DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nepl11 and EEF1AKMT4-ECE2

DIOPT Version :9

Sequence 1:NP_649449.1 Gene:Nepl11 / 40540 FlyBaseID:FBgn0037230 Length:592 Species:Drosophila melanogaster
Sequence 2:NP_055508.3 Gene:EEF1AKMT4-ECE2 / 110599583 HGNCID:53615 Length:883 Species:Homo sapiens


Alignment Length:731 Identity:157/731 - (21%)
Similarity:256/731 - (35%) Gaps:190/731 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LAVLWIAGIAYGQDD---------LLRVETELLSFSHNLEPYLDTSKQPCQDFYGYVCSH--SAN 59
            |..|...|:.|.:|.         .:||..::|.       .||....||:|||.:.|..  ..|
Human   193 LGCLVALGVQYHRDPSHSTCLTEACIRVAGKILE-------SLDRGVSPCEDFYQFSCGGWIRRN 250

  Fly    60 LSETGRQRFQS--------------LLKETDVAQLMDMELQLINFFKSCESGRGVEALKGSQ--- 107
            ....||.|:.:              ||:.|......:.|.:...|:.||.....:|.| |:|   
Human   251 PLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEEL-GAQPLR 314

  Fly   108 -LYRQSGGW----PSLEPNKVNASQRTNQTQRWLGLLGYFHEVGAPYF--FETSVTMQSNKRLVV 165
             |..:.|||    |..:.|.:...:....|.|           ..|:|  :.::.:..||..::.
Human   315 DLIEKIGGWNITGPWDQDNFMEVLKAVAGTYR-----------ATPFFTVYISADSKSSNSNVIQ 368

  Fly   166 LQPDG-------------TRRNTLRKFEQRVGEVLQSFGIEQSRAHVTALEVLSLERSRRDI-VK 216
            :...|             .....|..:...:.|:....|...:.......:||.||....:| |.
Human   369 VDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVP 433

  Fly   217 ADHVEDQVQFSYGNFKRIVFGNASLIRL-------DWDGYFRKLLGGKTPQASDTIVVKQLPRLV 274
            .|...|:.:         ::...|:..|       ||..:...||.......|:.:||..:..|.
Human   434 QDQRRDEEK---------IYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQ 489

  Fly   275 EYFALLQNTSMVRLLNW-IW------TDYLMDIVDADCHQLSETYAGDLYAHVVQ---------- 322
            :...|:..|....|.|: ||      |..|....::...:|.||..|...:.|.:          
Human   490 QVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDD 554

  Fly   323 -----------RVTANR--VELAQ-MYSELGKAYTDQLGGSVWIDEISRQSSRQFLGNIMHTTLN 373
                       :.|.:|  .|:|: |.||:..|:.:.||..||:||.:||::::....|......
Human   555 ALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGF 619

  Fly   374 GD-----ERLDAAYHSILLGRRSLYRNLEKLRKFQRTRRLASHSAQQVRR------YAQMFAPVN 427
            .|     :.||..|....:...|.::|:..|..|.     |...|.|:|:      ::.....||
Human   620 PDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFS-----AKVMADQLRKPPSRDQWSMTPQTVN 679

  Fly   428 A-FLGQHN--------LSTP---------LNY----LLLGEFFSRSLVAAGSSSRTQG---AWRS 467
            | :|...|        |..|         ||:    :::|...:.:....|.....:|   .|..
Human   680 AYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQ 744

  Fly   468 SDSERRFAIFQQCVGKQTNAIDLLLSLLAQRQAL--------------SAYGQWLATQAGLVERV 518
            ::|...|.....|:.:|.|...:....|..||.|              :||..|| .:.|..:::
Human   745 NESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWL-RKHGEEQQL 808

  Fly   519 DAVLAAGSSKMSLQRLFFVTSLLVDCRSELGALQQDRKRQVT--HA--------TLRNSPEFLEA 573
            .||      .::..:||||....|.|  .:...:...:..||  |:        ||.||.:||..
Human   809 PAV------GLTNHQLFFVGFAQVWC--SVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRH 865

  Fly   574 FRCRPGDVLYPQDQRC 589
            |.|..|..:.| .|.|
Human   866 FGCPVGSPMNP-GQLC 880

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nepl11NP_649449.1 GluZincin 45..589 CDD:301352 146/681 (21%)
EEF1AKMT4-ECE2NP_055508.3 Methyltransferase-like region. /evidence=ECO:0000305 1..160
Methyltransf_25 62..>128 CDD:316196
S-adenosyl-L-methionine binding. /evidence=ECO:0000250|UniProtKB:P0DPD7 88..89
S-adenosyl-L-methionine binding. /evidence=ECO:0000250|UniProtKB:P0DPD7 113..114
M13 232..881 CDD:189000 147/685 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG3590
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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