DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9766 and FANK1

DIOPT Version :9

Sequence 1:	NP_001097672.1	Gene:	CG9766 / 40539	FlyBaseID:	FBgn0037229	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	XP_011538650.1	Gene:	FANK1 / 92565	HGNCID:	23527	Length:	381	Species:	Homo sapiens

Alignment Length:	364	Identity:	90/364 - (24%)
Similarity:	141/364 - (38%)	Gaps:	92/364 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PDFVSRISNPTVNSVQLHWSLLKNASVYCIDKFHKRLG----WLQLDWTSSSP------------ 78
            |..|.::   |.:|::|:|.|.|.|         ||.|    |.:.......|
Human    24 PPVVGKV---THHSIELYWDLEKKA---------KRQGPQEQWFRFSIEEEDPKMHTYGIIYTGY 76

  Fly    79 ---ITVTNLEENFGYRLRIKALTVSKDGHC-YVPL--------AISPEIVAC------------- 118
               ..|..||....||.|:|  ..|..|.| |.||        ::|..:|..
Human    77 ATKHVVEGLEPRTLYRFRLK--VTSPSGECEYSPLVSVSTTRPSLSKSLVKIRMVTSVLHGPPTE 139

  Fly   119 -TAAALPSTHCLSRAIRKGQQFLVKRMLRRRPSLMEYPASNGFLPLANAIIQGEMCIIDLLLSAG 182
             |...:.|.| |.||:....:.|:.|:|:.....::.|...||..|..|..:|...::.:|:|.|
Human   140 NTGEPISSEH-LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNG 203

  Fly   183 CSVHIGDPGSGRTPLHLAFYYGHLPSARILLNKKARLEATDSNGMTPAHCAVDANQLEIVKFALE 247
            ..|::.: |||:..|.||.|.|||...:.|....|..:|.|..|.|..|.|.|.....::::.::
Human   204 TDVNLKN-GSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIK 267

  Fly   248 AGANAEARDV-CGWTLLMR---------------------------------AVVMNASMELIKV 278
            .|...:..|. .|||.|||                                 ..|:|...||:::
Human   268 DGCEVDVVDTGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQL 332

  Fly   279 LVTHGADLAALDGVGKTCTDLAKLYHRQEAKDYFDEVQK 317
            |:..|||.:..:..||...::|:::.||......:|.:|
Human   333 LLDKGADASVKNEFGKGVLEMARVFDRQSVVSLLEERKK 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9766	NP_001097672.1	FN3	35..98	CDD:214495	19/81 (23%)
		ANK	128..244	CDD:238125	35/115 (30%)
		ANK repeat	128..156	CDD:293786	6/27 (22%)
		Ank_2	129..223	CDD:289560	29/93 (31%)
		ANK repeat	158..189	CDD:293786	9/30 (30%)
		ANK repeat	192..223	CDD:293786	12/30 (40%)
		ANK	193..311	CDD:238125	38/151 (25%)
		Ank_2	197..290	CDD:289560	32/126 (25%)
		ANK repeat	225..256	CDD:293786	6/30 (20%)
		ANK repeat	258..290	CDD:293786	14/64 (22%)
FANK1	XP_011538650.1	FN3	19..103	CDD:214495	22/92 (24%)
		Ank_2	150..243	CDD:315466	29/93 (31%)
		ANK repeat	150..177	CDD:293786	6/26 (23%)
		ANK repeat	179..210	CDD:293786	9/30 (30%)
		ANK	207..334	CDD:238125	31/127 (24%)
		ANK repeat	212..243	CDD:293786	12/30 (40%)
		ANK repeat	245..311	CDD:293786	13/65 (20%)
		ANK	308..>366	CDD:238125	13/57 (23%)
		ANK repeat	313..344	CDD:293786	8/30 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BKQB
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50214
OrthoDB	1	1.010	-	-		D1514637at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830