DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and TMPRSS11F

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_997290.2	Gene:	TMPRSS11F / 389208	HGNCID:	29994	Length:	438	Species:	Homo sapiens

Alignment Length:	264	Identity:	80/264 - (30%)
Similarity:	122/264 - (46%)	Gaps:	43/264 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 AADANDADFDGRVLARPGEYPHMAAVGFESDRGQVDYKCGGSLISERFVLTAAHCTSIYEAPPKW 200
            |:.:......||..|..||:|..|::.....    .::||.||||..::||||||....:.|.:|
Human   199 ASSSTQRIVQGRETAMEGEWPWQASLQLIGS----GHQCGASLISNTWLLTAAHCFWKNKDPTQW 259

  Fly   201 VRI--GDLDLASEKRSVEAQLLRIEQVFAHPNYKKKMYYDDIALLKLEKEVELTEYVRPVRLWVF 263
            :..  ..:...:.||:|       .::..|.||.::...:||||::|...||.:..|:.|.|
Human   260 IATFGATITPPAVKRNV-------RKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCL--- 314

  Fly   264 PEL-----PTTIAFAMGYGATSFAKPMTNRLTNLNLTVVPNAECN-AELPPLAETP----SGVLE 318
            |:.     |.|..|..|:|:.....|:.|.|....:..:....|| .::.....||    :|.:|
Human   315 PDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFME 379

  Fly   319 SQICAQDYILNRDTCQGDSGGPLQLNLPGRRRGHRIHYHLIGITSYGVFCR-SSYPSVYTRVSSF 382
            .:|         |.|:|||||||..:      .|.|.| ::||.|:|..|. ...|.|||||:.:
Human   380 GKI---------DACKGDSGGPLVYD------NHDIWY-IVGIVSWGQSCALPKKPGVYTRVTKY 428

  Fly   383 LDWI 386
            .|||
Human   429 RDWI 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	79/254 (31%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	77/252 (31%)
TMPRSS11F	NP_997290.2	SEA	59..154	CDD:279699
		Tryp_SPc	205..432	CDD:214473	77/256 (30%)
		Tryp_SPc	206..435	CDD:238113	79/257 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910