Protein Alignment Nepl11 and nep-12

DIOPT Version :9

• Sequence 1: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Sequence 2: NP_001364537.1
• Gene: nep-12 / 173824
• WormBaseID: WBGene00017842
• Length: 832
• Species: Caenorhabditis elegans
• Alignment Length: 728
• Identity: 138/728 - (18%)
• Similarity: 248/728 - (34%)
• Gaps: 201/728 - (27%)

  Fly    14 IAYGQDDLLRVETELLSFSHNLEPYLDTSKQPCQDFYGYVCSHSAN-------------LSETGR 65
            :.||.|:...:..|.:..:.:....::....||:|||.:.|...|.             |||..:
 Worm   142 VNYGSDNSTCLTPECIRLAASYLNNMNRDANPCEDFYEFACGKYATRKVIAEHEKKVTVLSEMKK 206

  Fly    66 Q---RFQSLLKETDVAQ-LMDMELQLINFFKSC-----ESGRGVEALKGSQLYRQSGGWPSLEPN 121
            :   ..:.:|::|.... ...|:|..| :|.||     :...||:.|  ..:....||||.|
 Worm   207 EMDRHLKDILEKTSRENTTRSMKLAQI-YFDSCMDEFSQDDLGVQPL--MSMISNLGGWPLL--- 265

  Fly   122 KVNASQRTNQTQRWLGLLGYFHEVGAPYFFETSVTM---QSNKRLVVLQP------------DGT 171
             .||...:...| |..|.|:....|....|...|..   .|:|.:::..|            :..
 Worm   266 -TNARFDSIDFQ-WEVLAGHLALYGVDGIFRVFVHSSFDDSDKNVLMFSPPKLFLEKKKFYREVP 328

  Fly   172 RRNT-LRKFEQRVGEVLQSFGIE-QSRAHVTALEV---LSLERSRRDIVKAD----HVEDQVQFS 227
            ..|. |:.:.|.:..:|...|:: :....|...:|   :..||...::.:.:    |.......:
 Worm   329 SSNVYLQYYRQYILSLLSLLGVDMEDETGVIEYQVDDIIDFERRIANLTRIELSRNHSSINNMIT 393

  Fly   228 YGNFKRIVFGNASLIRLDWDGYFRKLLGGKTPQASDTIVVKQLPRLVEYF----ALLQNTSMVRL 288
            :|.|||      ...:::||.:|.:.:.|...:..|::|:..:.  |.||    :|:::..:..:
 Worm   394 FGEFKR------KYDKINWDAFFNEEMRGNLGRMPDSLVINVVD--VNYFDNLYSLIKSKPLSSI 450

  Fly   289 LNWI-W---TDY-----------LMDI------VDAD------C-HQLSETYAGDLYAHVVQRVT 325
            .|:: |   ::|           ::|.      |.:|      | .::.|..|..|.....|:..
 Worm   451 NNFLMWCLVSNYDMYLPAKYRKPMLDFRQKMYGVSSDDPLWEVCVGEVRENLAMPLSTEYAQKFF 515

  Fly   326 ANRVELA--QMYSELGKAYTDQLGGSVWIDEISRQSSRQFLGNIMHTTLNGDERLDAA-----YH 383
            ..:.:|.  .|..:|.||....|..:.||||.:|:::...|..:.|.....|..|:..     |.
 Worm   516 TKKDKLVAEDMIRDLKKAMEQTLLNADWIDESTREAALMKLDAMGHKIGFPDSLLNETAVLLPYA 580

  Fly   384 SILLGRRSLYRNLEKLRKFQRTRRLAS-HSAQQVRRYAQMFAPVNAF-------------LGQHN 434
            .:.|.....:.|...|:|......|:. |....:..:|.....|:||             :.|..
 Worm   581 GVRLTANQYFDNAISLKKAAYRDALSKLHRTPSLIDWASPIIAVDAFHYFTGNEIIFPAGILQFP 645

  Fly   435 LSTP-----LNYLLLGEFFSRSLVAA----GSSSRTQG---AWRSSDSERRFAIFQQCVGKQTNA 487
            :..|     .||..:|......:...    |:....:|   .|..:::...|...:||
 Worm   646 MFVPDAPAFSNYGAIGMGIGHEITHGYDDLGAQYDDKGNLRGWWHTETMTTFQKKKQC------- 703

  Fly   488 IDLLLSLLAQRQALSAYGQWLATQAGLVERVDAVLAAGS-------------------------- 526
                  .:||      ||..:..|.|  .:||..:..|.
 Worm   704 ------FVAQ------YGSKIEPQTG--RKVDGKMTIGENIADNGGLRVAFQAYQLRSDREKETR 754

  Fly   527 -----SKMSLQRLFFVTSLLVDCRS---------------ELGALQQDRKRQVTHATLRNSPEFL 571
                 :..|..:|||:......|.:               .||..:       .:..|:|.|.|.
 Worm   755 RLPGLTDFSPNQLFFLAYANTWCEALKPSAIDHIMDTDVHSLGMFR-------VNVPLQNLPAFS 812

  Fly   572 EAFRCRPGDVLYP 584
            :.|.|..|..:.|
 Worm   813 KEFDCPIGSPMNP 825

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	134/697 (19%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	134/699 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770