DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl11 and Ecel1

DIOPT Version :9

Sequence 1:	NP_649449.1	Gene:	Nepl11 / 40540	FlyBaseID:	FBgn0037230	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001264854.1	Gene:	Ecel1 / 13599	MGIID:	1343461	Length:	775	Species:	Mus musculus

Alignment Length:	717	Identity:	147/717 - (20%)
Similarity:	248/717 - (34%)	Gaps:	219/717 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LEPYLDTSKQPCQDFYGYVCS-----HS-----------ANLSETGRQRFQSLLKETDVAQLMDM 83
            |...||.|..||||||.:.|.     |:           |.:.|...:|.:.||...........
Mouse   113 LSANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRLLARPTGGPGGAA 177

  Fly    84 ELQLINFFKSCESGRGVEALKGS---QLYRQSGGWPSLEPNKVNASQRTNQTQRW-LGLLGY--- 141
            :.::..||:||...|.:|.|...   ::....|||     :...|:.|.. ..|| |..|.|
Mouse   178 QRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGW-----DLGGAADRPG-AARWDLNRLLYKAQ 236

  Fly   142 -FHEVGAPYFFETSVTMQSNKRLVV-LQPDGTR--RNTL---------------RKFEQRVGEVL 187
             .:...|.:....|:..:::.|.|: :..||..  ..||               |.|.||:..:|
Mouse   237 GVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEESEKILAAYRVFMQRLLRLL 301

  Fly   188 QSFGIEQSRAHVTALEVLSLERS------------RRDIVKADHVEDQVQFSYGNFKRIVFGNAS 240
            .:..:||.     |.|:|.||:.            |||:..|             :.::..|...
Mouse   302 GADAVEQK-----AQEILQLEQRLANISVSEYDDLRRDVSSA-------------YNKVTLGQLQ 348

  Fly   241 LI--RLDW----DGYFRKLLGGKTPQASDTIVVKQLPRLVEYFALLQNTSMVRLLNW-IW----- 293
            .|  .|.|    |..|::..     ...:.:|:.....:.:...|:::|....|.|: :|
Mouse   349 KIIPHLQWKWLLDQIFQEDF-----SEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVV 408

  Fly   294 -TDYLMDIVDADCHQLSETYAGDLYAHVVQRV---TANR--------VELAQMYSELGKAYTDQL 346
             :::|........|:|::...|:.....:.||   .|||        :.:.:.:|...||...||
Mouse   409 LSEHLSSPFREALHELAKEMEGNDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQL 473

  Fly   347 GGSV------------WIDEISRQSSRQFLGNIMHTT-----LNGDERLDAAYH----------S 384
            ...:            |:|..::.::|..|..:|...     |...|.:|..|.          :
Mouse   474 VEDIKYILGQRLEELDWMDAQTKAAARAKLQYMMVMVGYPDFLLKPEAVDKEYEFEVHEKTYFKN 538

  Fly   385 ILLG-RRSLYRNLEKLRKFQRTRRLASHSAQQVRRYAQMFAP--VNAF-------------LGQH 433
            ||.. |.|:..:::|:|             |:|.:.:.:..|  :||:             :.|.
Mouse   539 ILNSIRFSIQLSVKKIR-------------QEVDKSSWLLPPQALNAYYLPNKNQMVFPAGILQP 590

  Fly   434 NLSTP-----LNYLLLGEFFSRSLVA-----AGSSSRTQGA--WRSSDSERRFAIFQQCV----- 481
            .|..|     |||..:|......|..     .|...|:...  |.:..|...|....:|:
Mouse   591 TLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTETSYSHFLRKAECIVRLYD 655

  Fly   482 ----------GKQT---NAIDLLLSLLAQRQALSAYGQWLATQAGLVERVDAVLAAGSSKMSLQR 533
                      ||.|   |..|    :...:.|..||.:|: .:.|....:..:      |.:..:
Mouse   656 NFTVYNQRVNGKHTLGENIAD----MGGLKLAYYAYQKWV-REHGPEHPLHRL------KYTHNQ 709

  Fly   534 LFFVT---SLLVDCRSELGALQ--QDRKRQVTHATLRNSPEFLE---AFRCRPGDVLYPQDQRCN 590
            |||:.   :..:..||:...||  .|:.....:..|.:..:|.|   ||.|       |:|...|
Mouse   710 LFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHC-------PKDSPMN 767

  Fly   591 PL 592
            |:
Mouse   768 PV 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	141/702 (20%)
Ecel1	NP_001264854.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..52
Ecel1	NP_001264854.1	M13	121..773	CDD:341056	143/709 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900