DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9766 and Fank1

DIOPT Version :9

Sequence 1:	NP_001097672.1	Gene:	CG9766 / 40539	FlyBaseID:	FBgn0037229	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_080126.1	Gene:	Fank1 / 66930	MGIID:	1914180	Length:	344	Species:	Mus musculus

Alignment Length:	347	Identity:	86/347 - (24%)
Similarity:	139/347 - (40%)	Gaps:	72/347 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PDFVSRISNPTVNSVQLHWSLLKNASVYCIDKFHKRLG----WLQLDWTSSSP------------ 78
            |..|.::   |.:|::|:|.|         ::..||.|    ||:.......|
Mouse    14 PPVVGKV---THHSIELYWDL---------EQKEKRQGPQEQWLRFSIEEEDPKMHSYGVIYTGY 66

  Fly    79 ---ITVTNLEENFGYRLRIKALTVSKDGHCYVPLAISPEIVACTAAALPSTHCLSRAIRKGQQFL 140
               ..|..||....|:.|:|..:.|.: :.|.|:.    .||.|...:.|.| ..||:....:.|
Mouse    67 ATRHVVEGLEPRTLYKFRLKVTSPSGE-YEYSPVV----SVATTREPISSEH-FHRAVSVNDEDL 125

  Fly   141 VKRMLRRRPSLMEYPASNGFLPLANAIIQGEMCIIDLLLSAGCSVHIGDPGSGRTPLHLAFYYGH 205
            :.|:|.....:::.|...||..|..|..:|...::.:|:|.|..|::.: |||:..|.||.|.||
Mouse   126 LLRILEGGHVMIDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKN-GSGKDSLMLACYAGH 189

  Fly   206 LPSARILLNKKARLEATDSNGMTPAHCAVDANQLEIVKFALEAGANAEARDV-CGWTLLMR---- 265
            |...:.|....|..||.|..|.|..|.|.|.....::.:.::.|...:..|. .|||.|||
Mouse   190 LDVVKYLRRHGASWEARDLGGCTALHWAADGGHCSVIDWMIKDGCEVDVVDTGSGWTPLMRVSAV 254

  Fly   266 -----------------------------AVVMNASMELIKVLVTHGADLAALDGVGKTCTDLAK 301
                                         ..|:|...:|:::|:..|||....:..||...::|:
Mouse   255 TGSQKVASLLIEAGADVNIKDKDGKTPLMVAVLNNHEQLVQLLLDKGADATVKNEFGKGVLEMAR 319

  Fly   302 LYHRQEAKDYFDEVQKFRLEKS 323
            ::.||......:|.:|....||
Mouse   320 VFDRQNVLSLLEEKKKKMPRKS 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9766	NP_001097672.1	FN3	35..98	CDD:214495	17/81 (21%)
		ANK	128..244	CDD:238125	35/115 (30%)
		ANK repeat	128..156	CDD:293786	5/27 (19%)
		Ank_2	129..223	CDD:289560	29/93 (31%)
		ANK repeat	158..189	CDD:293786	9/30 (30%)
		ANK repeat	192..223	CDD:293786	13/30 (43%)
		ANK	193..311	CDD:238125	38/151 (25%)
		Ank_2	197..290	CDD:289560	32/126 (25%)
		ANK repeat	225..256	CDD:293786	6/30 (20%)
		ANK repeat	258..290	CDD:293786	13/64 (20%)
Fank1	NP_080126.1	FN3	10..104	CDD:238020	23/106 (22%)
		ANK 1	109..139		7/30 (23%)
		Ank_4	113..164	CDD:290365	12/51 (24%)
		ANK repeat	114..141	CDD:293786	5/26 (19%)
		ANK repeat	143..174	CDD:293786	9/30 (30%)
		ANK 2	143..172		9/28 (32%)
		Ank	144..174	CDD:278452	9/29 (31%)
		Ank_2	148..240	CDD:289560	28/92 (30%)
		ANK	171..298	CDD:238125	31/127 (24%)
		ANK repeat	176..207	CDD:293786	13/30 (43%)
		ANK 3	176..205		11/28 (39%)
		ANK repeat	209..275	CDD:293786	13/65 (20%)
		ANK 4	209..238		6/28 (21%)
		Ank_2	214..308	CDD:289560	18/93 (19%)
		ANK 5	243..273		6/29 (21%)
		ANK	272..>330	CDD:238125	12/57 (21%)
		ANK repeat	277..308	CDD:293786	7/30 (23%)
		ANK 6	277..306		7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BKQB
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50214
OrthoDB	1	1.010	-	-		D1514637at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830