DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and TMPRSS15

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	XP_011527956.1	Gene:	TMPRSS15 / 5651	HGNCID:	9490	Length:	1064	Species:	Homo sapiens

Alignment Length:	246	Identity:	75/246 - (30%)
Similarity:	122/246 - (49%)	Gaps:	29/246 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 ARPGEYPHMAAVGFESDRGQVDYKCGGSLISERFVLTAAHCTSIYE---APPKWVRIGDLDLASE 211
            |:.|.:|.:..:.:   .|::  .||.||:|..::::||||  :|.   .|.||..|..|.:.|.
Human   836 AKEGAWPWVVGLYY---GGRL--LCGASLVSSDWLVSAAHC--VYGRNLEPSKWTAILGLHMKSN 893

  Fly   212 KRSVEAQLLRIEQVFAHPNYKKKMYYDDIALLKLEKEVELTEYVRPVRL----WVFPELPTTIAF 272
            ..|.:.....|:::..:|:|.::...:|||::.||.:|..|:|::|:.|    .|||  |.....
Human   894 LTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFP--PGRNCS 956

  Fly   273 AMGYGATSFAKPMTNRLTNLNLTVVPNAECNAELPPLAETPSGVLESQICAQDYILNRDTCQGDS 337
            ..|:|...:.....|.|...::.::.|..|..::|..     .:.|:.|||.......|:|||||
Human   957 IAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEY-----NITENMICAGYEEGGIDSCQGDS 1016

  Fly   338 GGPLQLNLPGRRRGHRIHYHLIGITSYGVFCR-SSYPSVYTRVSSFLDWIE 387
            ||||......|       :.|.|:||:|..|. .:.|.||.|||.|.:||:
Human  1017 GGPLMCQENNR-------WFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQ 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	74/244 (30%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	73/243 (30%)
TMPRSS15	XP_011527956.1	SEA	53..195	CDD:214554
		LDLa	229..263	CDD:238060
		CUB	270..376	CDD:278839
		MAM	387..547	CDD:214533
		MAM	392..547	CDD:99706
		CUB	569..676	CDD:278839
		LDLa	688..722	CDD:238060
		SR	723..816	CDD:214555
		Tryp_SPc	829..1059	CDD:214473	73/243 (30%)
		Tryp_SPc	830..1061	CDD:238113	75/246 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910