Protein Alignment Nepl11 and mmel1

DIOPT Version :10

• Sequence 1: NP_649449.1
• Gene: Nepl11 / 40540
• FlyBaseID: FBgn0037230
• Length: 592
• Species: Drosophila melanogaster
• Sequence 2: XP_012821551.1
• Gene: mmel1 / 100145721
• XenbaseID: XB-GENE-991673
• Length: 765
• Species: Xenopus tropicalis
• Alignment Length: 708
• Identity: 136/708 - (19%)
• Similarity: 252/708 - (35%)
• Gaps: 190/708 - (26%)

  Fly    34 NLEPYLDTSKQPCQDFYGYVCSHSAN---LSETG---------RQRFQSLLKETDVAQLMDME-- 84
            |::|.:    :||.|||.|.|....|   :.||.         |...:.:||  .:.::.|.|
 Frog    90 NMDPTI----EPCTDFYQYACGGWLNKHVIPETSSRYSIFDILRDEMEIILK--GLLEMPDQEDR 148

  Fly    85 -----LQLINFFKSCESGRGVE---ALKGSQLYRQSGGWPSLEPNKVNASQRTN-QTQRWLGLLG 140
                 .:::  :|||.:...:|   :|...:|....|.|| :.....|.::.:| ..:..|.||.
 Frog   149 DAFKKAKIL--YKSCMNESLIEQRDSLPLLELLTTVGEWP-VASTDWNGTKESNWSLEEKLSLLN 210

  Fly   141 Y-FHEVGAPYFFETSVTMQSNKRLVVL-QPD---GTRRNTLRKFE-QRVGEVLQSFGIEQSR--- 196
            | |::......|..:...:|:|.::.: ||.   .:|.....|.. ||:.|....|.|..:|
 Frog   211 YKFNKRVLVDIFVWNDDRESSKHIIYIDQPSLGMPSRDYYFNKGNYQRIREAYLQFMITIARMVR 275

  Fly   197 --AHVTALEVLSLERSRR------DIVKA---DHVEDQVQFSYGNFKRIVFGNA-SLIRLDWDGY 249
              .::|..:.|..|...|      ||.:|   ....:.|...|.....:.|... :|...:|..:
 Frog   276 EDRNLTRDDSLVQEEMTRVMDLETDIARATAPSEERNDVTLLYNKMTLLEFQQKFALDDFNWTSF 340

  Fly   250 FRKLLGGKT--PQASDTIVVKQLPRLVEYFALLQNTSMVRLLNWIWTDYLMDIVDA--------- 303
            .:.::....  .||.:.:||...|.|.:...:|.|.|...|.|::....::|.|.:
 Frog   341 IQGVMSSVNIQLQAEEEVVVYGAPYLHQLKNILSNYSASTLQNYVVWRMVIDRVSSLSRRYKDAR 405

  Fly   304 ------------------DC--------------HQLSETYAGDLYAHVVQRVTANRVELAQMYS 336
                              :|              ..:.||:||:           ::..::.:.:
 Frog   406 ASYRKALYGTTLEEARWRECVSYVNSNMENAVGAMYVKETFAGE-----------SKRMISDLIN 459

  Fly   337 ELGKAYTDQLGGSVWIDEISRQSSR-------QFLGNIMHTTLNGDERLDAAYHSILLGRRSLYR 394
            ::.:|:.:.|....|:||.|:..:|       :.:|...:...:.:::||....::.......:.
 Frog   460 KVREAFIETLDELQWMDETSKDKAREKALSIKEQIGYPDYILEDQNDKLDQETAALNFSEYQYFE 524

  Fly   395 N------------LEKLRK----------------FQRTRRLASHSAQQVRRYAQMFAPVNAFLG 431
            |            |:|||:                |....|      .|:...|.:..|  .|..
 Frog   525 NILEILNSGAQKSLKKLREPVDQDAWIIGAAVADAFYSPNR------NQIVFPAGILQP--PFFN 581

  Fly   432 QHNLSTPLNY----LLLGEFFSRSLVAAGSSSRTQG---AWRSSDSERRFAIFQQCV-------- 481
            :|. ...||:    :::|...:......|.:....|   .|.|:.|...|....:|:
 Frog   582 KHQ-PQALNFGGIGMVIGHEITHGFDDNGRNFDKDGNMFDWWSNFSAMHFKDQSRCMVYQYGNYT 645

  Fly   482 -----GKQTNAIDLLLSLLAQ----RQALSAYGQWLATQAGLVERVDAVLAAGSSKMSLQRLFFV 537
                 |:..:.|..|...:|.    |||..||.:|       |||...........::.::|||:
 Frog   646 WELAGGQNVSGIITLGENIADNGGVRQAYKAYLKW-------VERHGKEPKLPGLDLTYKQLFFL 703

  Fly   538 TSLLVDCRSELGALQQDRKRQVTHA--------TLRNSPEFLEAFRCRPGDVLYPQDQ 587
            ....|.|.|......:...:...|:        :|:|...|.|.|.|:.|..::|.::
 Frog   704 NFAQVWCGSYRPEYARHSIKTDVHSPFKYRVMGSLQNFEAFAEEFNCKKGTKMHPVEK 761

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl11	NP_649449.1	GluZincin	45..590	CDD:472708	134/697 (19%)
mmel1	XP_012821551.1	M13	95..763	CDD:341056	134/703 (19%)