQTNAIDLLLS-LLAQ----------RQALSAYGQWLATQAGLVERVD 519
             |..:||...|.:|....:....||.:: .|.|          :||..||..:|....|...|:.
 Worm   615 SSKFNERTQCIIEQYADVKLRGTDLRINGKLTQGENIADNGGIKQAFKAYKSYLEKHGGQEARLP 679

  Fly   520 AVLAAGSSKMSLQRLFFVTSLLVDCRSELGALQQDRKRQV------------THATLRNSPEFLE 572
            ..     ..::.::||||....|.|    ||...:.|..:            .:..|.|.|||.|
 Worm   680 QF-----ESLTNEQLFFVGYAQVWC----GAKTPETKTLLLLTDPHSPETARVNTVLTNQPEFAE 735

  Fly   573 AFRCRPGDVLYPQDQRC 589
            ||:|..|..:.| .:||
 Worm   736 AFKCPAGSPMNP-TKRC 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..590	CDD:472708	148/719 (21%)
nep-1	NP_496490.2	M13	85..751	CDD:341056	146/718 (20%)