DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LTBP3 and ltbp3

DIOPT Version :9

Sequence 1:	XP_011543334.1	Gene:	LTBP3 / 4054	HGNCID:	6716	Length:	1312	Species:	Homo sapiens
Sequence 2:	NP_001244070.1	Gene:	ltbp3 / 562912	ZFINID:	ZDB-GENE-060526-130	Length:	1258	Species:	Danio rerio

Alignment Length:	1366	Identity:	656/1366 - (48%)
Similarity:	814/1366 - (59%)	Gaps:	200/1366 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    26 LLLLLLLLLLGLGGRVEGGPAGERGAGGGGALARERFKVVFAPVICKRTCLKGQCRDSCQQGSNM 90
            ||:.|.|..|.|        .|||      |..|||||||.||:|||||||||||:|:|:||:|.
Zfish    10 LLIWLALPRLAL--------CGER------ASTRERFKVVIAPLICKRTCLKGQCQDTCEQGNNT 60

Human    91 TLIGENGHSTDTLTGSGFRVVVCPLPCMNGGQCSSRNQCLCPPDFTGRFCQVPAGGAGGGTGGSG 155
            |||||||.|.|||||.|||||||||.|||||.||:|..|||||.||||.||.|.
Zfish    61 TLIGENGQSADTLTGPGFRVVVCPLTCMNGGVCSTRTHCLCPPGFTGRLCQYPL----------- 114

Human   156 PGLSRTGALSTGALPPLAPEGDSVASKHAIYAVQVIADPPGP--------GEGPPAQ----HAAF 208
                ||.|              :..:|..:|.|||:   ||.        |.|...|    |:.|
Zfish   115 ----RTQA--------------TRGNKQPVYTVQVV---PGESQSLSESIGAGGRQQMTQTHSVF 158

Human   209 LVPLGPGQISAEALRPPRPPPVQAPPPVVNVRVHHPPEASVQVHRIESSNAESAAPSQHLLPHPK 273
            .:. |.|..|:|         ||     .||||.|.|:.||.:|.::.|..:         ||..
Zfish   159 TLQ-GTGHHSSE---------VQ-----FNVRVVHTPDTSVVIHPLDQSENK---------PHST 199

Human   274 PSHPR--PPTQKPLGRCFQDTLPKQPCGSNPLPGLTKQEDCCGSIGTAWGQSKCHKCPQLQYTGV 336
            .:..|  |.|.||.|||||:|.|||.|.||||||||.|||||||:|.:|||:||:|||.|.||
Zfish   200 KTVARLPPTTHKPKGRCFQETTPKQACSSNPLPGLTNQEDCCGSVGNSWGQNKCYKCPLLPYT-- 262

Human   337 QKPGPVRGEVGADCPQGYKRLNSTHCQDINECAMPGVCRHGDCLNNPGSYRCVCPPGHSLGPSRT 401
            :|...:..:..:.|||||||||||||||||||.|.|||.:|:|||..||:||.|.||:.| ..||
Zfish   263 EKHQAIVEDFASTCPQGYKRLNSTHCQDINECMMSGVCWNGECLNTRGSFRCTCKPGYVL-KERT 326

Human   402 QCIADKPEEKSLCFRLVSPEHQCQHPLTTRLTRQLCCCSVGKAWGARCQRCPTDGTAAFKEICPA 466
            :|:| ...|...|||:|:...:|:|.|:|||::::|||:||||||:.|:|||.||||:|.:||||
Zfish   327 RCVA-ATVELGYCFRMVTETGKCEHALSTRLSQEMCCCTVGKAWGSNCERCPQDGTASFNKICPA 390

Human   467 GKGYHILTSHQTLTIQGESDFSLFLHPDGPPKPQQLPESPSQAPPPEDTEEERGVTTDSPVSEER 531
            |||..:.|.|.|||.|........::||...||   ||.|.|...|...         ||:|
Zfish   391 GKGMSLQTYHGTLTFQPFLTSIEHINPDTEVKP---PEVPIQTTTPMHL---------SPIS--- 440

