DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl11 and nep-10

DIOPT Version :9

Sequence 1:	NP_649449.1	Gene:	Nepl11 / 40540	FlyBaseID:	FBgn0037230	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_494532.2	Gene:	nep-10 / 173684	WormBaseID:	WBGene00017555	Length:	711	Species:	Caenorhabditis elegans

Alignment Length:	736	Identity:	142/736 - (19%)
Similarity:	240/736 - (32%)	Gaps:	281/736 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ELLSFSHNLEPYLDTSKQPCQDFYGYVC----SHSA---NLSETGRQRFQSLLKE---TDVAQLM 81
            |.::.:|.|..|.|.|..||||||.:.|    .|||   ....|.|.....|::|   .:.....
Worm    81 ECITLAHELHNYKDPSVDPCQDFYQHFCGKFYEHSAIGQGRMATKRSTLSKLIREFLLKNKTSTS 145

  Fly    82 DMELQLINFFKSCESGRGVEALKGSQL--------------YRQSGGWPSLEP----NKVNASQR 128
            ..|..:...:..|.     |..|.|.|              .::.|.||.|:.    :|.|.::.
Worm   146 KSENTMKQVYAKCR-----ELQKISDLNSIPPQALLDIFSDIKKIGAWPVLDKDWDGSKFNLNEM 205

  Fly   129 TNQTQRWLG--LLGYFH--EVGAPYFFETSVTMQSNKRLVVLQPDGTRRNTLRKFEQRVGEVLQS 189
            ..|... ||  .||:||  .:..||              |:::|      .|::
Worm   206 LRQLVN-LGETHLGFFHFDFIARPY--------------VLIKP------PLKQ----------- 238

  Fly   190 FGIEQSRAHVTALEVLSLERSRRDIVKADHVEDQVQFSYGNFKRIVFGNASLIRLDWDGYF---R 251
             |:::|          .||:..:.|::|:.::....||.                |.|.||   .
Worm   239 -GVQKS----------VLEKVVKMILEANEIKMDQGFSE----------------DLDEYFELSN 276

  Fly   252 KLLGGKTPQASDTIV---------------VKQLPR-------------LVEYF----------- 277
            ::...|.|:.|.:||               ::.:||             :|.|.
Worm   277 RIKIDKLPRTSRSIVGLLPDVRRINFRGLILEMMPRSKMNRFLGTLFQKVVTYHHPLFVRDNETN 341

  Fly   278 ---ALLQNTSMVRLLNWIWTDYLMDIV---------DAD-CHQLSETYAGDLYAHVVQRV----- 324
               .::::||...|.|::..:::...:         |.: |.::           |||.:
Worm   342 HLDTIIRSTSNRALANYLIFNFIHSSIKFLTFGLKSDRERCEKI-----------VVQELPRPSL 395

  Fly   325 ---------TANRVELAQMYSELGKAYTDQLGGSVWIDEISRQSSRQFLGNIMHTTLNGDE---- 376
                     ..||.|:|::        |:.:..:|.  |:.|:|. .|..::....|...|
Worm   396 RVFMRNCVDKGNREEVAKL--------TETVKENVL--EMIRESD-SFTPSVKKRVLKKVEAIGA 449

  Fly   377 ------------RLDAAYHSILL-GRRSLYRNLEKLRKFQRTRRLASHSAQQVRRYAQMFAPVNA 428
                        .||..|.::.| ...|.|:..:||.:.:...::...:.|.....:.....|||
Worm   450 IIGYPDHFDPPGTLDKEYENLTLDASDSYYKMSQKLHQLRLQHQMEFLAGQTPLSPSDQVLEVNA 514

  Fly   429 -FLGQHNLSTPLNYLLLGEFFSR------SLVAAG-------------SSSRTQGAWRSSDSERR 473
             :..:.|..|.|...|...||..      :|:..|             ...|..| |..::....
Worm   515 HYDSKDNALTVLAPFLDDPFFDSTYPEYVNLIFTGFLIGHEFGHSIDPKILRRDG-WYKTEDMTE 578

  Fly   474 FAIFQQCV------------GKQTNAIDLLLSLLAQRQALSAYGQWLATQA--GLVERVDAVLAA 524
            :....||:            |||.|....:..::         |.|:....  ...:::|.
Worm   579 YGKRAQCLIDQYDNYDDPDHGKQMNGTYCIGEIV---------GDWVGRDVTWRAFKKMDL---- 630

  Fly   525 GSSKM---------SLQRLFFVTSLLVDC--RS--ELGALQQDRKRQVTHAT--------LRNSP 568
              |||         :|.:|:|....|..|  ||  .|..|..|     .|.|        ..|.|
Worm   631 --SKMQKLIGFEDKNLDQLYFRIQSLFFCGPRSMKSLEQLLSD-----PHPTEVFRVNGIYSNMP 688

  Fly   569 EFLEAFRCRPGDVLYPQDQRC 589
            :|.:||.|..|..:.| :::|
Worm   689 QFAKAFNCPIGSPMNP-EKKC 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	135/716 (19%)
nep-10	NP_494532.2	M13	97..709	CDD:189000	136/720 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810