DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and ST14

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_068813.1	Gene:	ST14 / 6768	HGNCID:	11344	Length:	855	Species:	Homo sapiens

Alignment Length:	285	Identity:	84/285 - (29%)
Similarity:	123/285 - (43%)	Gaps:	55/285 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 DTAVAADANDADFDGRVLAR-----------PGEYP---HMAAVGFESDRGQVDYKCGGSLISER 182
            |.:..:|..|.|...|...|           .||:|   .:.|:|    :|.:   ||.||||..
Human   592 DCSDGSDEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALG----QGHI---CGASLISPN 649

  Fly   183 FVLTAAHC-----TSIYEAPPKWVRIGDLDLASEKRSVEAQLLRIEQVFAHPNYKKKMYYDDIAL 242
            ::::||||     ...|..|.:|.....|...|::.:...|..|::::.:||.:....:..||||
Human   650 WLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIAL 714

  Fly   243 LKLEKEVELTEYVRPVRL----WVFPELPTTIAFAMGYGATSFAKPMTNRLTNLNLTVVPNAECN 303
            |:|||..|.:..|||:.|    .|||  .....:..|:|.|.:.......|....:.|:....|.
Human   715 LELEKPAEYSSMVRPICLPDASHVFP--AGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCE 777

  Fly   304 AELPPLAETPS----GVLESQICAQDYILNRDTCQGDSGGPL-QLNLPGRRRGHRIHYHLIGITS 363
             .|.|...||.    |.|...:         |:||||||||| .:...||       ....|:.|
Human   778 -NLLPQQITPRMMCVGFLSGGV---------DSCQGDSGGPLSSVEADGR-------IFQAGVVS 825

  Fly   364 YGVFC-RSSYPSVYTRVSSFLDWIE 387
            :|..| :.:.|.||||:..|.|||:
Human   826 WGDGCAQRNKPGVYTRLPLFRDWIK 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	79/269 (29%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	78/268 (29%)
ST14	NP_068813.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SEA	88..>171	CDD:307516
		CUB	227..332	CDD:238001
		CUB	340..444	CDD:238001
		LDLa	454..486	CDD:238060
		LDLa	488..523	CDD:238060
		LDLa	525..559	CDD:238060
		LDLa	567..602	CDD:238060	2/9 (22%)
		Tryp_SPc	615..852	CDD:238113	78/262 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910