DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	243	Identity:	85/243 - (34%)
Similarity:	121/243 - (49%)	Gaps:	41/243 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 VGFESDRGQVDYKCGGSLISERFVLTAAHC----TSIYEAPPKW-VRIGDLDLASEKRSVEAQLL 220
            |..:.|:..|   ||||::...:|||||||    |.::    .| ||.|...|.|......|:::
Human   220 VSIQYDKQHV---CGGSILDPHWVLTAAHCFRKHTDVF----NWKVRAGSDKLGSFPSLAVAKII 277

  Fly   221 RIEQVFAHPNYKKKMYYDDIALLKLEKEVELTEYVRPVRLWVFPE--LPTTIAFAMGYGATSFAK 283
            .||   .:|.|.|.   :||||:||:..:..:..|||:.|..|.|  .|.|..:.:|:|   |.|
Human   278 IIE---FNPMYPKD---NDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPLWIIGWG---FTK 333

  Fly   284 ----PMTNRLTNLNLTVVPNAECNAELPPLAETPSGVLESQICAQDYILNRDTCQGDSGGPLQLN 344
                .|::.|...::.|:.:..|||:.....|    |.|..:||.......|||||||||||...
Human   334 QNGGKMSDILLQASVQVIDSTRCNADDAYQGE----VTEKMMCAGIPEGGVDTCQGDSGGPLMYQ 394

  Fly   345 LPGRRRGHRIHYHLIGITSYGVFCRS-SYPSVYTRVSSFLDWIELTVW 391
            ..        .:|::||.|:|..|.. |.|.|||:||::|:|| ..||
Human   395 SD--------QWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI-YNVW 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	82/237 (35%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	81/236 (34%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335
		Tryp_SPc	204..429	CDD:214473	81/236 (34%)
		Tryp_SPc	205..432	CDD:238113	83/240 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910