DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and MASP1

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	XP_011511291.1	Gene:	MASP1 / 5648	HGNCID:	6901	Length:	735	Species:	Homo sapiens

Alignment Length:	355	Identity:	96/355 - (27%)
Similarity:	149/355 - (41%)	Gaps:	91/355 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 FKKKENKQRRLCEQKYS--EYVERIFPNDTAVAADANDADFDGRVLAR----------------- 151
            |..:.|......|.|||  |...::..|:|.:...:....:..:||.|
Human   387 FSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVWMNKVLGRSLPTCLPECGQPSRSLP 451

  Fly   152 -------------PGEYPHMAAVGFESDRGQV--DYKCG-GSLISERFVLTAAHC-------TSI 193
                         ||.:|..|.:..| |..:|  |...| |:|:|..::|||||.       |::
Human   452 SLVKRIIGGRNAEPGLFPWQALIVVE-DTSRVPNDKWFGSGALLSASWILTAAHVLRSQRRDTTV 515

  Fly   194 YEAPPKWVRI--GDLDLASEKRSVEAQLLRIEQVFAHPNYKKKMYYDDIALLKLEKEVELTEYVR 256
            .....:.|.:  |..|:..:..:|.:...|   |..||::..:.|..||||::|::.|.|..:|.
Human   516 IPVSKEHVTVYLGLHDVRDKSGAVNSSAAR---VVLHPDFNIQNYNHDIALVQLQEPVPLGPHVM 577

  Fly   257 PVRLWVFPEL------PTTIAFAMGYG-----------ATSFAKPMTNRLTNLNLTVVPNAECNA 304
            ||.|   |.|      |..:....|:|           .:|..:.:::.|..:.|.|||:|||..
Human   578 PVCL---PRLEPEGPAPHMLGLVAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKT 639

  Fly   305 ELPPLAETPSG---VLESQICAQDYILNRDTCQGDSGGPLQL--NLPGRRRGHRIHYHLIGITSY 364
            ..    |:.||   |.|:..||..|...:|||.|||||...:  :|..|       :.:.|:.|:
Human   640 SY----ESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQR-------WVVQGLVSW 693

  Fly   365 G--VFCRSSYP-SVYTRVSSFLDWIELTVW 391
            |  ..|.|... .|||:||:::||    ||
Human   694 GGPEECGSKQVYGVYTKVSNYVDW----VW 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	85/307 (28%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	84/306 (27%)
MASP1	XP_011511291.1	CUB	35..144	CDD:238001
		FXa_inhibition	160..188	CDD:291342
		CUB	192..301	CDD:278839
		Sushi	308..369	CDD:278512
		CCP	374..439	CDD:153056	12/51 (24%)
		Tryp_SPc	456..718	CDD:214473	82/283 (29%)
		Tryp_SPc	457..718	CDD:238113	82/282 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910