Human   532 SVQQSHPTATTTPARPYPELISRP-SPPTMRWFLPDLPPSRSAVEIAPTQVTETDECRLNQNICG 595
                     |..|.||.  ::::| :||.:.     :||...:.|::.|||:..|||:||.||||
Zfish   441 ---------THGPRRPV--IVAKPTTPPIVL-----VPPEADSHEVSQTQVSPMDECKLNSNICG 489

Human   596 HGECVPGPPDYSCHCNPGYRSHPQHRYCVDVNECEAEPCGPGRGICMNTGGSYNCHCNRGYRL-H 659
            ||.|......:.|||.||||||...:.|.|.|||:|:||  |||:|:|..|||.|:|:.|||| .
Zfish   490 HGVCANTQNGFMCHCYPGYRSHALTKRCEDENECDAQPC--GRGVCLNVLGSYKCNCHHGYRLSE 552

Human   660 VGAGGRSCVDLNECAKPHLCGDGGFCINFPGHYKCNCYPGYRLKASRPPVCEDIDECRDPSSCPD 724
            :.:|.|||.|:|||....:||.||.|||..|.|||.|.||:|.|..:||.||||:||.:|..||:
Zfish   553 ISSGKRSCSDINECLNTEICGVGGQCINQQGSYKCECLPGFRKKIQKPPHCEDINECLEPDICPN 617

Human   725 GKCENKPGSFKCIACQPGYRSQGGGACRDVNECAEGSPCSPGWCENLPGSFRCTCAQGYAPAPDG 789
            .:|||..||::|:.||||||:: .|.|.|::||.:...|..|.||||.||:||.|.:|:.|..:.
Zfish   618 EQCENTLGSYECLPCQPGYRAE-RGVCHDIDECKKHGVCLNGRCENLAGSYRCLCNEGFLPEANR 681

Human   790 RSCLDVDECEAGDVCDNGICSNTPGSFQCQCLSGYHLSRDRSHCEDIDECDFPAACIGGDCINTN 854
            :.|.|::||:...:|.||.|.||.|||:|||.:||..:::.||||||:||...|.|..|.||||.
Zfish   682 KGCRDINECQDNRLCANGHCINTDGSFRCQCYAGYQPTQEGSHCEDINECKRAANCQRGRCINTM 746

Human   855 GSYRCLCPQGHRLVGGRKCQDIDECSQDPSLCLPHGACKNLQGSYVCVCDEGFTPTQDQHGCEEV 919
            |||||.|.:|:.|..||.|:||:||..:.|||.|||.|:|.||.|||||::||..::|:|.||::
Zfish   747 GSYRCECQKGYTLENGRHCKDINECDGERSLCQPHGVCENRQGGYVCVCNDGFRLSEDKHSCEKI 811

Human   920 EQPHHKKECYLNFDDTVFCDSVLATNVTQQECCCSLGAGWGDHCEIYPCPVYSSAEFHSLCPDGK 984
            |.  .|||||||.|||||||||||||||:||||||:|.||||||||||||||.|||:|||||.|:
Zfish   812 ES--DKKECYLNLDDTVFCDSVLATNVTKQECCCSIGVGWGDHCEIYPCPVYRSAEYHSLCPIGR 874

Human   985 GYTQDNNIVNYGIPAHRDIDECMLFGSEICKEGKCVNTQPGYECYCKQGFYYDGNLLECVDVDEC 1049
            |:..|...:.||..||||||||:||.:||||||:|:|||||:||||:||||||.|||||:|||||
Zfish   875 GFYHDQEKIEYGFVAHRDIDECVLFSNEICKEGRCMNTQPGFECYCQQGFYYDSNLLECIDVDEC 939

Human  1050 LDESNCRNGVCENTRGGYRCACTPPAEYSPAQRQCLSPEEMDVDECQDPAACRPGRCVNLPGSYR 1114
            .|||.|.||.|.||||.:.|.|.||.......::|:.|..:.:|||||||.|:.|:|||...||.
Zfish   940 HDESLCINGHCVNTRGSFYCVCDPPWVPDAYNKKCVFPTIIGIDECQDPANCKNGQCVNTQDSYY 1004

