DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and PRSS56

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001356777.1	Gene:	PRSS56 / 646960	HGNCID:	39433	Length:	604	Species:	Homo sapiens

Alignment Length:	321	Identity:	92/321 - (28%)
Similarity:	137/321 - (42%)	Gaps:	67/321 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 GPTQPKPKPRQYPPPPMPGQPFPPPPGGFKKKENKQRRLCEQKYSEYVERIFPNDTAVAADANDA 142
            |..:|:|:.....||       .|.|.|       :||                    .:.||..
Human    69 GSGRPRPQALLQDPP-------EPGPCG-------ERR--------------------PSTANVT 99

  Fly   143 DFDGRVL----ARPGEYPHMAAVGFESDRGQVDYKCGGSLISERFVLTAAHCTSIYEAPPK--WV 201
            ...||::    |.||.:|.:..:..   .||.  .|||.|::..:|||||||  ...||.:  |.
Human   100 RAHGRIVGGSAAPPGAWPWLVRLQL---GGQP--LCGGVLVAASWVLTAAHC--FVGAPNELLWT 157

  Fly   202 RIGDLDLASEKRSVEAQLLRIEQVFAHPNYKKKMYYDDIALLKLEKEVELTEYVRPVRLWVFPEL 266
                :.||...|..:|:.:.:.::..||.:..:.:::|:||::|...|......|||.|...|:.
Human   158 ----VTLAEGSRGEQAEEVPVNRILPHPKFDPRTFHNDLALVQLWTPVSPGGSARPVCLPQEPQE 218

  Fly   267 P---TTIAFAMGYGATSFAKPMTNRLTNLNLTVVPNAECNAELPPLAETPSGVLESQICAQDYIL 328
            |   |..|.| |:||.....|....:....:.::....|...|.|      |:..|.:....|:.
Human   219 PPAGTACAIA-GWGALFEDGPEAEAVREARVPLLSTDTCRRALGP------GLRPSTMLCAGYLA 276

  Fly   329 NR-DTCQGDSGGPLQLNLPGRRRGHRIHYHLIGITSYGVFC-RSSYPSVYTRVSSFLDWIE 387
            .. |:|||||||||..:.||.|.    ...|.|:||:|..| ....|.|||||:.|.||::
Human   277 GGVDSCQGDSGGPLTCSEPGPRP----REVLFGVTSWGDGCGEPGKPGVYTRVAVFKDWLQ 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	80/251 (32%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	79/250 (32%)
PRSS56	NP_001356777.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..96		10/60 (17%)
		Tryp_SPc	105..335	CDD:238113	78/251 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..475
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910