DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	326	Identity:	92/326 - (28%)
Similarity:	136/326 - (41%)	Gaps:	91/326 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 PPPGGFKKKENKQRRLCEQ------KYSEYVERIFPNDTAVAADANDADFDGRVLARPGEYPHMA 159
            |..|||.::..:.|..|..      :.||...|  |..:.:..        |:.:| ||.:|..|
Human   180 PRLGGFLEEAWQPRNNCTSGQVVSLRCSECGAR--PLASRIVG--------GQSVA-PGRWPWQA 233

  Fly   160 --AVGFESDRGQVDYKCGGSLISERFVLTAAHCTSIYEAP--PKW-VRIGDLDLASEKRSVEAQL 219
              |:||.       :.||||:::.|:|:|||||...:...  ..| |..|   |.|.......|.
Human   234 SVALGFR-------HTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAG---LVSHSAVRPHQG 288

  Fly   220 LRIEQVFAHPNYKKKMYYDDIALLKLEKEVELTEYVRPV-------------RLWVFPELPTTIA 271
            ..:|::..||.|..:.:..|:|||:|:..:..::.|..|             |.||
Human   289 ALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWV--------- 344

  Fly   272 FAMGYGAT----SFAKPMTNRLTNLNLTVVP-------NAECNAELPPLAETPSGVLESQICAQD 325
              .|:|.|    :::..|      |..||||       |:.|         ..||.|..::....
Human   345 --SGWGHTHPSHTYSSDM------LQDTVVPLFSTQLCNSSC---------VYSGALTPRMLCAG 392

  Fly   326 YILNR-DTCQGDSGGPLQLNLPGRRRGHRIHYHLIGITSYGVFC-RSSYPSVYTRVSSFLDWIEL 388
            |:..| |.|||||||||.  .|....     :.|:|:.|:|..| ..::|.||.:|:.|||||..
Human   393 YLDGRADACQGDSGGPLV--CPDGDT-----WRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIHD 450

  Fly   389 T 389
            |
Human   451 T 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	80/271 (30%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	79/270 (29%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133	9/34 (26%)
		Tryp_SPc	217..448	CDD:214473	79/282 (28%)
		Tryp_SPc	218..451	CDD:238113	81/284 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910