Protein Alignment Nepl11 and nep-10

DIOPT Version :10

• Sequence 1: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Sequence 2: NP_494532.2
• Gene: nep-10 / 173684
• WormBaseID: WBGene00017555
• Length: 711
• Species: Caenorhabditis elegans
• Alignment Length: 736
• Identity: 142/736 - (19%)
• Similarity: 240/736 - (32%)
• Gaps: 281/736 - (38%)

  Fly    27 ELLSFSHNLEPYLDTSKQPCQDFYGYVC----SHSA---NLSETGRQRFQSLLKE---TDVAQLM 81
            |.::.:|.|..|.|.|..||||||.:.|    .|||   ....|.|.....|::|   .:.....
 Worm    81 ECITLAHELHNYKDPSVDPCQDFYQHFCGKFYEHSAIGQGRMATKRSTLSKLIREFLLKNKTSTS 145

  Fly    82 DMELQLINFFKSCESGRGVEALKGSQL--------------YRQSGGWPSLEP----NKVNASQR 128
            ..|..:...:..|.     |..|.|.|              .::.|.||.|:.    :|.|.::.
 Worm   146 KSENTMKQVYAKCR-----ELQKISDLNSIPPQALLDIFSDIKKIGAWPVLDKDWDGSKFNLNEM 205

  Fly   129 TNQTQRWLG--LLGYFH--EVGAPYFFETSVTMQSNKRLVVLQPDGTRRNTLRKFEQRVGEVLQS 189
            ..|... ||  .||:||  .:..||              |:::|      .|::
 Worm   206 LRQLVN-LGETHLGFFHFDFIARPY--------------VLIKP------PLKQ----------- 238

  Fly   190 FGIEQSRAHVTALEVLSLERSRRDIVKADHVEDQVQFSYGNFKRIVFGNASLIRLDWDGYF---R 251
             |:::|          .||:..:.|::|:.::....||.                |.|.||   .
 Worm   239 -GVQKS----------VLEKVVKMILEANEIKMDQGFSE----------------DLDEYFELSN 276

  Fly   252 KLLGGKTPQASDTIV---------------VKQLPR-------------LVEYF----------- 277
            ::...|.|:.|.:||               ::.:||             :|.|.
 Worm   277 RIKIDKLPRTSRSIVGLLPDVRRINFRGLILEMMPRSKMNRFLGTLFQKVVTYHHPLFVRDNETN 341

  Fly   278 ---ALLQNTSMVRLLNWIWTDYLMDIV---------DAD-CHQLSETYAGDLYAHVVQRV----- 324
               .::::||...|.|::..:::...:         |.: |.::           |||.:
 Worm   342 HLDTIIRSTSNRALANYLIFNFIHSSIKFLTFGLKSDRERCEKI-----------VVQELPRPSL 395

  Fly   325 ---------TANRVELAQMYSELGKAYTDQLGGSVWIDEISRQSSRQFLGNIMHTTLNGDE---- 376
                     ..||.|:|::        |:.:..:|.  |:.|:|. .|..::....|...|
 Worm   396 RVFMRNCVDKGNREEVAKL--------TETVKENVL--EMIRESD-SFTPSVKKRVLKKVEAIGA 449

  Fly   377 ------------RLDAAYHSILL-GRRSLYRNLEKLRKFQRTRRLASHSAQQVRRYAQMFAPVNA 428
                        .||..|.::.| ...|.|:..:||.:.:...::...:.|.....:.....|||
 Worm   450 IIGYPDHFDPPGTLDKEYENLTLDASDSYYKMSQKLHQLRLQHQMEFLAGQTPLSPSDQVLEVNA 514

  Fly   429 -FLGQHNLSTPLNYLLLGEFFSR------SLVAAG-------------SSSRTQGAWRSSDSERR 473
             :..:.|..|.|...|...||..      :|:..|             ...|..| |..::....
 Worm   515 HYDSKDNALTVLAPFLDDPFFDSTYPEYVNLIFTGFLIGHEFGHSIDPKILRRDG-WYKTEDMTE 578

  Fly   474 FAIFQQCV------------GKQTNAIDLLLSLLAQRQALSAYGQWLATQA--GLVERVDAVLAA 524
            :....||:            |||.|....:..::         |.|:....  ...:::|.
 Worm   579 YGKRAQCLIDQYDNYDDPDHGKQMNGTYCIGEIV---------GDWVGRDVTWRAFKKMDL---- 630

  Fly   525 GSSKM---------SLQRLFFVTSLLVDC--RS--ELGALQQDRKRQVTHAT--------LRNSP 568
              |||         :|.:|:|....|..|  ||  .|..|..|     .|.|        ..|.|
 Worm   631 --SKMQKLIGFEDKNLDQLYFRIQSLFFCGPRSMKSLEQLLSD-----PHPTEVFRVNGIYSNMP 688

  Fly   569 EFLEAFRCRPGDVLYPQDQRC 589
            :|.:||.|..|..:.| :::|
 Worm   689 QFAKAFNCPIGSPMNP-EKKC 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..590	CDD:472708	136/718 (19%)
nep-10	NP_494532.2	M13	97..709	CDD:341056	136/720 (19%)