Human  1115 CECRPPWVPGPSGRDCQLPESPA------------------------------------------ 1137
            |.|.|||........|..||..|
Zfish  1005 CLCSPPWTLASDRNSCVTPEEQAVMGVSVVHLTDVNECEDPSYCRNGRCVNTPGSFHCICTQPLT 1069

Human  1138 -----------ERAPERRDVCWSQRGEDGMCAGPLAGPALTFDDCCCRQGRGWGAQCRPCPPRG- 1190
                       :|....:|:|:.:..||.||..|.....:|:.:|||..|||||.:||.||.|.
Zfish  1070 FSAALKQCVYDDRTAAHKDICFQEVDEDHMCTMPRNELTVTYSECCCHYGRGWGPECRTCPMRNT 1134

Human  1191 ------AGSHCPT-SQSESN---SFWDTSPLLLGKPPRDEDSSEEDSDECRCVSGRCVPRPGGAV 1245
                  ...|..| |..|.:   :|...:|        :.||||||||||.|.:||||....|.:
Zfish  1135 VLFNRLCEMHLETESDGEGDFLAAFSTYNP--------EGDSSEEDSDECSCANGRCVRSYLGTM 1191

Human  1246 CECPGGFQLDASRARCVDIDECRELNQRGLLCKSERCVNTSGSFRCVCKAGF-ARSRPHGACVPQ 1309
            |||..||.||.||.||.|||||.........||:.||:||.|||||.||.|| |..||| .|:..
Zfish  1192 CECNTGFVLDHSRTRCTDIDECAGRGTGQSPCKNARCINTFGSFRCQCKLGFVAARRPH-VCLRS 1255

Human  1310 R 1310
            |
Zfish  1256 R 1256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LTBP3	XP_011543334.1	EGF_CA	364..399	CDD:214542	21/34 (62%)
		TB	424..459	CDD:279073	22/34 (65%)
		EGF_CA	625..668	CDD:214542	24/43 (56%)
		EGF_CA	669..703	CDD:238011	19/33 (58%)
		EGF_CA	712..745	CDD:214542	18/32 (56%)
		EGF_CA	753..792	CDD:214542	16/38 (42%)
		EGF_CA	794..834	CDD:214542	19/39 (49%)
		EGF_CA	835..874	CDD:214542	21/38 (55%)
		EGF_CA	875..908	CDD:214542	20/32 (63%)
		TB	938..975	CDD:279073	32/36 (89%)
		EGF_CA	1045..>1073	CDD:214542	18/27 (67%)
		EGF_CA	1091..1126	CDD:214542	19/34 (56%)
		TB	1157..1190	CDD:279073	15/32 (47%)
ltbp3	NP_001244070.1	EGF_CA	290..>320	CDD:214542	19/29 (66%)
		TB	348..382	CDD:279073	21/33 (64%)
		EGF_CA	562..594	CDD:214542	18/31 (58%)
		EGF_CA	605..640	CDD:214542	19/35 (54%)
		EGF_CA	645..>675	CDD:214542	14/29 (48%)
		EGF_CA	686..726	CDD:214542	19/39 (49%)
		EGF_CA	727..766	CDD:214542	21/38 (55%)
		EGF_CA	767..809	CDD:214542	23/41 (56%)
		TB	828..865	CDD:279073	32/36 (89%)
		EGF_CA	935..>965	CDD:214542	19/29 (66%)
		EGF_CA	982..1012	CDD:214542	18/29 (62%)
		EGF_CA	1038..>1064	CDD:214542	0/25 (0%)
		TB	<1109..1135	CDD:279073	14/25 (56%)
		EGF_CA	1209..>1243	CDD:214542	18/33 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194327454
Domainoid	1	1.000	100	1.000	Domainoid score	I26089
eggNOG	1	0.900	-	-		E33208_3BHBV
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7405
Inparanoid	1	1.050	1298	1.000	Inparanoid score	I1354
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG42442
OrthoDB	1	1.010	-	-		D10682at7742
OrthoFinder	1	1.000	-	-		FOG0012151
OrthoInspector	1	1.000	-	-		oto46114
orthoMCL	1	0.900	-	-		OOG6_104731
Panther	1	1.100	-	-	LDO	PTHR24034
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8702
SonicParanoid	1	1.000	-	-		X10894
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300