DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14644 and Nphs2

DIOPT Version :9

Sequence 1:	NP_649445.3	Gene:	CG14644 / 40536	FlyBaseID:	FBgn0250821	Length:	293	Species:	Drosophila melanogaster
Sequence 2:	NP_570841.3	Gene:	Nphs2 / 170672	RGDID:	620461	Length:	383	Species:	Rattus norvegicus

Alignment Length:	270	Identity:	98/270 - (36%)
Similarity:	163/270 - (60%)	Gaps:	4/270 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 ESLLPQRNVKTSENVPPTCAEKTLFVLSMILIVLCLPWSLFCCLRVMSEYERAVILRLGRLRPKP 87
            ||..|:..:|.|   .....|..|.:.|:|.|::..|:|::.|::|:.||||.:|.|||.|.|..
  Rat    85 ESERPEEGIKPS---GLGACEWLLVLSSLIFIIVTFPFSIWFCIKVVQEYERVIIFRLGHLLPGR 146

  Fly    88 PRGPGVIFLVPCIDDLAVVDIRTRSFDLHRQEILTRDMVTISIDGVVYYSIKSPFDAMLQVYDPE 152
            .:|||:.|.:||:|....||:|.::.::...|::|:||..:.||.|.||.:::....:..:....
  Rat   147 AKGPGLFFFLPCLDTYHKVDLRLQTLEIPFHEVVTKDMFIMEIDAVCYYRMENASLLLSSLAHVS 211

  Fly   153 EATEKLAMTTLRNVAGTHKLMDLLSSKEYLSNQIEGILYNSTEPWGIRVERVEIKEIFMPDQLKR 217
            :|.:.|..||::.:.....|.::|..::.::..::..|.:.|..|||:|||.|||::.:|..|:.
  Rat   212 KAIQFLVQTTMKRLLAHRSLTEILLERKSIAQDVKVALDSVTCVWGIKVERTEIKDVRLPAGLQH 276

  Fly   218 ALAVEQEAMREAKAKVAAAQGERDAVTALKEAADIMETNPIALQLRYLQTLNSICNDDTRSYVFP 282
            :||||.||.|:||.:|.||:||:.|..:|:.||:|:...|.|:|||||.||.|:..|...:.|.|
  Rat   277 SLAVEAEAQRQAKVRVIAAEGEKAASESLRMAAEILSGTPAAVQLRYLHTLQSLSTDKPSTVVLP 341

  Fly   283 FPVDIVRNLM 292
            .|.|:: ||:
  Rat   342 LPFDML-NLL 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14644	NP_649445.3	PHB	64..223	CDD:214581	53/158 (34%)
CG14644	NP_649445.3	SPFH_like	89..292	CDD:302763	73/202 (36%)
Nphs2	NP_570841.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73
		SPFH_podocin	122..344	CDD:259809	82/221 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	355..383
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062075at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.780