Protein Alignment Nepl11 and Nep5

DIOPT Version :10

• Sequence 1: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Sequence 2: XP_061503273.1
• Gene: Nep5 / 1273520
• VectorBaseID: AGAMI1_014349
• Length: 834
• Species: Anopheles gambiae
• Alignment Length: 806
• Identity: 154/806 - (19%)
• Similarity: 258/806 - (32%)
• Gaps: 266/806 - (33%)

  Fly     6 LAVLWIAGIAYGQDDLLRVETELLSFSHNLEPYLDTSKQPCQDFYGYVCSH-------------- 56
            :|::.||.:.:...::.. ..:.|..:..|:..:|.:..||:|||.|.|.:
Mosquito    70 IAIIVIACLLHFPPEICH-SADCLRSAAALKHSMDLTVDPCEDFYQYACGNWEDEHPRPDTYVSF 133

  Fly    57 ------SANLSETGRQRFQ---SLLKETDVAQLMDMELQLINFFKSCESGRG--VEALKGSQLYR 110
                  .|.:....|...|   |.|....|.|...|....:|.......|.|  .:.||..||
Mosquito   134 DWFSERQAKILRNIRHYLQANSSALDPKPVVQARTMYAACLNLTAMDRLGYGPVFKYLKQFQL-- 196

  Fly   111 QSGGWPSLEPNKVNASQRTNQTQ--RWLGLLGYFHE-VGAPYFFETSV----TMQSNKRLVVLQP 168
              ..:|||.......:..|.|..  .|:..|....: :|...|....|    ..:...|||:..|
Mosquito   197 --PPYPSLLNVTEGPASATFQGYGFDWVKSLAKIKQLLGMDIFIGLDVYPDPRHRDYNRLVLGTP 259

  Fly   169 DG------------------TRRNTL-----------------------------RKFEQRVGEV 186
            :.                  |||..:                             :||...|.::
Mosquito   260 ESGSDLPFNTDILRHIRRGRTRRKLMVSADDEADGESDGEEVEDADDEVGPLTAYKKFMIGVMKL 324

  Fly   187 L----------QSFGIEQSRAHVTALE----VLSLERSRRDIVKADHVEDQVQFSYGNFKRIVF- 236
            |          :||..:..||....::    :....|...:..::.:|||::     |.:.||:
Mosquito   325 LVNSTDPTIKVESFNAQFERAATIVVQFSDSISKFNREAENASRSTNVEDRL-----NLQDIVYY 384

  Fly   237 --------GNASLIRLD----WDGYFRKLLGGKTPQA----SDTIVVKQ------LPRLVEYFAL 279
                    .:..|...|    |:.....:..| .|:|    .|.:::..      |..||:|.|:
Mosquito   385 TVADLQNITDTHLAPKDPLPIWERLLASVFEG-IPEAQLNLQDELILTSNADLLYLKLLVDYLAV 448

  Fly   280 LQNTSMVRLLNWIWT------------------DYLMDIVDAD--------CHQLSETYAGDLYA 318
            .. .:.:.|..| ||                  ||...|..:|        |........|...:
Mosquito   449 TP-LAHIELYIW-WTVVEELILHTTLEVRKLYYDYYKSIAPSDGFSSRTLYCTGTVNRLLGMAVS 511

  Fly   319 HVVQ-----RVTANRVELAQMYSELGKAYTDQLGGSVWIDEISRQSS-------RQFLGN---IM 368
            :.:.     |.|..||:  .|...:..|:...:..:.|:|..::||:       |..:|.   |:
Mosquito   512 YAISSDNFTRDTKPRVQ--DMLRYIRTAFEGLVRDTTWMDWPTKQSTLRKSQAMRSLIGFPDWIL 574

  Fly   369 HTTLNGDERLDAAYHSILLGRRSLY----------RNLEKLRKFQRTRRLASHSAQQVRRYAQMF 423
                  |.|....::|.|....|.:          :|:.|||::::...|:         :..:.
Mosquito   575 ------DHRELEQHYSGLQVNESTHLENMMQEVQRKNIIKLRRWRQKHELS---------WETLP 624

  Fly   424 APVNAF-LGQHNLST----------------PLNYLLLGEFFSRSLVAAGSSSRTQ-------GA 464
            ..|||| ..|.|..|                .|||..||......|......|..|       ..
Mosquito   625 TNVNAFHTFQENAITIPIAILQYPFYHLGLEALNYGALGTILGHELTHGFDDSGRQFDKDGNLAQ 689

  Fly   465 WRSSDSERRFAIFQQC---------VGKQTNAIDLLLSLLAQRQALSAYGQWLATQAGLVERVDA 520
            |.:..:.:.:....:|         :.:..:.||.||:|          |:.:|...|:.|...|
Mosquito   690 WWTDRTVQEYVNRTKCFVSQYSRYYIPEADDYIDGLLTL----------GENIADNGGVREAFRA 744

  Fly   521 V-----------LAAGSSKMSLQRLFFVTSLLVDCRSELGALQQD-----------RKRQVTHAT 563
            .           |..|....:.::|||::...:.|.|...|..:.           |.:.|
Mosquito   745 YQLYVKNGGKDPLLPGFEHYTHEQLFFISYGNIWCESHTQAAAKAYLDDSHCPGKFRLKGV---- 805

  Fly   564 LRNSPEFLEAFRCRPGDVLYPQDQRC 589
            |.|||||.:.|.|:||..:.|...:|
Mosquito   806 LTNSPEFSQTFGCKPGTEMNPGKDKC 831

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..590	CDD:472708	148/767 (19%)
Nep5	XP_061503273.1	None