DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and Masp2

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_742040.1	Gene:	Masp2 / 64459	RGDID:	620214	Length:	685	Species:	Rattus norvegicus

Alignment Length:	452	Identity:	107/452 - (23%)
Similarity:	174/452 - (38%)	Gaps:	141/452 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 WCLSNTHTQR------LPPEGRMRPLQ-----DDS-----------IRSPV-------------- 44
            |.:..|.|.:      .||.|.:.|:|     .||           ::..|
  Rat   289 WKIHYTSTAQPCPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFELLQGSVPLKSFTAVCQKDGS 353

  Fly    45 -DRDIVFPE---LDAGPGKPEEKMWFHITDFQFDRVEGPTQPKPKP-RQYPPPPMPGQPFPPPPG 104
             ||.|  ||   :|.||  |::....|:     |.:.||.....|. .||.
  Rat   354 WDRPI--PECSIIDCGP--PDDLPNGHV-----DYITGPEVTTYKAVIQYS-------------- 395

  Fly   105 GFKKKENKQRRLCEQKY------SEYV------------ERIFPNDTAVAADANDADFDGRVL-- 149
                        ||:.:      .:||            |:..|....|...:.... .||::
  Rat   396 ------------CEETFYTMSSNGKYVCEADGFWTSSKGEKSLPVCKPVCGLSTHTS-GGRIIGG 447

  Fly   150 --ARPGEYPHMAAVGFESDRGQVDYKCGGSLISERFVLTAAHCTSIY---EAPPKW-VRIGDLDL 208
              |:||::|....:..|:       ...|:||.:.:||||||  ::|   ||.... :|:|.|
  Rat   448 QPAKPGDFPWQVLLLGET-------TAAGALIHDDWVLTAAH--AVYGKTEAMSSLDIRMGIL-- 501

  Fly   209 ASEKRSVEAQLLRIEQVFAHPNYKKKMYYD-DIALLKLEKEVELTEYVRPVRL-------WVFPE 265
              ::.|........|.||.|..|.....:| ||||:||:.:|.:...:.|:.|       .:..:
  Rat   502 --KRLSPHYTQAWPEAVFIHEGYTHGAGFDNDIALIKLKNKVTINRNIMPICLPRKEAASLMKTD 564

  Fly   266 LPTTIAFAMGYGAT--SFAKPMTNRLTNLNLTVVPNAECNAELPPLAETPSGVLESQICAQDYIL 328
            ...|:|   |:|.|  .|   :...|..:::.:|.:.:|...........:.|..:.:||.....
  Rat   565 FVGTVA---GWGLTQKGF---LARNLMFVDIPIVDHQKCATAYTKQPYPGAKVTVNMLCAGLDAG 623

  Fly   329 NRDTCQGDSGGPLQ-LNLPGRRRGHRIHYHLIGITSYG-VFCRSSYP-SVYTRVSSFLDWIE 387
            .:|:|:|||||.|. |:...:|      :.:.||.|:| :.|..|.. .|||:|::::.|||
  Rat   624 GKDSCRGDSGGALVFLDNETQR------WFVGGIVSWGSINCGGSEQYGVYTKVTNYIPWIE 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	71/261 (27%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	70/260 (27%)
Masp2	NP_742040.1	CUB	19..136	CDD:238001
		FXa_inhibition	152..180	CDD:291342
		CUB	184..295	CDD:238001	1/5 (20%)
		Sushi	300..361	CDD:278512	12/62 (19%)
		Sushi	366..429	CDD:278512	16/95 (17%)
		Tryp_SPc	443..678	CDD:214473	69/259 (27%)
		Tryp_SPc	444..681	CDD:238113	71/261 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910