DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG14644 and NPHS2

DIOPT Version :9

Sequence 1:NP_649445.3 Gene:CG14644 / 40536 FlyBaseID:FBgn0250821 Length:293 Species:Drosophila melanogaster
Sequence 2:NP_055440.1 Gene:NPHS2 / 7827 HGNCID:13394 Length:383 Species:Homo sapiens


Alignment Length:269 Identity:93/269 - (34%)
Similarity:161/269 - (59%) Gaps:3/269 - (1%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 ESLLPQRNVKTSENVPPTCAEKTLFVLSMILIVLCLPWSLFCCLRVMSEYERAVILRLGRLRPKP 87
            ||..|:...|:|   .....|..|.::|::.|::..|:|::.|::|:.||||.:|.|||.|.|..
Human    85 ESERPEEGTKSS---GLGACEWLLVLISLLFIIMTFPFSIWFCVKVVQEYERVIIFRLGHLLPGR 146

  Fly    88 PRGPGVIFLVPCIDDLAVVDIRTRSFDLHRQEILTRDMVTISIDGVVYYSIKSPFDAMLQVYDPE 152
            .:|||:.|.:||:|....||:|.::.::...||:|:||..:.||.:.||.:::....:..:....
Human   147 AKGPGLFFFLPCLDTYHKVDLRLQTLEIPFHEIVTKDMFIMEIDAICYYRMENASLLLSSLAHVS 211

  Fly   153 EATEKLAMTTLRNVAGTHKLMDLLSSKEYLSNQIEGILYNSTEPWGIRVERVEIKEIFMPDQLKR 217
            :|.:.|..||::.:.....|.::|..::.::...:..|.:.|..|||:|||:|||::.:|..|:.
Human   212 KAVQFLVQTTMKRLLAHRSLTEILLERKSIAQDAKVALDSVTCIWGIKVERIEIKDVRLPAGLQH 276

  Fly   218 ALAVEQEAMREAKAKVAAAQGERDAVTALKEAADIMETNPIALQLRYLQTLNSICNDDTRSYVFP 282
            :||||.||.|:||.::.||:.|:.|..:|:.||:|:...|.|:|||||.||.|:..:...:.|.|
Human   277 SLAVEAEAQRQAKVRMIAAEAEKAASESLRMAAEILSGTPAAVQLRYLHTLQSLSTEKPSTVVLP 341

  Fly   283 FPVDIVRNL 291
            .|.|::..|
Human   342 LPFDLLNCL 350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG14644NP_649445.3 PHB 64..223 CDD:214581 53/158 (34%)
SPFH_like 89..292 CDD:302763 70/203 (34%)
NPHS2NP_055440.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..76
SPFH_podocin 122..344 CDD:259809 79/221 (36%)
PHB 123..287 CDD:214581 56/163 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 355..383
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0330
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062075at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
43.780

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