DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and f2

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	XP_005169022.1	Gene:	f2 / 325881	ZFINID:	ZDB-GENE-030131-4606	Length:	635	Species:	Danio rerio

Alignment Length:	488	Identity:	111/488 - (22%)
Similarity:	174/488 - (35%)	Gaps:	156/488 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GLWCLSNTHTQRLPPEGRMRPLQDDSIRSPVDRDIVFPELDAGPGKPEEKMWFHI---------- 68
            |.||.:...|.|           .::...|...:.|.|...|...|||::   |:
Zfish   184 GPWCFTRDPTVR-----------RETCNVPKCGEAVVPPPKAPTAKPEQR---HVISKCLPGNGE 234

  Fly    69 -------------TDFQFDRVEGPTQPKPK---PR--------QYPPPPMPG------------- 96
                         |..|:...|.....|.|   |:        :.|...|.|
Zfish   235 TYTGELFVTLGLHTCLQWSSAEVQALIKKKELLPQVQLVKNHCRNPDGDMEGPWCYIKAASGNIT 299

  Fly    97 -------------QPFPPPPGGFKKKENKQRRLCEQKYSEYVERIFPN-----------DTAVAA 137
                         ..|....||      ::|...:|:.:.:..|.|.|           :....|
Zfish   300 IDYCDLELCDAPLDKFVEEGGG------RERTTLDQRKAFFNPRSFGNGELDCGERPLFEKINKA 358

  Fly   138 DANDADF-----DGRVLARPGEYPHMAAVGFE---SDRGQVDYKCGGSLISERFVLTAAHCTSIY 194
            |.|:.:.     ..|::.  |:...:|:..::   ..|...:..||.||||:.::||||||. :|
Zfish   359 DKNEKELLMSYTGSRIVG--GDEAEVASAPWQVMLYKRSPQELLCGASLISDEWILTAAHCI-LY 420

  Fly   195 EAPPKW----------VRIGDLDLASEKRSVEAQLLRIEQVFAHPNYK-KKMYYDDIALLKLEKE 248
               |.|          ||:|.......:|.:| :::.|:::..||.|. |:....|||||.::|.
Zfish   421 ---PPWNKNFTINDIIVRLGKHSRTKYERGIE-KIVAIDEIIVHPKYNWKENLNRDIALLHMKKP 481

  Fly   249 VELTEYVRPVRLWVFPELPT-----TIAFAMGY-----GATSFAKPMTNRLTNL-------NLTV 296
            |..|..:.||.      |||     .:.|| ||     |..:..:..|:..|||       :|.:
Zfish   482 VVFTSEIHPVC------LPTKSIAKNLMFA-GYKGRVTGWGNLRESWTSNPTNLPTVLQQIHLPI 539

  Fly   297 VPNAECNAELPPLAETPSGVLESQICA---QDYILNRDTCQGDSGGPLQLNLPGRRRGHRIHYHL 358
            |..:.|.      ..|...:.::..||   .|.....|.|:||||||..:..|...|     ::.
Zfish   540 VDQSICR------NSTSVIITDNMFCAGYQPDDSKRGDACEGDSGGPFVMKSPSDNR-----WYQ 593

  Fly   359 IGITSYGVFC-RSSYPSVYTRVSSFLDWIELTV 390
            |||.|:|..| |......||.:.....|::..:
Zfish   594 IGIVSWGEGCDRDGKYGFYTHLFRMRRWMKKVI 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	78/275 (28%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	77/274 (28%)
f2	XP_005169022.1	GLA	39..100	CDD:214503
		KR	126..206	CDD:214527	6/32 (19%)
		KR	228..309	CDD:214527	9/80 (11%)
		Thrombin_light	326..373	CDD:286482	7/46 (15%)
		Tryp_SPc	373..621	CDD:214473	77/272 (28%)
		Tryp_SPc	374..625	CDD:238113	77/275 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910