DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14642 and TMPRSS7

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001382436.1	Gene:	TMPRSS7 / 344805	HGNCID:	30846	Length:	843	Species:	Homo sapiens

Alignment Length:	327	Identity:	85/327 - (25%)
Similarity:	129/327 - (39%)	Gaps:	76/327 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 GFKKKENKQRRLCEQKYSEYV---ERIFP--NDTAV---------AADAND-ADFDGRVLARPGE 154
            ||:..||.:.   ||..::.:   .|.|.  ||...         ..|..| :|.:|...:|...
Human   540 GFRDCENGRD---EQNCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCTCSRSSS 601

  Fly   155 YPHMAAVGFESDRG----QVDYK------CGGSLISERFVLTAAHC--TSIYEAPPKWVRIGDLD 207
            ..|....|.::..|    ||...      ||.|:||..::|:||||  .:....|..|.....:.
Human   602 ALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLGMY 666

  Fly   208 LASEKRSVEAQLLRIEQVFAHPNYKKKMYYDDIALLKLE---KEVELTEYVRPV----------- 258
            :....:.|..    :.::..|..|..:.:..|||||:|.   .|. |.:.::|:
Human   667 VQGNAKFVSP----VRRIVVHEYYNSQTFDYDIALLQLSIAWPET-LKQLIQPICIPPTGQRVRS 726

  Fly   259 --RLWVFPELPTTIAFAMGYGATSFAKPMTNRLTNLNLTVVPNAECNAELPPLAETPSGVLESQ- 320
              :.||           .|:|       ..:...|....|:..||.......|..:..|::.|:
Human   727 GEKCWV-----------TGWG-------RRHEADNKGSLVLQQAEVELIDQTLCVSTYGIITSRM 773

  Fly   321 ICAQDYILNRDTCQGDSGGPLQLNLPGRRRGHRIHYHLIGITSYGVFC-RSSYPSVYTRVSSFLD 384
            :||......||.|:|||||||..     ||.....:.|.||.|:|... |.::|.||||||:|:.
Human   774 LCAGIMSGKRDACKGDSGGPLSC-----RRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVP 833

  Fly   385 WI 386
            ||
Human   834 WI 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	72/271 (27%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	70/269 (26%)
TMPRSS7	NP_001382436.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..67
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000