DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl11 and LOC100332538

DIOPT Version :9

Sequence 1:	NP_649449.1	Gene:	Nepl11 / 40540	FlyBaseID:	FBgn0037230	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_021322193.1	Gene:	LOC100332538 / 100332538	-ID:	-	Length:	808	Species:	Danio rerio

Alignment Length:	755	Identity:	140/755 - (18%)
Similarity:	266/755 - (35%)	Gaps:	211/755 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AVLWIAGI--------------AYGQDDLLRVE----TELLSFSHNLEPYLDTSKQPCQDFYGYV 53
            |:::.||:              |..||...|.:    ..||..:..::..:|.|.|||.|||.:.
Zfish    92 ALVFAAGMCVILGCMLALKFLXARSQDSQCRQDCVKRRSLLRAARFVQGNIDPSVQPCHDFYSFA 156

  Fly    54 CS-----HS-----------ANLSETGRQRFQSLLK-ETDVAQLMDMELQLINFFKSCESGRGVE 101
            |.     |.           ..:.|..:.:.|.||: .....:|...|.::..|::||.:.:.::
Zfish   157 CGGWLRRHGIPEDKLSYGIITAIGEQNQDKLQRLLQAPVQRRELESAERKVKEFYRSCINIKEID 221

  Fly   102 ALKG---SQLYRQSGGW-------------PSLEPNKVNASQRTNQTQRWLGLLGYFHEVGAPYF 150
            .|..   :::....|||             ....|.:.:.::...:||      |.:   ....|
Zfish   222 RLGAGPMTEVIDSCGGWDLSGAPPGGAGWDSGSAPIRPDFNEMLYKTQ------GVY---STSVF 277

  Fly   151 FETSVTM---QSNKRLVVLQPDG----TRRNTLRKFEQRVGEVLQSFGIEQSR------AHVTAL 202
            |..:|::   .|::..:.:..:|    .|...|.:.|..| ::|.|:.....|      ||...|
Zfish   278 FSLTVSVDDKNSSRNAIRIDQEGLTLPERTLYLGQDEDSV-KILASYKALMERLLSMLGAHNATL 341

  Fly   203 ---EVLSLERSRRDIVKADHVEDQVQFSYGNFKRIVFGNASLI--RLDWDGYFRKLLGGKTPQAS 262
               |:|.||....:|..::: |||.:.....:.||.......:  ...|.....::......:..
Zfish   342 KSREILDLETKLANITVSEY-EDQRKDISSMYNRITLKQLQKMAPSFHWKRLLDRIFNDNFSEEE 405

  Fly   263 DTIVVKQLPRLVEYFA----LLQNTSMVRLLNW-IW------TDYLMDIVDADCHQLSETYAGD- 315
            :.:|:     ..:|..    :::.||...|.|: :|      :::|.....:..|:.|....|.
Zfish   406 EIVVL-----ATDYMQTVSDIIKTTSKRVLHNYMLWRMVAALSEHLSTAFRSTIHEFSREIDGTE 465

  Fly   316 --------------------LYAHVVQR--VTANRVELAQMYSELGKAYTDQLGGSVWIDEISRQ 358
                                |.|..||:  .:::|.::.::..::..:...:|....|:||.::.
Zfish   466 QQLDLERLCLTQANKHFGMALGALFVQQHFSSSSRAKVQELVEDIKHSLDVRLQELDWMDEETKD 530

  Fly   359 SSRQFLGNIMHTT-----LNGDERLDAAY------------------HSILLGRRSLYRNLEKLR 400
            ::|..|.::|..|     |...|.:|..|                  ::|.|..:.:::.::|..
Zfish   531 AARGKLQHMMVMTGYPDFLLKPELIDEEYAFDVNEKTYFKNILNSIKYNIKLSIKKIHKEVDKTT 595

  Fly   401 KFQRTRRLASHSAQQVRRYAQMFAPVNAFLGQHNLSTP-----LNYLLLGEFFSRSLVAA----G 456
            .....:.|   :|..:....||..|  |.:.|..|..|     |||..:|......|...    |
Zfish   596 WLLPPQAL---NAYYLPNKNQMVFP--AGILQPTLYDPEFPQSLNYGGIGAIIGHELTHGYDDWG 655

  Fly   457 SSSRTQG---AWRSSDSERR--------------FAIFQQCVGKQTNAIDLLLSLLAQRQALSAY 504
            ......|   .|.:.:|.|:              |.::.|.|..:....:.:..|...:.:..||
Zfish   656 GQYDRYGNLKQWWTEESYRKFQKKTECIVKLYDNFTVYNQRVNGRLTLGENIADLGGLKLSYHAY 720

  Fly   505 GQWLATQA------GLVERVDAVLAAGSSKMSLQRLFFVTSLLVDC---RSELGALQ--QDRKRQ 558
            .:|:....      ||             |.:.::|||:......|   ||:...||  .|:
Zfish   721 QKWVREHGPERPLPGL-------------KHTHEQLFFIAFAQNWCMKRRSQSIYLQLLTDK--- 769

  Fly   559 VTHA--------TLRNSPEFLEAFRCRPGDVLYPQDQRCN 590
              ||        ::....||...|.|..|..:.|.: :|:
Zfish   770 --HAPEHYRVIGSVSQFEEFGRVFHCPRGSPMNPVN-KCS 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..589	CDD:301352	127/696 (18%)
LOC100332538	XP_021322193.1	M13	146..806	CDD:189000	128/699 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900